1BOT

CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN ESCHERICHIA COLI GLYCEROL KINASE AND THE ALLOSTERIC REGULATOR FRUCTOSE 1,6-BISPHOSPHATE.

Functional Information from GO Data

Chain	GOid	namespace	contents
O	0004370	molecular_function	glycerol kinase activity
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005829	cellular_component	cytosol
O	0005975	biological_process	carbohydrate metabolic process
O	0006071	biological_process	glycerol metabolic process
O	0006072	biological_process	glycerol-3-phosphate metabolic process
O	0006974	biological_process	DNA damage response
O	0008270	molecular_function	zinc ion binding
O	0016301	molecular_function	kinase activity
O	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
O	0019563	biological_process	glycerol catabolic process
O	0042802	molecular_function	identical protein binding
O	0046872	molecular_function	metal ion binding
Z	0004370	molecular_function	glycerol kinase activity
Z	0005515	molecular_function	protein binding
Z	0005524	molecular_function	ATP binding
Z	0005829	cellular_component	cytosol
Z	0005975	biological_process	carbohydrate metabolic process
Z	0006071	biological_process	glycerol metabolic process
Z	0006072	biological_process	glycerol-3-phosphate metabolic process
Z	0006974	biological_process	DNA damage response
Z	0008270	molecular_function	zinc ion binding
Z	0016301	molecular_function	kinase activity
Z	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
Z	0019563	biological_process	glycerol catabolic process
Z	0042802	molecular_function	identical protein binding
Z	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EPE O 602

Chain	Residue
O	HIS179
O	ASP198
O	TRP199
O	ARG211
O	GLU212
O	LEU214
O	PRO215
O	GLU216
O	VAL217

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL O 601

Chain	Residue
O	ARG83
O	GLU84
O	TRP103
O	TYR135
O	ASP245
O	GLN246
O	PHE270

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL Z 603

Chain	Residue
Z	ARG83
Z	GLU84
Z	TRP103
Z	TYR135
Z	ASP245
Z	GLN246
Z	PHE270

---

Functional Information from PROSITE/UniProt

site_id	PS00445
Number of Residues	21
Details	FGGY_KINASES_2 FGGY family of carbohydrate kinases signature 2. GaIFGLtrgvnan.HIIRATLE

Chain	Residue	Details
O	GLY362-GLU382

---

site_id	PS00933
Number of Residues	13
Details	FGGY_KINASES_1 FGGY family of carbohydrate kinases signature 1. YfSgtKVKWILDH

Chain	Residue	Details
O	TYR135-HIS147

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:8170944, ECO:0007744|PDB:1GLC, ECO:0007744|PDB:1GLD, ECO:0007744|PDB:1GLE

Chain	Residue	Details
O	THR14
O	GLU84
O	THR85
O	PHE136
Z	PHE136
Z	GLN246
Z	ARG479
O	GLN246
O	ARG479
Z	THR14
Z	GLU84
Z	THR85

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:10090737, ECO:0007744|PDB:1BWF, ECO:0007744|PDB:1GLJ, ECO:0007744|PDB:1GLL

Chain	Residue	Details
Z	SER15
Z	ALA412
O	SER15
O	ALA412

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:10090737, ECO:0007744|PDB:1GLJ

Chain	Residue	Details
O	SER16
Z	SER16

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8170944, ECO:0000269|PubMed:8430315, ECO:0000269|PubMed:9817843, ECO:0007744|PDB:1GLB, ECO:0007744|PDB:1GLD, ECO:0007744|PDB:1GLE, ECO:0007744|PDB:1GLF

Chain	Residue	Details
O	ALA18
Z	ALA18

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:9843423, ECO:0007744|PDB:1BO5

Chain	Residue	Details
O	THR235
O	ILE237
Z	THR235
Z	ILE237

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8430315, ECO:0000269|PubMed:9843423, ECO:0007744|PDB:1BO5, ECO:0007744|PDB:1BOT

Chain	Residue	Details
O	GLN247
Z	GLN247

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305|PubMed:10090737, ECO:0007744|PDB:1BWF, ECO:0007744|PDB:1GLL

Chain	Residue	Details
O	GLY268
O	ALA311
O	TRP315
Z	GLY268
Z	ALA311
Z	TRP315

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8170944, ECO:0000269|PubMed:8430315, ECO:0007744|PDB:1GLB, ECO:0007744|PDB:1GLC, ECO:0007744|PDB:1GLD, ECO:0007744|PDB:1GLE

Chain	Residue	Details
O	ASN416
Z	ASN416

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: N6-malonyllysine => ECO:0000269|PubMed:21908771

Chain	Residue	Details
O	GLY233
Z	GLY233

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