1INF

INFLUENZA VIRUS B/LEE/40 NEURAMINIDASE COMPLEXED WITH BANA113 INHIBITOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004308	molecular_function	exo-alpha-sialidase activity
A	0005975	biological_process	carbohydrate metabolic process
A	0016020	cellular_component	membrane
A	0033644	cellular_component	host cell membrane
A	0055036	cellular_component	virion membrane

Functional Information from PDB Data

site_id	CAT
Number of Residues	11
Details	SUBSTRATE (SIALIC ACID) BINDING RESIDUES CATALYTIC SITE

Chain	Residue
A	ARG116
A	ARG374
A	TYR409
A	GLU117
A	ASP149
A	ARG150
A	TRP177
A	ILE221
A	ARG223
A	GLU275
A	ARG292

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ASP149

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	TYR409

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site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ARG116
A	ARG150
A	GLU275
A	ARG292
A	ARG374

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:10547289, ECO:0000269|PubMed:7880809

Chain	Residue	Details
A	ASP293
A	ASP324

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site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:10547289, ECO:0000269|PubMed:7880809

Chain	Residue	Details
A	THR297
A	GLY346

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ASN144
A	ASN284

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