Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1K0W

CRYSTAL STRUCTURE OF L-RIBULOSE-5-PHOSPHATE 4-EPIMERASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005829	cellular_component	cytosol
A	0005996	biological_process	monosaccharide metabolic process
A	0008270	molecular_function	zinc ion binding
A	0008742	molecular_function	L-ribulose-phosphate 4-epimerase activity
A	0016832	molecular_function	aldehyde-lyase activity
A	0016853	molecular_function	isomerase activity
A	0019323	biological_process	pentose catabolic process
A	0019324	biological_process	L-lyxose metabolic process
A	0019568	biological_process	arabinose catabolic process
A	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
A	0019572	biological_process	L-arabinose catabolic process
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
B	0003824	molecular_function	catalytic activity
B	0005829	cellular_component	cytosol
B	0005996	biological_process	monosaccharide metabolic process
B	0008270	molecular_function	zinc ion binding
B	0008742	molecular_function	L-ribulose-phosphate 4-epimerase activity
B	0016832	molecular_function	aldehyde-lyase activity
B	0016853	molecular_function	isomerase activity
B	0019323	biological_process	pentose catabolic process
B	0019324	biological_process	L-lyxose metabolic process
B	0019568	biological_process	arabinose catabolic process
B	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
B	0019572	biological_process	L-arabinose catabolic process
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0003824	molecular_function	catalytic activity
C	0005829	cellular_component	cytosol
C	0005996	biological_process	monosaccharide metabolic process
C	0008270	molecular_function	zinc ion binding
C	0008742	molecular_function	L-ribulose-phosphate 4-epimerase activity
C	0016832	molecular_function	aldehyde-lyase activity
C	0016853	molecular_function	isomerase activity
C	0019323	biological_process	pentose catabolic process
C	0019324	biological_process	L-lyxose metabolic process
C	0019568	biological_process	arabinose catabolic process
C	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
C	0019572	biological_process	L-arabinose catabolic process
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
D	0003824	molecular_function	catalytic activity
D	0005829	cellular_component	cytosol
D	0005996	biological_process	monosaccharide metabolic process
D	0008270	molecular_function	zinc ion binding
D	0008742	molecular_function	L-ribulose-phosphate 4-epimerase activity
D	0016832	molecular_function	aldehyde-lyase activity
D	0016853	molecular_function	isomerase activity
D	0019323	biological_process	pentose catabolic process
D	0019324	biological_process	L-lyxose metabolic process
D	0019568	biological_process	arabinose catabolic process
D	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
D	0019572	biological_process	L-arabinose catabolic process
D	0032991	cellular_component	protein-containing complex
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
E	0003824	molecular_function	catalytic activity
E	0005829	cellular_component	cytosol
E	0005996	biological_process	monosaccharide metabolic process
E	0008270	molecular_function	zinc ion binding
E	0008742	molecular_function	L-ribulose-phosphate 4-epimerase activity
E	0016832	molecular_function	aldehyde-lyase activity
E	0016853	molecular_function	isomerase activity
E	0019323	biological_process	pentose catabolic process
E	0019324	biological_process	L-lyxose metabolic process
E	0019568	biological_process	arabinose catabolic process
E	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
E	0019572	biological_process	L-arabinose catabolic process
E	0032991	cellular_component	protein-containing complex
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
F	0003824	molecular_function	catalytic activity
F	0005829	cellular_component	cytosol
F	0005996	biological_process	monosaccharide metabolic process
F	0008270	molecular_function	zinc ion binding
F	0008742	molecular_function	L-ribulose-phosphate 4-epimerase activity
F	0016832	molecular_function	aldehyde-lyase activity
F	0016853	molecular_function	isomerase activity
F	0019323	biological_process	pentose catabolic process
F	0019324	biological_process	L-lyxose metabolic process
F	0019568	biological_process	arabinose catabolic process
F	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
F	0019572	biological_process	L-arabinose catabolic process
F	0032991	cellular_component	protein-containing complex
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	HIS95
A	HIS97
A	HIS171

