1HTT

HISTIDYL-TRNA SYNTHETASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004821	molecular_function	histidine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006427	biological_process	histidyl-tRNA aminoacylation
A	0042803	molecular_function	protein homodimerization activity
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004821	molecular_function	histidine-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0006427	biological_process	histidyl-tRNA aminoacylation
B	0042803	molecular_function	protein homodimerization activity
C	0004812	molecular_function	aminoacyl-tRNA ligase activity
C	0004821	molecular_function	histidine-tRNA ligase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006412	biological_process	translation
C	0006427	biological_process	histidyl-tRNA aminoacylation
C	0042803	molecular_function	protein homodimerization activity
D	0004812	molecular_function	aminoacyl-tRNA ligase activity
D	0004821	molecular_function	histidine-tRNA ligase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006412	biological_process	translation
D	0006427	biological_process	histidyl-tRNA aminoacylation
D	0042803	molecular_function	protein homodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE HIS A 450

Chain	Residue
A	GLU83
A	THR85
A	GLN127
A	GLU131
A	TYR263
A	TYR264
A	ALA284
A	AMP451

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HIS B 450

Chain	Residue
B	GLU83
B	THR85
B	GLN127
B	GLU131
B	LEU261
B	TYR263
B	TYR264
B	TYR288
B	GLY304
B	PHE305
B	AMP451
B	HOH504

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HIS C 450

Chain	Residue
C	GLU83
C	THR85
C	GLN127
C	GLU131
C	LEU261
C	TYR263
C	TYR264
C	GLY304
C	PHE305
C	AMP451

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HIS D 450

Chain	Residue
D	THR85
D	GLN127
D	GLU131
D	ARG259
D	TYR263
D	TYR264
D	ALA284
D	GLY285
D	GLY304
D	PHE305
D	AMP451
D	HOH611
D	GLU83

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE AMP A 451

Chain	Residue
A	ARG113
A	GLU115
A	GLY120
A	ARG121
A	TYR122
A	PHE125
A	GLN127
A	ARG259
A	LEU261
A	THR281
A	VAL282
A	GLY308
A	ARG311
A	HIS450
A	HOH594

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE AMP B 451

Chain	Residue
B	ARG113
B	GLU115
B	GLY120
B	ARG121
B	TYR122
B	PHE125
B	GLN127
B	ARG259
B	LEU261
B	THR281
B	VAL282
B	GLY308
B	ARG311
B	HIS450
B	HOH505

---

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE AMP C 451

Chain	Residue
C	ARG113
C	GLU115
C	GLY120
C	ARG121
C	TYR122
C	PHE125
C	GLN127
C	ARG259
C	THR281
C	VAL282
C	ALA284
C	GLY308
C	ARG311
C	HIS450
C	HOH624
C	HOH627

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AMP D 451

Chain	Residue
D	ARG113
D	GLU115
D	GLY120
D	ARG121
D	TYR122
D	PHE125
D	GLN127
D	ARG259
D	THR281
D	VAL282
D	GLY308
D	ARG311
D	HIS450

---

site_id	S1A
Number of Residues	17
Details	HISTIDINE AND ATP BINDING SITES, PRODUCT OF THE FIRST REACTION (INTERMEDIATE IN THE OVERALL REACTION):HISTIDYL-ADENYLATE (OBSERVED IN THE SITE).

Chain	Residue
A	GLU83
A	ARG259
A	TYR263
A	TYR264
A	GLU270
A	THR281
A	TYR288
A	ARG311
A	HIS450
A	THR85
A	ARG113
A	GLU115
A	ARG121
A	TYR122
A	PHE125
A	GLN127
A	GLU131

---

site_id	S1B
Number of Residues	17
Details	HISTIDINE AND ATP BINDING SITES, PRODUCT OF THE FIRST REACTION (INTERMEDIATE IN THE OVERALL REACTION):HISTIDYL-ADENYLATE (OBSERVED IN THE SITE).

Chain	Residue
B	GLU83
B	THR85
B	ARG113
B	GLU115
B	ARG121
B	TYR122
B	PHE125
B	GLN127
B	GLU131
B	ARG259
B	TYR263
B	TYR264
B	GLU270
B	THR281
B	TYR288
B	ARG311
B	HIS450

---

site_id	S1C
Number of Residues	17
Details	HISTIDINE AND ATP BINDING SITES, PRODUCT OF THE FIRST REACTION (INTERMEDIATE IN THE OVERALL REACTION):HISTIDYL-ADENYLATE (OBSERVED IN THE SITE).

Chain	Residue
C	GLU83
C	THR85
C	ARG113
C	GLU115
C	ARG121
C	TYR122
C	PHE125
C	GLN127
C	GLU131
C	ARG259
C	TYR263
C	TYR264
C	GLU270
C	THR281
C	TYR288
C	ARG311
C	HIS450

---

site_id	S1D
Number of Residues	17
Details	HISTIDINE AND ATP BINDING SITES, PRODUCT OF THE FIRST REACTION (INTERMEDIATE IN THE OVERALL REACTION):HISTIDYL-ADENYLATE (OBSERVED IN THE SITE).

Chain	Residue
D	GLU83
D	THR85
D	ARG113
D	GLU115
D	ARG121
D	TYR122
D	PHE125
D	GLN127
D	GLU131
D	ARG259
D	TYR263
D	TYR264
D	GLU270
D	THR281
D	TYR288
D	ARG311
D	HIS450

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
A	ARG113

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
B	ARG113

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site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
C	ARG113

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site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
D	ARG113

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