1CWR

HUMAN CDC25B CATALYTIC DOMAIN WITHOUT ION IN CATALYTIC SITE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	1902751	biological_process	positive regulation of cell cycle G2/M phase transition

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 567

Chain	Residue
A	ARG488
A	ARG492
A	HOH616
A	HOH644
A	HOH660

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME A 4

Chain	Residue
A	CYS484
A	MET505
A	HOH590
A	HOH613

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE:

Chain	Residue	Details
A	ILE487

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by BRSK1 and MAPK14 => ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:15150265, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	HIS375

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	ILE470
A	LEU563

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