1A5C

FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE FROM PLASMODIUM FALCIPARUM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0004332	molecular_function	fructose-bisphosphate aldolase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006096	biological_process	glycolytic process
A	0016020	cellular_component	membrane
A	0016829	molecular_function	lyase activity
A	0020002	cellular_component	host cell plasma membrane
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
B	0003779	molecular_function	actin binding
B	0004332	molecular_function	fructose-bisphosphate aldolase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006096	biological_process	glycolytic process
B	0016020	cellular_component	membrane
B	0016829	molecular_function	lyase activity
B	0020002	cellular_component	host cell plasma membrane
B	0030388	biological_process	fructose 1,6-bisphosphate metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00158
Number of Residues	11
Details	ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VlLEGaLLKPN

Chain	Residue	Details
A	VAL228-ASN238

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P00883

Chain	Residue	Details
A	GLU194
B	GLU194

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Schiff-base intermediate with dihydroxyacetone-P => ECO:0000250|UniProtKB:P00883

Chain	Residue	Details
A	LYS236
B	LYS236

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00883

Chain	Residue	Details
A	ARG61
A	LYS151
B	ARG61
B	LYS151

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate => ECO:0000250|UniProtKB:P00883

Chain	Residue	Details
A	TYR368
B	TYR368

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