1DCO

DCOH, A BIFUNCTIONAL PROTEIN-BINDING TRANSCRIPTIONAL COACTIVATOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003713	molecular_function	transcription coactivator activity
A	0004505	molecular_function	phenylalanine 4-monooxygenase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006558	biological_process	L-phenylalanine metabolic process
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
A	0008150	biological_process	biological_process
A	0016829	molecular_function	lyase activity
A	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
A	0042802	molecular_function	identical protein binding
A	0043393	biological_process	regulation of protein binding
A	0045893	biological_process	positive regulation of DNA-templated transcription
B	0003713	molecular_function	transcription coactivator activity
B	0004505	molecular_function	phenylalanine 4-monooxygenase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006558	biological_process	L-phenylalanine metabolic process
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
B	0008150	biological_process	biological_process
B	0016829	molecular_function	lyase activity
B	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
B	0042802	molecular_function	identical protein binding
B	0043393	biological_process	regulation of protein binding
B	0045893	biological_process	positive regulation of DNA-templated transcription
C	0003713	molecular_function	transcription coactivator activity
C	0004505	molecular_function	phenylalanine 4-monooxygenase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006558	biological_process	L-phenylalanine metabolic process
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
C	0008150	biological_process	biological_process
C	0016829	molecular_function	lyase activity
C	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
C	0042802	molecular_function	identical protein binding
C	0043393	biological_process	regulation of protein binding
C	0045893	biological_process	positive regulation of DNA-templated transcription
D	0003713	molecular_function	transcription coactivator activity
D	0004505	molecular_function	phenylalanine 4-monooxygenase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006558	biological_process	L-phenylalanine metabolic process
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
D	0008150	biological_process	biological_process
D	0016829	molecular_function	lyase activity
D	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
D	0042802	molecular_function	identical protein binding
D	0043393	biological_process	regulation of protein binding
D	0045893	biological_process	positive regulation of DNA-templated transcription
E	0003713	molecular_function	transcription coactivator activity
E	0004505	molecular_function	phenylalanine 4-monooxygenase activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006558	biological_process	L-phenylalanine metabolic process
E	0006729	biological_process	tetrahydrobiopterin biosynthetic process
E	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
E	0008150	biological_process	biological_process
E	0016829	molecular_function	lyase activity
E	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
E	0042802	molecular_function	identical protein binding
E	0043393	biological_process	regulation of protein binding
E	0045893	biological_process	positive regulation of DNA-templated transcription
F	0003713	molecular_function	transcription coactivator activity
F	0004505	molecular_function	phenylalanine 4-monooxygenase activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006558	biological_process	L-phenylalanine metabolic process
F	0006729	biological_process	tetrahydrobiopterin biosynthetic process
F	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
F	0008150	biological_process	biological_process
F	0016829	molecular_function	lyase activity
F	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
F	0042802	molecular_function	identical protein binding
F	0043393	biological_process	regulation of protein binding
F	0045893	biological_process	positive regulation of DNA-templated transcription
G	0003713	molecular_function	transcription coactivator activity
G	0004505	molecular_function	phenylalanine 4-monooxygenase activity
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0006558	biological_process	L-phenylalanine metabolic process
G	0006729	biological_process	tetrahydrobiopterin biosynthetic process
G	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
G	0008150	biological_process	biological_process
G	0016829	molecular_function	lyase activity
G	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
G	0042802	molecular_function	identical protein binding
G	0043393	biological_process	regulation of protein binding
G	0045893	biological_process	positive regulation of DNA-templated transcription
H	0003713	molecular_function	transcription coactivator activity
H	0004505	molecular_function	phenylalanine 4-monooxygenase activity
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0006558	biological_process	L-phenylalanine metabolic process
H	0006729	biological_process	tetrahydrobiopterin biosynthetic process
H	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
H	0008150	biological_process	biological_process
H	0016829	molecular_function	lyase activity
H	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
H	0042802	molecular_function	identical protein binding
H	0043393	biological_process	regulation of protein binding
H	0045893	biological_process	positive regulation of DNA-templated transcription

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING:

Chain	Residue	Details
A	HIS62
E	THR79
F	HIS62
F	THR79
G	HIS62
G	THR79
H	HIS62
H	THR79
A	THR79
B	HIS62
B	THR79
C	HIS62
C	THR79
D	HIS62
D	THR79
E	HIS62

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:8444860

Chain	Residue	Details
A	GLY3
B	GLY3
C	GLY3
D	GLY3
E	GLY3
F	GLY3
G	GLY3
H	GLY3

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
A	LYS59	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
A	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	PRO64	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
A	GLU81	electrostatic stabiliser, hydrogen bond donor
A	CYS82	electrostatic stabiliser, hydrogen bond donor
A	ILE90	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA2
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
B	LYS59	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
B	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
B	PRO64	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
B	GLU81	electrostatic stabiliser, hydrogen bond donor
B	CYS82	electrostatic stabiliser, hydrogen bond donor
B	ILE90	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA3
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
C	LYS59	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
C	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
C	PRO64	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
C	GLU81	electrostatic stabiliser, hydrogen bond donor
C	CYS82	electrostatic stabiliser, hydrogen bond donor
C	ILE90	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA4
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
D	LYS59	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
D	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
D	PRO64	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
D	GLU81	electrostatic stabiliser, hydrogen bond donor
D	CYS82	electrostatic stabiliser, hydrogen bond donor
D	ILE90	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA5
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
E	LYS59	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
E	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
E	PRO64	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
E	GLU81	electrostatic stabiliser, hydrogen bond donor
E	CYS82	electrostatic stabiliser, hydrogen bond donor
E	ILE90	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA6
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
F	LYS59	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
F	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
F	PRO64	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
F	GLU81	electrostatic stabiliser, hydrogen bond donor
F	CYS82	electrostatic stabiliser, hydrogen bond donor
F	ILE90	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA7
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
G	LYS59	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
G	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
G	PRO64	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
G	GLU81	electrostatic stabiliser, hydrogen bond donor
G	CYS82	electrostatic stabiliser, hydrogen bond donor
G	ILE90	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA8
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
H	LYS59	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
H	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
H	PRO64	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
H	GLU81	electrostatic stabiliser, hydrogen bond donor
H	CYS82	electrostatic stabiliser, hydrogen bond donor
H	ILE90	electrostatic stabiliser, hydrogen bond acceptor

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