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1HPT

THREE-DIMENSIONAL STRUCTURE OF A RECOMBINANT VARIANT OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL TYPE)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004866molecular_functionendopeptidase inhibitor activity
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007263biological_processnitric oxide mediated signal transduction
A0010751biological_processnegative regulation of nitric oxide mediated signal transduction
A0030414molecular_functionpeptidase inhibitor activity
A0031667biological_processresponse to nutrient levels
A0045471biological_processresponse to ethanol
A0048240biological_processsperm capacitation
A0050679biological_processpositive regulation of epithelial cell proliferation
A0050732biological_processnegative regulation of peptidyl-tyrosine phosphorylation
A0060046biological_processregulation of acrosome reaction
A0070062cellular_componentextracellular exosome
A0071375biological_processcellular response to peptide hormone stimulus
A0090187biological_processpositive regulation of pancreatic juice secretion
A0090277biological_processpositive regulation of peptide hormone secretion
A0090281biological_processnegative regulation of calcium ion import
A2001256biological_processregulation of store-operated calcium entry
Functional Information from PROSITE/UniProt
site_idPS00282
Number of Residues23
DetailsKAZAL_1 Kazal serine protease inhibitors family signature. CtyeyRpvCgTdgdtYpneCvl.C
ChainResidueDetails
ACYS16-CYS38

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Reactive bond for trypsin => ECO:0000250|UniProtKB:P09036, ECO:0000255|PROSITE-ProRule:PRU00798
ChainResidueDetails
ATYR18

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Necessary for sperm binding => ECO:0000250|UniProtKB:P09036
ChainResidueDetails
ATYR20

218853

PDB entries from 2024-04-24

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