2MXQ
| The solution structure of DEFA1, a highly potent antimicrobial peptide from the horse | Descriptor: | Paneth cell-specific alpha-defensin 1 | Authors: | Jung, S, Michalek, M, Shomali, M, Soennichsen, F.D. | Deposit date: | 2015-01-12 | Release date: | 2015-04-22 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution structure and functional studies of the highly potent equine antimicrobial peptide DEFA1. Biochem.Biophys.Res.Commun., 459, 2015
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6SBO
| Estrogen receptor mutant L536S | Descriptor: | 6-(2,4-dichlorophenyl)-5-[4-[(3~{S})-1-(3-fluoranylpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7~{H}-benzo[7]annulene-2-carboxylic acid, Estrogen receptor | Authors: | Vallee, F, Steier, V, Rak, A. | Deposit date: | 2019-07-22 | Release date: | 2019-11-27 | Last modified: | 2020-02-05 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer. J.Med.Chem., 63, 2020
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