Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1I7Q

ANTHRANILATE SYNTHASE FROM S. MARCESCENS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000162	biological_process	tryptophan biosynthetic process
A	0004049	molecular_function	anthranilate synthase activity
A	0005515	molecular_function	protein binding
A	0008152	biological_process	metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding
B	0000162	biological_process	tryptophan biosynthetic process
B	0002047	biological_process	phenazine biosynthetic process
B	0004048	molecular_function	anthranilate phosphoribosyltransferase activity
B	0004049	molecular_function	anthranilate synthase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006541	biological_process	glutamine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0016829	molecular_function	lyase activity
B	0018130	biological_process	obsolete heterocycle biosynthetic process
B	0019438	biological_process	obsolete aromatic compound biosynthetic process
B	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
B	1901362	biological_process	organic cyclic compound biosynthetic process
B	1901566	biological_process	organonitrogen compound biosynthetic process
C	0000162	biological_process	tryptophan biosynthetic process
C	0004049	molecular_function	anthranilate synthase activity
C	0005515	molecular_function	protein binding
C	0008152	biological_process	metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009058	biological_process	biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0016829	molecular_function	lyase activity
C	0046872	molecular_function	metal ion binding
D	0000162	biological_process	tryptophan biosynthetic process
D	0002047	biological_process	phenazine biosynthetic process
D	0004048	molecular_function	anthranilate phosphoribosyltransferase activity
D	0004049	molecular_function	anthranilate synthase activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006541	biological_process	glutamine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0016829	molecular_function	lyase activity
D	0018130	biological_process	obsolete heterocycle biosynthetic process
D	0019438	biological_process	obsolete aromatic compound biosynthetic process
D	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
D	1901362	biological_process	organic cyclic compound biosynthetic process
D	1901566	biological_process	organonitrogen compound biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1701

Chain	Residue
A	GLU361
A	GLU498
A	BEZ1501
A	HOH1760
A	HOH1898

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 1702

Chain	Residue
C	HOH1719
C	GLU361
C	GLU498
C	BEZ1502
C	HOH1716

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 1401

Chain	Residue
A	GLY259
B	PRO57
B	GLY58
B	PRO59
B	GLY60
B	CYS85
B	LEU86
B	GLN89
B	TYR133
B	HIS134
B	SER135
B	LEU136
B	HOH1547

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU D 1402

Chain	Residue
C	GLY259
D	PRO57
D	GLY58
D	PRO59
D	GLY60
D	CYS85
D	LEU86
D	GLN89
D	TYR133
D	HIS134
D	SER135
D	LEU136

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BEZ A 1501

Chain	Residue
A	GLU309
A	ILE326
A	GLY328
A	THR329
A	GLU361
A	THR425
A	ARG469
A	ALA484
A	GLY485
A	GLU498
A	LYS502
A	PYR1601
A	MG1701
A	HOH1881

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BEZ C 1502

Chain	Residue
C	GLU309
C	ILE326
C	GLY328
C	THR329
C	GLU361
C	HIS398
C	THR425
C	ARG469
C	GLY485
C	GLU498
C	LYS502
C	PYR1602
C	MG1702
C	HOH1922

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PYR A 1601

Chain	Residue
A	TYR449
A	ILE468
A	ARG469
A	ALA482
A	GLY483
A	LYS502
A	BEZ1501
A	HOH1702

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PYR C 1602

Chain	Residue
C	VAL265
C	TYR449
C	ILE468
C	ARG469
C	ALA482
C	GLY483
C	LYS502
C	BEZ1502
C	HOH1711

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile; for GATase activity => ECO:0000269\|PubMed:11371633

Chain	Residue	Details
B	CYS85
D	CYS85
C	SER40
C	PRO291

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: For GATase activity => ECO:0000255\|PROSITE-ProRule:PRU00605

Chain	Residue	Details
B	HIS172
C	GLY485
B	GLU174
D	HIS172
D	GLU174
A	GLY485
C	GLY328
C	TYR449
C	ARG469
C	GLY483

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305\|PubMed:11371633

Chain	Residue	Details
B	GLY58
B	GLN89
B	SER135
D	GLY58
D	GLN89
D	SER135

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)