1JEN
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| A | 0006597 | biological_process | spermine biosynthetic process |
| A | 0008295 | biological_process | spermidine biosynthetic process |
| B | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| B | 0008295 | biological_process | spermidine biosynthetic process |
| C | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| C | 0006597 | biological_process | spermine biosynthetic process |
| C | 0008295 | biological_process | spermidine biosynthetic process |
| D | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| D | 0008295 | biological_process | spermidine biosynthetic process |
Functional Information from PDB Data
| site_id | PVL |
| Number of Residues | 2 |
| Details | THE PYRUVOYL COFACTOR IS CREATED DURING THE AUTOCATALYTIC PROENZYME CLEAVAGE REACTION, AND IS A REQUIRED FOR THE ENZYME-CATALYZED DECARBOXYLATION OF ADOMET. |
| Chain | Residue |
| A | PYR68 |
| C | PYR68 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor; for catalytic activity => ECO:0000269|PubMed:10029540, ECO:0000269|PubMed:11583147 |
| Chain | Residue | Details |
| A | CYS82 | |
| C | CYS82 | |
| D | GLU8 | |
| D | GLU11 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor; for processing activity => ECO:0000269|PubMed:11583147 |
| Chain | Residue | Details |
| A | SER229 | |
| A | HIS243 | |
| C | SER229 | |
| C | HIS243 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11583147 |
| Chain | Residue | Details |
| A | PHE223 | |
| A | GLU247 | |
| C | PHE223 | |
| C | GLU247 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER298 | |
| C | SER298 |
