1FA9
HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH AMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002060 | molecular_function | purine nucleobase binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005536 | molecular_function | glucose binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0005977 | biological_process | glycogen metabolic process |
| A | 0005980 | biological_process | glycogen catabolic process |
| A | 0006015 | biological_process | 5-phosphoribose 1-diphosphate biosynthetic process |
| A | 0008152 | biological_process | metabolic process |
| A | 0008184 | molecular_function | glycogen phosphorylase activity |
| A | 0009617 | biological_process | response to bacterium |
| A | 0016208 | molecular_function | AMP binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0019842 | molecular_function | vitamin binding |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0032052 | molecular_function | bile acid binding |
| A | 0034774 | cellular_component | secretory granule lumen |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070266 | biological_process | necroptotic process |
| A | 0102250 | molecular_function | linear malto-oligosaccharide phosphorylase activity |
| A | 0102499 | molecular_function | SHG alpha-glucan phosphorylase activity |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PROSITE/UniProt
| site_id | PS00102 |
| Number of Residues | 13 |
| Details | PHOSPHORYLASE Phosphorylase pyridoxal-phosphate attachment site. EASGtGnMKfmLN |
| Chain | Residue | Details |
| A | GLU672-ASN684 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10949035, ECO:0007744|PDB:1FA9 |
| Chain | Residue | Details |
| A | ASP42 | |
| A | TYR75 | |
| A | ARG309 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Involved in the association of subunits => ECO:0000250|UniProtKB:P00489 |
| Chain | Residue | Details |
| A | CYS108 | |
| A | CYS142 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: May be involved in allosteric control => ECO:0000250|UniProtKB:P00489 |
| Chain | Residue | Details |
| A | TYR155 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| A | ALA1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PHK; in form phosphorylase a => ECO:0000269|PubMed:10949035, ECO:0000269|PubMed:22225877, ECO:0007744|PDB:1FA9 |
| Chain | Residue | Details |
| A | SEP14 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9ET01 |
| Chain | Residue | Details |
| A | LYS363 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22225877 |
| Chain | Residue | Details |
| A | LYS469 | |
| A | LYS795 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9ET01 |
| Chain | Residue | Details |
| A | SER523 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09811 |
| Chain | Residue | Details |
| A | SER560 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER638 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:10949035, ECO:0000269|PubMed:10980448, ECO:0000269|PubMed:12204691, ECO:0007744|PDB:1EM6, ECO:0007744|PDB:1EXV, ECO:0007744|PDB:1FA9, ECO:0007744|PDB:1FC0, ECO:0007744|PDB:1L5Q, ECO:0007744|PDB:1L5R, ECO:0007744|PDB:1L5S, ECO:0007744|PDB:1L7X |
| Chain | Residue | Details |
| A | LYS680 |
