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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1DCI

DIENOYL-COA ISOMERASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0016853	molecular_function	isomerase activity
B	0003824	molecular_function	catalytic activity
B	0016853	molecular_function	isomerase activity
C	0003824	molecular_function	catalytic activity
C	0016853	molecular_function	isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 A 8

Chain	Residue
A	HOH348
A	HOH358
A	HOH376
A	HOH438
A	HOH462
B	GLY216
B	HOH356
C	GLY216
C	HOH425
A	GLY216
A	HOH336
A	HOH337

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 9

Chain	Residue
A	ARG82
A	ARG86
A	HOH328
A	HOH450
A	HOH528
A	HOH623
A	HOH644
B	ARG73
B	HOH470

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 10

Chain	Residue
B	LYS111
B	HOH458
B	HOH595
C	SER99
C	LYS326

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 11

Chain	Residue
C	LYS308
C	ILE322
C	THR323
C	HOH400
C	HOH500
C	HOH577
C	HOH653
C	HOH657

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 12

Chain	Residue
B	GLN193
B	LYS195
B	HOH417
B	HOH604

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 13

Chain	Residue
C	GLN193
C	LYS195
C	HOH412
C	HOH611

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 14

Chain	Residue
A	GLN193
A	LYS195
A	LYS230
A	HOH432

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 15

Chain	Residue
A	ARG73
A	LYS76
A	HOH641
A	HOH642
B	ARG82
B	HOH644

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 17

Chain	Residue
A	HOH639
A	HOH640
A	HOH641
A	HOH642
A	HOH643
A	HOH644

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MG C 18

Chain	Residue
C	HOH645
C	HOH645
C	HOH646
C	HOH646
C	HOH647
C	HOH647
C	HOH649
C	HOH649

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 19

Chain	Residue
A	HOH645
A	HOH646
B	HOH649
B	HOH650
C	HOH651
C	HOH652

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 20

Chain	Residue
C	HOH653
C	HOH654
C	HOH655
C	HOH656
C	HOH657
C	HOH658

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1

Chain	Residue
A	ILE126
A	ASP204
A	VAL205
A	HOH557
B	LEU301

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 2

Chain	Residue
B	ASP204
B	VAL205
B	HOH400
B	HOH428
C	LEU301

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 3

Chain	Residue
C	HOH495
A	LEU301
C	ILE126
C	ASP204
C	VAL205
C	HOH411

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 4

Chain	Residue
A	ARG218
A	ASN222
B	ASP182
B	LEU278
B	ILE279

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 5

Chain	Residue
B	ARG218
B	ASN222
C	ASP182
C	LEU278
C	ILE279
C	HOH596

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 6

Chain	Residue
A	ASP182
A	LEU278
A	ILE279
C	ARG218
C	ASN222

site_id	CA1
Number of Residues	2
Details	GLU 196 ACCEPTS A PROTON AND ASP 204 DONATES A PROTON DURING CATALYSIS OF THE FORWARD REACTION.

Chain	Residue
A	GLU196
A	ASP204

site_id	CA2
Number of Residues	2
Details	GLU 196 ACCEPTS A PROTON AND ASP 204 DONATES A PROTON DURING CATALYSIS OF THE FORWARD REACTION.

Chain	Residue
B	GLU196
B	ASP204

site_id	CA3
Number of Residues	2
Details	GLU 196 ACCEPTS A PROTON AND ASP 204 DONATES A PROTON DURING CATALYSIS OF THE FORWARD REACTION.

Chain	Residue
C	GLU196
C	ASP204

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 7

Chain	Residue
A	LEU327
C	TRP139
C	TYR140
C	HOH436
C	HOH531

Functional Information from PROSITE/UniProt

site_id	PS00166
Number of Residues	21
Details	ENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. IAaIHGgciGGGvdliSaCDI

Chain	Residue	Details
A	ILE163-ILE183

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P42126

Chain	Residue	Details
A	SER115
A	GLY173
B	SER115
B	GLY173
C	SER115
C	GLY173

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Important for catalytic activity => ECO:0000305\|PubMed:9417087

Chain	Residue	Details
A	GLU196
A	ASP204
B	GLU196
B	ASP204
C	GLU196
C	ASP204

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:O35459

Chain	Residue	Details
A	LYS230
A	LYS316
B	LYS230
B	LYS316
C	LYS230
C	LYS316

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q13011

Chain	Residue	Details
A	SER267
B	SER267
C	SER267

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q13011

Chain	Residue	Details
A	LYS326
B	LYS326
C	LYS326

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 342

Chain	Residue	Details
A	ILE117	transition state stabiliser
A	GLY173	transition state stabiliser
A	ASP176	activator, electrostatic stabiliser, hydrogen bond donor
A	GLU196	hydrogen bond acceptor, polar/non-polar interaction, proton acceptor
A	ASP204	polar/non-polar interaction, proton donor

site_id	MCSA2
Number of Residues	5
Details	M-CSA 342

Chain	Residue	Details
B	ILE117	transition state stabiliser
B	GLY173	transition state stabiliser
B	ASP176	activator, electrostatic stabiliser, hydrogen bond donor
B	GLU196	hydrogen bond acceptor, polar/non-polar interaction, proton acceptor
B	ASP204	polar/non-polar interaction, proton donor

site_id	MCSA3
Number of Residues	5
Details	M-CSA 342

Chain	Residue	Details
C	ILE117	transition state stabiliser
C	GLY173	transition state stabiliser
C	ASP176	activator, electrostatic stabiliser, hydrogen bond donor
C	GLU196	hydrogen bond acceptor, polar/non-polar interaction, proton acceptor
C	ASP204	polar/non-polar interaction, proton donor

218853

PDB entries from 2024-04-24

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