1CR1

CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF THE GENE 4 PROTEIN OF BACTERIOPHAGE T7: COMPLEX WITH DTTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003678	molecular_function	DNA helicase activity
A	0003697	molecular_function	single-stranded DNA binding
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication
A	0043139	molecular_function	5'-3' DNA helicase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 601

Chain	Residue
A	THR293
A	GLY294
A	ILE295
A	ASN296
A	ASP297
A	ARG404
A	LYS408

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 603

Chain	Residue
A	GLN364
A	ARG361
A	ARG363

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site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE TTP A 600

Chain	Residue
A	GLY313
A	SER314
A	GLY315
A	MET316
A	GLY317
A	LYS318
A	SER319
A	THR320
A	HIS465
A	ARG504
A	ARG522
A	PHE523
A	THR524
A	GLY525
A	ASP526
A	TYR535
A	HOH623

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04154

Chain	Residue	Details
A	SER312

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: dTTP/dATP binding => ECO:0000255|HAMAP-Rule:MF_04154, ECO:0000305|PubMed:10892646

Chain	Residue	Details
A	ARG361

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: dTTP/dATP binding => ECO:0000255|HAMAP-Rule:MF_04154, ECO:0000305|PubMed:10535735

Chain	Residue	Details
A	HIS465

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site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: dTTP/dATP binding => ECO:0000255|HAMAP-Rule:MF_04154, ECO:0000305|PubMed:10535735, ECO:0000305|PubMed:10892646

Chain	Residue	Details
A	ARG504
A	ARG522
A	TYR535

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