1GZX

Oxy T State Haemoglobin - Oxygen bound at all four haems

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005829	cellular_component	cytosol
A	0005833	cellular_component	hemoglobin complex
A	0015670	biological_process	carbon dioxide transport
A	0015671	biological_process	oxygen transport
A	0016020	cellular_component	membrane
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0030185	biological_process	nitric oxide transport
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0071682	cellular_component	endocytic vesicle lumen
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005829	cellular_component	cytosol
B	0005833	cellular_component	hemoglobin complex
B	0008217	biological_process	regulation of blood pressure
B	0015670	biological_process	carbon dioxide transport
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0030185	biological_process	nitric oxide transport
B	0030492	molecular_function	hemoglobin binding
B	0031720	molecular_function	haptoglobin binding
B	0031721	molecular_function	hemoglobin alpha binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042542	biological_process	response to hydrogen peroxide
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0043177	molecular_function	organic acid binding
B	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0070293	biological_process	renal absorption
B	0070527	biological_process	platelet aggregation
B	0071682	cellular_component	endocytic vesicle lumen
B	0072562	cellular_component	blood microparticle
B	0097746	biological_process	blood vessel diameter maintenance
B	0098869	biological_process	cellular oxidant detoxification
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0004601	molecular_function	peroxidase activity
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005829	cellular_component	cytosol
C	0005833	cellular_component	hemoglobin complex
C	0015670	biological_process	carbon dioxide transport
C	0015671	biological_process	oxygen transport
C	0016020	cellular_component	membrane
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0030185	biological_process	nitric oxide transport
C	0031720	molecular_function	haptoglobin binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0042542	biological_process	response to hydrogen peroxide
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0043177	molecular_function	organic acid binding
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0071682	cellular_component	endocytic vesicle lumen
C	0072562	cellular_component	blood microparticle
C	0098869	biological_process	cellular oxidant detoxification
D	0004601	molecular_function	peroxidase activity
D	0005344	molecular_function	oxygen carrier activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005829	cellular_component	cytosol
D	0005833	cellular_component	hemoglobin complex
D	0008217	biological_process	regulation of blood pressure
D	0015670	biological_process	carbon dioxide transport
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0030185	biological_process	nitric oxide transport
D	0030492	molecular_function	hemoglobin binding
D	0031720	molecular_function	haptoglobin binding
D	0031721	molecular_function	hemoglobin alpha binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0042542	biological_process	response to hydrogen peroxide
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0043177	molecular_function	organic acid binding
D	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0070293	biological_process	renal absorption
D	0070527	biological_process	platelet aggregation
D	0071682	cellular_component	endocytic vesicle lumen
D	0072562	cellular_component	blood microparticle
D	0097746	biological_process	blood vessel diameter maintenance
D	0098869	biological_process	cellular oxidant detoxification
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM A1142

Chain	Residue
A	TYR42
A	HIS87
A	LEU91
A	VAL93
A	ASN97
A	PHE98
A	LEU136
A	OXY1143
A	HOH2029
A	PHE43
A	HIS45
A	PHE46
A	HIS58
A	LYS61
A	ALA65
A	LEU83
A	LEU86

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM B1290

Chain	Residue
A	HIS72
A	ASP75
A	HOH2040
B	HIS206
B	LYS209
B	VAL210
B	LEU234
B	HIS235
B	LEU239
B	VAL241
B	ASN245
B	PHE246
B	LEU284
B	OXY1291
B	HOH2053
B	HOH2054
B	HOH2055

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM C1542

Chain	Residue
B	LYS160
C	TYR442
C	PHE443
C	HIS445
C	HIS458
C	LYS461
C	ALA465
C	LEU486
C	HIS487
C	LEU491
C	VAL493
C	ASN497
C	PHE498
C	LEU536
C	OXY1543
C	HOH2043
C	HOH2045

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HEM D1690

Chain	Residue
C	LYS456
D	PHE584
D	PHE585
D	HIS606
D	LYS609
D	HIS635
D	LEU639
D	ASN645
D	PHE646
D	LEU649
D	LEU684
D	OXY1691

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OXY A1143

Chain	Residue
A	HIS58
A	VAL62
A	HEM1142

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OXY B1291

Chain	Residue
B	HIS206
B	VAL210
B	HEM1290

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OXY C1543

Chain	Residue
C	HIS458
C	VAL462
C	HEM1542

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OXY D1691

Chain	Residue
D	HIS606
D	VAL610
D	HEM1690

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
B	VAL144
B	HIS145
B	LYS225
B	HIS286
D	VAL544
D	HIS545
D	LYS625
D	HIS686

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: distal binding residue

Chain	Residue	Details
B	HIS206
D	HIS606

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: proximal binding residue

Chain	Residue	Details
B	HIS235
A	LEU91
A	LEU106
A	THR108
A	VAL121
A	SER133
C	THR408
C	ALA413
C	TYR424
C	LEU429
C	HIS445
D	HIS635
C	ASP447
C	SER452
C	VAL455
C	GLY459
C	LEU491
C	LEU506
C	THR508
C	VAL521
C	SER533
A	TYR24
A	LEU29
A	HIS45
A	ASP47
A	SER52
A	VAL55
A	GLY59

---

site_id	SWS_FT_FI4
Number of Residues	38
Details	SITE: (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433

Chain	Residue	Details
B	GLU150
B	GLY217
B	THR227
B	HIS235
B	ARG247
B	LEU253
B	GLY262
B	PHE265
B	ALA271
B	ALA283
B	LYS287
B	GLY168
D	GLU550
D	GLY568
D	GLY572
D	TYR578
D	TRP580
D	PHE588
D	ASP595
D	GLY599
D	PHE614
D	GLY617
B	GLY172
D	THR627
D	HIS635
D	ARG647
D	LEU653
D	GLY662
D	PHE665
D	ALA671
D	ALA683
D	LYS687
B	TYR178
B	TRP180
B	PHE188
B	ASP195
B	GLY199
B	PHE214

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	SITE: Not glycated => ECO:0000269|PubMed:7358733

Chain	Residue	Details
B	LYS202
B	LYS225
B	LYS238
D	LYS602
D	LYS625
D	LYS638

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N-pyruvate 2-iminyl-valine; in Hb A1b

Chain	Residue	Details
B	VAL144
D	VAL544
A	LYS40
C	LYS407
C	LYS416
C	LYS440

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER152
B	SER187
D	SER552
D	SER587

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	THR155
B	THR193
B	THR230
D	THR555
D	THR593
D	THR630

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:4531009

Chain	Residue	Details
B	LYS202
B	LYS225
D	LYS602
D	LYS625

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411

Chain	Residue	Details
B	CYS236
D	CYS636
A	SER131
A	SER138
C	SER502
C	SER524
C	SER531
C	SER538

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009

Chain	Residue	Details
B	LYS287
D	LYS687
A	THR137
C	THR508
C	THR534
C	THR537

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569

Chain	Residue	Details
B	VAL144
D	VAL544
A	LYS40
C	LYS407
C	LYS416
C	LYS440

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733

Chain	Residue	Details
B	LYS151
B	LYS160
B	LYS209
B	LYS263
D	LYS551
D	LYS560
D	LYS609
D	LYS663

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733

Chain	Residue	Details
B	LYS287
D	LYS687

---