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1C5R

STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR

Functional Information from GO Data
ChainGOidnamespacecontents
A0004175molecular_functionendopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0007586biological_processdigestion
A0008236molecular_functionserine-type peptidase activity
A0046872molecular_functionmetal ion binding
A0097180cellular_componentserine protease inhibitor complex
A0097655molecular_functionserpin family protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE FLC A 467
ChainResidue
AHIS57
AASP165
AGLN192
AGLY193
ASER195
AESI246
AHOH366
AHOH532

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 247
ChainResidue
AASN72
AVAL75
AGLU80
AHOH271
AHOH309
AGLU70

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 299
ChainResidue
AARG66
AILE73
AASN74
AVAL75
AVAL90
AHIS91
APRO92
AHOH271
AHOH594

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 333
ChainResidue
AASN97
ATHR98
ALEU99
ASER127
ACYS128
ATRP215

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ESI A 246
ChainResidue
AASP189
ASER190
AGLN192
ASER195
AGLY216
AGLY219
AGLY226
AFLC467

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
ChainResidueDetails
AVAL53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AVAL75
AALA119
AGLY216

site_idSWS_FT_FI2
Number of Residues7
DetailsBINDING:
ChainResidueDetails
ALYS87
AILE89
APRO92
AASN97
AGLN210
AVAL213
AGLY216

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
AHIS57

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
ASER195
AGLY196

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
ASER195
AGLY193

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
ASER195
AHIS57

site_idCSA5
Number of Residues4
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
ASER195
AGLY193
AHIS57

site_idCSA6
Number of Residues4
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
ASER195
AHIS57
AGLY196

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PDB entries from 2024-05-01

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