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 302

Chain	Residue
B	HIS95
B	HIS97
B	HIS171
B	HOH388
B	HOH403

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 303

Chain	Residue
C	HIS97
C	HIS171
C	HOH389
C	HIS95

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 304

Chain	Residue
D	HIS95
D	HIS97
D	HIS171
D	HOH371

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN E 305

Chain	Residue
E	HIS95
E	HIS97
E	HIS171

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN F 306

Chain	Residue
F	HIS95
F	HIS97
F	HIS171

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255\|HAMAP-Rule:MF_00989, ECO:0000305\|PubMed:11732896

Chain	Residue	Details
A	ASN120
E	TYR229
F	ASN120
F	TYR229
A	TYR229
B	ASN120
B	TYR229
C	ASN120
C	TYR229
D	ASN120
D	TYR229
E	ASN120

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P0AB87, ECO:0000255\|HAMAP-Rule:MF_00989

Chain	Residue	Details
A	GLY27
D	GLY27
D	SER44
D	SER74
E	GLY27
E	SER44
E	SER74
F	GLY27
F	SER44
F	SER74
A	SER44
A	SER74
B	GLY27
B	SER44
B	SER74
C	GLY27
C	SER44
C	SER74

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00989, ECO:0000305\|PubMed:10769138, ECO:0000305\|PubMed:9548961

Chain	Residue	Details
A	ASP76
B	ASP76
C	ASP76
D	ASP76
E	ASP76
F	ASP76

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00989, ECO:0000269\|PubMed:11732895, ECO:0000269\|PubMed:11732896, ECO:0000305\|PubMed:10769138, ECO:0000305\|PubMed:10769139, ECO:0007744\|PDB:1JDI, ECO:0007744\|PDB:1K0W

Chain	Residue	Details
A	HIS95
E	HIS97
F	HIS95
F	HIS97
A	HIS97
B	HIS95
B	HIS97
C	HIS95
C	HIS97
D	HIS95
D	HIS97
E	HIS95

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00989, ECO:0000269\|PubMed:11732895, ECO:0000269\|PubMed:11732896, ECO:0000305\|PubMed:10769138, ECO:0007744\|PDB:1JDI, ECO:0007744\|PDB:1K0W

Chain	Residue	Details
A	HIS171
B	HIS171
C	HIS171
D	HIS171
E	HIS171
F	HIS171

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 273

Chain	Residue	Details
A	HIS95	metal ligand
A	HIS97	metal ligand
A	ASN120	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	HIS171	metal ligand
A	TYR229	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

site_id	MCSA2
Number of Residues	5
Details	M-CSA 273

Chain	Residue	Details
B	HIS95	metal ligand
B	HIS97	metal ligand
B	ASN120	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
B	HIS171	metal ligand
B	TYR229	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

site_id	MCSA3
Number of Residues	5
Details	M-CSA 273

Chain	Residue	Details
C	HIS95	metal ligand
C	HIS97	metal ligand
C	ASN120	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
C	HIS171	metal ligand
C	TYR229	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

site_id	MCSA4
Number of Residues	5
Details	M-CSA 273

Chain	Residue	Details
D	HIS95	metal ligand
D	HIS97	metal ligand
D	ASN120	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
D	HIS171	metal ligand
D	TYR229	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

site_id	MCSA5
Number of Residues	5
Details	M-CSA 273

Chain	Residue	Details
E	HIS95	metal ligand
E	HIS97	metal ligand
E	ASN120	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
E	HIS171	metal ligand
E	TYR229	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

site_id	MCSA6
Number of Residues	5
Details	M-CSA 273

Chain	Residue	Details
F	HIS95	metal ligand
F	HIS97	metal ligand
F	ASN120	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
F	HIS171	metal ligand
F	TYR229	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)