1HG3
Crystal structure of tetrameric TIM from Pyrococcus woesei.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004807 | molecular_function | triose-phosphate isomerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019563 | biological_process | glycerol catabolic process |
| A | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| B | 0004807 | molecular_function | triose-phosphate isomerase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019563 | biological_process | glycerol catabolic process |
| B | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| C | 0004807 | molecular_function | triose-phosphate isomerase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006094 | biological_process | gluconeogenesis |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0019563 | biological_process | glycerol catabolic process |
| C | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| D | 0004807 | molecular_function | triose-phosphate isomerase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006094 | biological_process | gluconeogenesis |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0019563 | biological_process | glycerol catabolic process |
| D | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| E | 0004807 | molecular_function | triose-phosphate isomerase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006094 | biological_process | gluconeogenesis |
| E | 0006096 | biological_process | glycolytic process |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0019563 | biological_process | glycerol catabolic process |
| E | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| F | 0004807 | molecular_function | triose-phosphate isomerase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006094 | biological_process | gluconeogenesis |
| F | 0006096 | biological_process | glycolytic process |
| F | 0016853 | molecular_function | isomerase activity |
| F | 0019563 | biological_process | glycerol catabolic process |
| F | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| G | 0004807 | molecular_function | triose-phosphate isomerase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0006094 | biological_process | gluconeogenesis |
| G | 0006096 | biological_process | glycolytic process |
| G | 0016853 | molecular_function | isomerase activity |
| G | 0019563 | biological_process | glycerol catabolic process |
| G | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| H | 0004807 | molecular_function | triose-phosphate isomerase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0006094 | biological_process | gluconeogenesis |
| H | 0006096 | biological_process | glycolytic process |
| H | 0016853 | molecular_function | isomerase activity |
| H | 0019563 | biological_process | glycerol catabolic process |
| H | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 3PP A1226 |
| Chain | Residue |
| A | ASN12 |
| A | SER206 |
| A | HOH2036 |
| A | HOH2037 |
| A | LYS14 |
| A | HIS96 |
| A | GLU144 |
| A | ILE149 |
| A | ALA183 |
| A | GLY184 |
| A | LEU204 |
| A | ALA205 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 3PP B1226 |
| Chain | Residue |
| B | ASN12 |
| B | LYS14 |
| B | HIS96 |
| B | GLU144 |
| B | ILE149 |
| B | ALA183 |
| B | GLY184 |
| B | LEU203 |
| B | LEU204 |
| B | ALA205 |
| B | SER206 |
| B | HOH2036 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 3PP C1226 |
| Chain | Residue |
| C | ASN12 |
| C | LYS14 |
| C | HIS96 |
| C | GLU144 |
| C | ILE149 |
| C | ALA183 |
| C | GLY184 |
| C | LEU204 |
| C | ALA205 |
| C | SER206 |
| C | HOH2004 |
| C | HOH2048 |
| C | HOH2052 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 3PP D1226 |
| Chain | Residue |
| D | ASN12 |
| D | LYS14 |
| D | HIS96 |
| D | GLU144 |
| D | ILE149 |
| D | GLY184 |
| D | LEU203 |
| D | LEU204 |
| D | ALA205 |
| D | SER206 |
| D | GLY207 |
| D | HOH2044 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 3PP E1226 |
