1GLL

ESCHERICHIA COLI GLYCEROL KINASE MUTANT WITH BOUND ATP ANALOG SHOWING SUBSTANTIAL DOMAIN MOTION

Functional Information from GO Data

Chain	GOid	namespace	contents
O	0004370	molecular_function	glycerol kinase activity
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005829	cellular_component	cytosol
O	0005975	biological_process	carbohydrate metabolic process
O	0006071	biological_process	glycerol metabolic process
O	0006072	biological_process	glycerol-3-phosphate metabolic process
O	0006974	biological_process	DNA damage response
O	0008270	molecular_function	zinc ion binding
O	0016301	molecular_function	kinase activity
O	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
O	0019563	biological_process	glycerol catabolic process
O	0042802	molecular_function	identical protein binding
O	0046872	molecular_function	metal ion binding
Y	0004370	molecular_function	glycerol kinase activity
Y	0005515	molecular_function	protein binding
Y	0005524	molecular_function	ATP binding
Y	0005829	cellular_component	cytosol
Y	0005975	biological_process	carbohydrate metabolic process
Y	0006071	biological_process	glycerol metabolic process
Y	0006072	biological_process	glycerol-3-phosphate metabolic process
Y	0006974	biological_process	DNA damage response
Y	0008270	molecular_function	zinc ion binding
Y	0016301	molecular_function	kinase activity
Y	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
Y	0019563	biological_process	glycerol catabolic process
Y	0042802	molecular_function	identical protein binding
Y	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	PUTATIVE PROTON ACCEPTOR FROM NUCLEOPHILIC O3 POSITION OF GLYCEROL, CHAIN Y.

Chain	Residue
O	ASP245

---

site_id	AC2
Number of Residues	1
Details	PUTATIVE PROTON ACCEPTOR FROM NUCLEOPHILIC O3 POSITION OF GLYCEROL, CHAIN O.

Chain	Residue
Y	ASP245

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG Y 602

Chain	Residue
Y	ACP601

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG O 602

Chain	Residue
O	ASP245
O	ACP601

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ACP Y 601

Chain	Residue
Y	THR267
Y	GLY310
Y	ALA311
Y	ILE313
Y	GLN314
Y	ALA326
Y	TYR327
Y	SER329
Y	GLY411
Y	ALA412
Y	ASN415
Y	MG602
Y	GLY12
Y	THR13
Y	THR14
Y	GLY266

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ACP O 601

Chain	Residue
O	GLY12
O	THR13
O	THR14
O	GLY266
O	THR267
O	GLY310
O	ALA311
O	ILE313
O	GLN314
O	GLY411
O	ASN415
O	MG602

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL Y 600

Chain	Residue
Y	GLN82
Y	ARG83
Y	GLU84
Y	TYR135
Y	ASP245
Y	GLN246
Y	PHE270

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL O 600

Chain	Residue
O	THR13
O	ASN81
O	GLN82
O	ARG83
O	GLU84
O	TYR135
O	ASP245
O	GLN246

---

Functional Information from PROSITE/UniProt

site_id	PS00445
Number of Residues	21
Details	FGGY_KINASES_2 FGGY family of carbohydrate kinases signature 2. GaIFGLtrgvnan.HIIRATLE

Chain	Residue	Details
Y	GLY362-GLU382

---

site_id	PS00933
Number of Residues	13
Details	FGGY_KINASES_1 FGGY family of carbohydrate kinases signature 1. YfSgtKVKWILDH

Chain	Residue	Details
Y	TYR135-HIS147

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:8170944, ECO:0007744|PDB:1GLC, ECO:0007744|PDB:1GLD, ECO:0007744|PDB:1GLE

Chain	Residue	Details
Y	THR14
Y	GLU84
O	PHE136
O	GLN246
O	ARG479
Y	GLN246
Y	ARG479
O	THR14
O	GLU84
O	THR85
Y	THR85
Y	PHE136

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:10090737, ECO:0007744|PDB:1BWF, ECO:0007744|PDB:1GLJ, ECO:0007744|PDB:1GLL

Chain	Residue	Details
O	SER15
O	ALA412
Y	SER15
Y	ALA412

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:10090737, ECO:0007744|PDB:1GLJ

Chain	Residue	Details
Y	SER16
O	SER16

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8170944, ECO:0000269|PubMed:8430315, ECO:0000269|PubMed:9817843, ECO:0007744|PDB:1GLB, ECO:0007744|PDB:1GLD, ECO:0007744|PDB:1GLE, ECO:0007744|PDB:1GLF

Chain	Residue	Details
Y	ALA18
O	ALA18

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:9843423, ECO:0007744|PDB:1BO5

Chain	Residue	Details
Y	THR235
Y	ILE237
O	THR235
O	ILE237

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8430315, ECO:0000269|PubMed:9843423, ECO:0007744|PDB:1BO5, ECO:0007744|PDB:1BOT

Chain	Residue	Details
Y	GLN247
O	GLN247

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305|PubMed:10090737, ECO:0007744|PDB:1BWF, ECO:0007744|PDB:1GLL

Chain	Residue	Details
Y	GLY268
Y	ALA311
Y	TRP315
O	GLY268
O	ALA311
O	TRP315

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8170944, ECO:0000269|PubMed:8430315, ECO:0007744|PDB:1GLB, ECO:0007744|PDB:1GLC, ECO:0007744|PDB:1GLD, ECO:0007744|PDB:1GLE

Chain	Residue	Details
Y	ASN416
O	ASN416

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: N6-malonyllysine => ECO:0000269|PubMed:21908771

Chain	Residue	Details
Y	GLY233
O	GLY233

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