1C7Q

THE CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE/AUTOCRINE MOTILITY FACTOR/NEUROLEUKIN COMPLEXED WITH ITS CARBOHYDRATE PHOSPHATE INHIBITORS AND ITS SUBSTRATE RECOGNITION MECHANISM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004347	molecular_function	glucose-6-phosphate isomerase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0048029	molecular_function	monosaccharide binding
A	0051156	biological_process	glucose 6-phosphate metabolic process
A	0097367	molecular_function	carbohydrate derivative binding
A	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BE1 A 500

Chain	Residue
A	SER140
A	THR143
A	HIS306
A	GLU417
A	LYS420
A	HOH571

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Functional Information from PROSITE/UniProt

site_id	PS00174
Number of Residues	18
Details	P_GLUCOSE_ISOMERASE_2 Phosphoglucose isomerase signature 2. GhLLgvnpFDQpGVEayK

Chain	Residue	Details
A	GLY403-LYS420

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site_id	PS00765
Number of Residues	14
Details	P_GLUCOSE_ISOMERASE_1 Phosphoglucose isomerase signature 1. DnIGGRYSVlTAVG

Chain	Residue	Details
A	ASP197-GLY210

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00473

Chain	Residue	Details
A	GLU285

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00473

Chain	Residue	Details
A	HIS306
A	LYS420

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	Annotated By Reference To The Literature 1dqr

Chain	Residue	Details
A	GLY201
A	GLU145
A	GLU285
A	LYS139
A	LYS420
A	ARG202

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1dqr

Chain	Residue	Details
A	HIS306

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