| Chain | Residue |
| E | ASN12 |
| E | LYS14 |
| E | HIS96 |
| E | GLU144 |
| E | ILE149 |
| E | ALA183 |
| E | GLY184 |
| E | LEU203 |
| E | LEU204 |
| E | ALA205 |
| E | SER206 |
| E | HOH2043 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 3PP F1226 |
| Chain | Residue |
| F | ASN12 |
| F | LYS14 |
| F | HIS96 |
| F | GLU144 |
| F | ILE149 |
| F | ALA183 |
| F | GLY184 |
| F | LEU203 |
| F | LEU204 |
| F | ALA205 |
| F | SER206 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 3PP G1226 |
| Chain | Residue |
| G | ASN12 |
| G | LYS14 |
| G | HIS96 |
| G | GLU144 |
| G | ILE149 |
| G | ALA183 |
| G | GLY184 |
| G | LEU204 |
| G | ALA205 |
| G | SER206 |
| G | HOH2045 |
| G | HOH2046 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 3PP H1226 |
| Chain | Residue |
| H | ASN12 |
| H | LYS14 |
| H | HIS96 |
| H | GLU144 |
| H | ILE149 |
| H | ALA183 |
| H | GLY184 |
| H | LEU203 |
| H | LEU204 |
| H | ALA205 |
| H | SER206 |
| H | HOH2003 |
| H | HOH2044 |
Functional Information from PROSITE/UniProt
| site_id | PS00171 |
| Number of Residues | 11 |
| Details | TIM_1 Triosephosphate isomerase active site. AVEPPELIGTG |
| Chain | Residue | Details |
| A | ALA142-GLY152 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Electrophile => ECO:0000255|HAMAP-Rule:MF_00147 |
| Chain | Residue | Details |
| A | HIS96 | |
| B | HIS96 | |
| C | HIS96 | |
| D | HIS96 | |
| E | HIS96 | |
| F | HIS96 | |
| G | HIS96 | |
| H | HIS96 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00147 |
| Chain | Residue | Details |
| A | GLU144 | |
| B | GLU144 | |
| C | GLU144 | |
| D | GLU144 | |
| E | GLU144 | |
| F | GLU144 | |
| G | GLU144 | |
| H | GLU144 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00147, ECO:0000269|PubMed:11243785 |
| Chain | Residue | Details |
| A | ASN12 | |
| D | ASN12 | |
| D | ILE149 | |
| D | ALA205 | |
| E | ASN12 | |
| E | ILE149 | |
| E | ALA205 | |
| F | ASN12 | |
| F | ILE149 | |
| F | ALA205 | |
| G | ASN12 | |
| A | ILE149 | |
| G | ILE149 | |
| G | ALA205 | |
| H | ASN12 | |
| H | ILE149 | |
| H | ALA205 | |
| A | ALA205 | |
| B | ASN12 | |
| B | ILE149 | |
| B | ALA205 | |
| C | ASN12 | |
| C | ILE149 | |
| C | ALA205 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00147 |
| Chain | Residue | Details |
| A | GLY184 | |
| B | GLY184 | |
| C | GLY184 | |
| D | GLY184 | |
| E | GLY184 | |
| F | GLY184 | |
| G | GLY184 | |
| H | GLY184 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1hti |
| Chain | Residue | Details |
| A | LYS14 | |
| A | HIS96 | |
| A | GLU144 | |
| A | GLY150 | |
| A | ASN12 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1hti |
| Chain | Residue | Details |
| B | LYS14 | |
| B | HIS96 | |
| B | GLU144 | |
| B | GLY150 | |
| B | ASN12 |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1hti |
| Chain | Residue | Details |
| C | LYS14 | |
| C | HIS96 | |
| C | GLU144 | |
| C | GLY150 | |
| C | ASN12 |
| site_id | CSA4 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1hti |
| Chain | Residue | Details |
| D | LYS14 | |
| D | HIS96 | |
| D | GLU144 | |
| D | GLY150 | |
| D | ASN12 |
| site_id | CSA5 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1hti |
| Chain | Residue | Details |
| E | LYS14 | |
| E | HIS96 | |
| E | GLU144 | |
| E | GLY150 | |
| E | ASN12 |
| site_id | CSA6 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1hti |
| Chain | Residue | Details |
| F | LYS14 | |
| F | HIS96 | |
| F | GLU144 | |
| F | GLY150 | |
| F | ASN12 |
| site_id | CSA7 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1hti |
| Chain | Residue | Details |
| G | LYS14 | |
| G | HIS96 | |
| G | GLU144 | |
| G | GLY150 | |
| G | ASN12 |
| site_id | CSA8 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1hti |
| Chain | Residue | Details |
| H | LYS14 | |
| H | HIS96 | |
| H | GLU144 | |
| H | GLY150 | |
| H | ASN12 |
