1D2N

D2 DOMAIN OF N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
A	0035494	biological_process	SNARE complex disassembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 99

Chain	Residue
A	ANP1
A	HOH242
A	HOH243
A	HOH244
A	THR558

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site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ANP A 1

Chain	Residue
A	HOH168
A	HOH241
A	HOH243
A	ILE511
A	MET512
A	ASN513
A	GLY514
A	ILE515
A	ILE516
A	TRP518
A	VAL522
A	PRO553
A	HIS554
A	SER555
A	GLY556
A	LYS557
A	THR558
A	ALA559
A	LEU560
A	LYS639
A	SER655
A	LYS716
A	MG99
A	HOH102
A	HOH120
A	HOH160

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 371

Chain	Residue
A	GLU689
A	ASP696
A	THR700
A	THR700

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:9731775, ECO:0000305|PubMed:9727495

Chain	Residue	Details
A	GLY514
A	HIS554

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:9731775

Chain	Residue	Details
A	ALA559

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CDK16 => ECO:0000250|UniProtKB:P46460

Chain	Residue	Details
A	PRO578

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 642

Chain	Residue	Details
A	THR558	electrostatic stabiliser
A	ALA559	electrostatic stabiliser
A	ASP612	electrostatic stabiliser
A	ILE613	proton acceptor
A	LYS640	electrostatic stabiliser
A	LYS717	electrostatic stabiliser

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