1BQQ

CRYSTAL STRUCTURE OF THE MT1-MMP--TIMP-2 COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
M	0004222	molecular_function	metalloendopeptidase activity
M	0006508	biological_process	proteolysis
M	0008237	molecular_function	metallopeptidase activity
M	0008270	molecular_function	zinc ion binding
M	0031012	cellular_component	extracellular matrix
T	0002020	molecular_function	protease binding
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0008191	molecular_function	metalloendopeptidase inhibitor activity
T	0009725	biological_process	response to hormone
T	0030414	molecular_function	peptidase inhibitor activity
T	0031012	cellular_component	extracellular matrix
T	0034097	biological_process	response to cytokine
T	0046872	molecular_function	metal ion binding
T	0051045	biological_process	negative regulation of membrane protein ectodomain proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA M 288

Chain	Residue
M	ASP176
M	ASN208
M	GLY210
M	ASP212

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN M 289

Chain	Residue
M	HIS239
M	HIS243
M	HIS249
T	CYS1001

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN M 290

Chain	Residue
M	ASP188
M	HIS201
M	HIS214
M	HIS186

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA M 291

Chain	Residue
M	ASP193
M	GLY194
M	GLY196
M	PHE198
M	ASP216
M	GLU219

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Functional Information from PROSITE/UniProt

site_id	PS00288
Number of Residues	13
Details	TIMP Tissue inhibitors of metalloproteinases signature. CsCsPvHPQqaFC

Chain	Residue	Details
T	CYS1001-CYS1013

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site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAVHELGHAL

Chain	Residue	Details
M	VAL236-LEU245

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:17196980, ECO:0007744|PDB:2E2D

Chain	Residue	Details
T	CYS1001

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Involved in metalloproteinase-binding => ECO:0000269|PubMed:17196980, ECO:0007744|PDB:2E2D

Chain	Residue	Details
T	ASN1038
T	ALA1070
T	ARG1132
T	TRP1151

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