登録情報 | データベース: PDB / ID: 2kkf |
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タイトル | Solution structure of MLL CXXC domain in complex with palindromic CPG DNA |
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要素 | - 5'-D(*CP*CP*CP*TP*GP*CP*GP*CP*AP*GP*GP*G)-3'
- Histone-lysine N-methyltransferase HRX
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キーワード | DNA BINDING PROTEIN/DNA / PROTEIN-DNA COMPLEX (デオキシリボ核酸) / CXXC DOMAIN / MLL / CPG DNA / CHROMOSOMAL REARRANGEMENT / DNA-BINDING / METAL-BINDING / NUCLEUS (細胞核) / ZINC-FINGER (ジンクフィンガー) / DNA BINDING PROTEIN-DNA COMPLEX / Alternative splicing (選択的スプライシング) / Apoptosis (アポトーシス) / Bromodomain (ブロモドメイン) / Chromatin regulator / Isopeptide bond / Methyltransferase (メチルトランスフェラーゼ) / Phosphoprotein / Polymorphism / Proto-oncogene (がん遺伝子) / S-adenosyl-L-methionine (S-アデノシルメチオニン) / Transcription (転写 (生物学)) / Transcription regulation / Transferase (転移酵素) / Ubl conjugation / Zinc (亜鉛) |
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機能・相同性 | 機能・相同性情報
protein-cysteine methyltransferase activity / response to potassium ion / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / unmethylated CpG binding / histone H3K4 trimethyltransferase activity / negative regulation of DNA methylation-dependent heterochromatin formation / regulation of short-term neuronal synaptic plasticity / definitive hemopoiesis / histone H3K4 methyltransferase activity ...protein-cysteine methyltransferase activity / response to potassium ion / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / unmethylated CpG binding / histone H3K4 trimethyltransferase activity / negative regulation of DNA methylation-dependent heterochromatin formation / regulation of short-term neuronal synaptic plasticity / definitive hemopoiesis / histone H3K4 methyltransferase activity / T-helper 2 cell differentiation / embryonic hemopoiesis / exploration behavior / anterior/posterior pattern specification / histone methyltransferase complex / : / Formation of WDR5-containing histone-modifying complexes / minor groove of adenine-thymine-rich DNA binding / 脱分極 / MLL1 complex / negative regulation of fibroblast proliferation / homeostasis of number of cells within a tissue / spleen development / transcription initiation-coupled chromatin remodeling / cellular response to transforming growth factor beta stimulus / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / post-embryonic development / circadian regulation of gene expression / protein modification process / lysine-acetylated histone binding / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / visual learning / PKMTs methylate histone lysines / Transcriptional regulation of granulopoiesis / RUNX1 regulates transcription of genes involved in differentiation of HSCs / fibroblast proliferation / protein-containing complex assembly / apoptotic process / chromatin binding / positive regulation of DNA-templated transcription / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / zinc ion binding / 核質 / identical protein binding / 細胞核 / 細胞質基質類似検索 - 分子機能 KMT2A, ePHD domain / KMT2A, PHD domain 1 / KMT2A, PHD domain 2 / KMT2A, PHD domain 3 / Methyltransferase, trithorax / : / FY-rich, N-terminal / F/Y-rich N-terminus / PHD-like zinc-binding domain / FYR domain FYRN motif profile. ...KMT2A, ePHD domain / KMT2A, PHD domain 1 / KMT2A, PHD domain 2 / KMT2A, PHD domain 3 / Methyltransferase, trithorax / : / FY-rich, N-terminal / F/Y-rich N-terminus / PHD-like zinc-binding domain / FYR domain FYRN motif profile. / "FY-rich" domain, N-terminal region / FY-rich, C-terminal / F/Y rich C-terminus / FYR domain FYRC motif profile. / "FY-rich" domain, C-terminal region / CXXC zinc finger domain / Zinc finger, CXXC-type / Zinc finger CXXC-type profile. / Cysteine-rich motif following a subset of SET domains / Post-SET domain / Post-SET domain profile. / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. / PHD-finger / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger, FYVE/PHD-type / Bromodomain profile. / bromo domain / ブロモドメイン / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type類似検索 - ドメイン・相同性 デオキシリボ核酸 / DNA (> 10) / Histone-lysine N-methyltransferase 2A類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / SIMULATED ANNEALING, DISTANCE GEOMETRY |
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Model details | lowest energy, model 1 |
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データ登録者 | Cierpicki, T. / Riesbeck, J.E. / Grembecka, J.E. / Lukasik, S.M. / Popovic, R. / Omonkowska, M. / Shultis, D.S. / Zeleznik-Le, N.J. / Bushweller, J.H. |
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引用 | ジャーナル: Nat.Struct.Mol.Biol. / 年: 2010 タイトル: Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia. 著者: Cierpicki, T. / Risner, L.E. / Grembecka, J. / Lukasik, S.M. / Popovic, R. / Omonkowska, M. / Shultis, D.D. / Zeleznik-Le, N.J. / Bushweller, J.H. |
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履歴 | 登録 | 2009年6月18日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2009年12月8日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2022年3月16日 | Group: Data collection / Database references / Derived calculations カテゴリ: database_2 / pdbx_nmr_software ...database_2 / pdbx_nmr_software / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _struct_ref_seq.db_align_beg / _struct_ref_seq.db_align_end / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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