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1IZN

Crystal Structure of Actin Filament Capping Protein CapZ

Functional Information from GO Data
ChainGOidnamespacecontents
A0003779molecular_functionactin binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0008290cellular_componentF-actin capping protein complex
A0030018cellular_componentZ disc
A0030036biological_processactin cytoskeleton organization
A0030863cellular_componentcortical cytoskeleton
A0034329biological_processcell junction assembly
A0051015molecular_functionactin filament binding
A0051016biological_processbarbed-end actin filament capping
A0051693biological_processactin filament capping
A0071203cellular_componentWASH complex
B0000902biological_processcell morphogenesis
B0003779molecular_functionactin binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005903cellular_componentbrush border
B0007010biological_processcytoskeleton organization
B0008154biological_processactin polymerization or depolymerization
B0008290cellular_componentF-actin capping protein complex
B0010591biological_processregulation of lamellipodium assembly
B0014069cellular_componentpostsynaptic density
B0016020cellular_componentmembrane
B0022604biological_processregulation of cell morphogenesis
B0030018cellular_componentZ disc
B0030027cellular_componentlamellipodium
B0030030biological_processcell projection organization
B0030032biological_processlamellipodium assembly
B0030036biological_processactin cytoskeleton organization
B0030863cellular_componentcortical cytoskeleton
B0031674cellular_componentI band
B0032279cellular_componentasymmetric synapse
B0051015molecular_functionactin filament binding
B0051016biological_processbarbed-end actin filament capping
B0051490biological_processnegative regulation of filopodium assembly
B0051693biological_processactin filament capping
B0071203cellular_componentWASH complex
B0097224cellular_componentsperm connecting piece
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098686cellular_componenthippocampal mossy fiber to CA3 synapse
C0003779molecular_functionactin binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0008290cellular_componentF-actin capping protein complex
C0030018cellular_componentZ disc
C0030036biological_processactin cytoskeleton organization
C0030863cellular_componentcortical cytoskeleton
C0034329biological_processcell junction assembly
C0051015molecular_functionactin filament binding
C0051016biological_processbarbed-end actin filament capping
C0051693biological_processactin filament capping
C0071203cellular_componentWASH complex
D0000902biological_processcell morphogenesis
D0003779molecular_functionactin binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005903cellular_componentbrush border
D0007010biological_processcytoskeleton organization
D0008154biological_processactin polymerization or depolymerization
D0008290cellular_componentF-actin capping protein complex
D0010591biological_processregulation of lamellipodium assembly
D0014069cellular_componentpostsynaptic density
D0016020cellular_componentmembrane
D0022604biological_processregulation of cell morphogenesis
D0030018cellular_componentZ disc
D0030027cellular_componentlamellipodium
D0030030biological_processcell projection organization
D0030032biological_processlamellipodium assembly
D0030036biological_processactin cytoskeleton organization
D0030863cellular_componentcortical cytoskeleton
D0031674cellular_componentI band
D0032279cellular_componentasymmetric synapse
D0051015molecular_functionactin filament binding
D0051016biological_processbarbed-end actin filament capping
D0051490biological_processnegative regulation of filopodium assembly
D0051693biological_processactin filament capping
D0071203cellular_componentWASH complex
D0097224cellular_componentsperm connecting piece
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098686cellular_componenthippocampal mossy fiber to CA3 synapse
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE NO3 D 1001
ChainResidue
BLYS95
CLEU275
DLEU96
DGLU99
DPRO208
DHIS209
DILE210
DHOH1086

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE NO3 B 1002
ChainResidue
BLEU96
BGLU99
BPRO208
BHIS209
BILE210
BHOH1080
DLYS95
ALEU275

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NO3 B 1003
ChainResidue
BCYS62
BASP63
BTYR71
BLYS254
BHOH1147

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NO3 D 1004
ChainResidue
DLEU40
DGLN45
DCYS62
DASP63
DTYR71

Functional Information from PROSITE/UniProt
site_idPS00231
Number of Residues6
DetailsF_ACTIN_CAPPING_BETA F-actin capping protein beta subunit signature. CDYNRD
ChainResidueDetails
BCYS62-ASP67

site_idPS00748
Number of Residues9
DetailsF_ACTIN_CAPPING_A_1 F-actin capping protein alpha subunit signature 1. VHYYEDGNV
ChainResidueDetails
AVAL196-VAL204

site_idPS00749
Number of Residues11
DetailsF_ACTIN_CAPPING_A_2 F-actin capping protein alpha subunit signature 2. KaLRRqLPVTR
ChainResidueDetails
ALYS256-ARG266

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0000250
ChainResidueDetails
BSER2
DSER2

220113

PDB entries from 2024-05-22

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