1IZ9

Crystal Structure of Malate Dehydrogenase from Thermus thermophilus HB8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0006099	biological_process	tricarboxylic acid cycle
A	0006107	biological_process	oxaloacetate metabolic process
A	0006108	biological_process	malate metabolic process
A	0006734	biological_process	NADH metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016615	molecular_function	malate dehydrogenase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
A	0030060	molecular_function	L-malate dehydrogenase activity
B	0003824	molecular_function	catalytic activity
B	0006099	biological_process	tricarboxylic acid cycle
B	0006107	biological_process	oxaloacetate metabolic process
B	0006108	biological_process	malate metabolic process
B	0006734	biological_process	NADH metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016615	molecular_function	malate dehydrogenase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019752	biological_process	carboxylic acid metabolic process
B	0030060	molecular_function	L-malate dehydrogenase activity

Functional Information from PROSITE/UniProt

site_id	PS00068
Number of Residues	13
Details	MDH Malate dehydrogenase active site signature. MTRLDhnRAkaqL

Chain	Residue	Details
A	MET155-LEU167

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01517

Chain	Residue	Details
A	HIS187
B	HIS187

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01517, ECO:0000269|PubMed:16009341, ECO:0000269|PubMed:8471603

Chain	Residue	Details
A	GLY11
A	VAL129
B	GLY11
B	VAL129

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site_id	SWS_FT_FI3
Number of Residues	10
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01517

Chain	Residue	Details
A	ARG92
B	ARG162
A	ARG98
A	ASN105
A	ASN131
A	ARG162
B	ARG92
B	ARG98
B	ASN105
B	ASN131

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01517, ECO:0000269|PubMed:16009341

Chain	Residue	Details
A	GLN112
B	GLN112

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