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1SRS
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BU of 1srs by Molmil
SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA
Descriptor: DNA (5'-D(*CP*CP*(5IU)P*TP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*CP*CP*AP*TP*G)-3'), DNA (5'-D(*CP*CP*AP*TP*GP*GP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*A P*AP*G)-3'), PROTEIN (SERUM RESPONSE FACTOR (SRF))
Authors:Pellegrini, L, Tan, S, Richmond, T.J.
Deposit date:1995-07-28
Release date:1995-07-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of serum response factor core bound to DNA.
Nature, 376, 1995
1E0O
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BU of 1e0o by Molmil
CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, FIBROBLAST GROWTH FACTOR 1, FIBROBLAST GROWTH FACTOR RECEPTOR 2, ...
Authors:Pellegrini, L, Burke, D.F, von Delft, F, Mulloy, B, Blundell, T.L.
Deposit date:2000-04-03
Release date:2000-10-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin
Nature, 407, 2000
1N0W
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BU of 1n0w by Molmil
Crystal structure of a RAD51-BRCA2 BRC repeat complex
Descriptor: 1,2-ETHANEDIOL, ARTIFICIAL GLY-SER-MSE-GLY PEPTIDE, Breast cancer type 2 susceptibility protein, ...
Authors:Pellegrini, L, Yu, D.S, Lo, T, Anand, S, Lee, M, Blundell, T.L, Venkitaraman, A.R.
Deposit date:2002-10-15
Release date:2002-11-27
Last modified:2020-01-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
Nature, 420, 2002
2ILR
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BU of 2ilr by Molmil
Crystal structure of human Fanconi Anemia protein E C-terminal domain
Descriptor: Fanconi anemia group E protein
Authors:Pellegrini, L, Nookala, R.K.
Deposit date:2006-10-03
Release date:2007-02-27
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into Fanconi Anaemia from the structure of human FANCE
Nucleic Acids Res., 35, 2007
6T9Q
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BU of 6t9q by Molmil
Crystal structure of the second, C-terminal repeat of the DNA-binding domain of human TImeless
Descriptor: Protein timeless homolog
Authors:Pellegrini, L, Holzer, S.
Deposit date:2019-10-28
Release date:2020-07-01
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
Embo J., 39, 2020
5NWL
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BU of 5nwl by Molmil
Crystal structure of a human RAD51-ATP filament.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA repair protein RAD51 homolog 1, MAGNESIUM ION
Authors:Pellegrini, L, Moschetti, T.
Deposit date:2017-05-06
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.93 Å)
Cite:Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA.
EMBO J., 37, 2018
5OFN
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BU of 5ofn by Molmil
Crystal structure of the heterotrimeric PriSLX primase from S. solfataricus.
Descriptor: DNA primase large subunit PriL,PriL-X fusion protein, DNA primase small subunit PriS, ZINC ION
Authors:Pellegrini, L, Holzer, S.
Deposit date:2017-07-11
Release date:2017-11-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster.
Nat Commun, 8, 2017
5OF3
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BU of 5of3 by Molmil
Crystal structure of the heterotrimeric PriSLX primase from S. solfataricus.
Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA primase large subunit PriL, DNA primase small subunit PriS, ...
Authors:Pellegrini, L, Holzer, S.
Deposit date:2017-07-10
Release date:2017-11-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.906 Å)
Cite:Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster.
Nat Commun, 8, 2017
5OGS
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BU of 5ogs by Molmil
Crystal structure of human AND-1 SepB domain
Descriptor: MALONATE ION, WD repeat and HMG-box DNA-binding protein 1
Authors:Pellegrini, L, Simon, A.C.
Deposit date:2017-07-13
Release date:2017-11-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:The human CTF4-orthologue AND-1 interacts with DNA polymerase alpha /primase via its unique C-terminal HMG box.
Open Biol, 7, 2017
4D2H
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BU of 4d2h by Molmil
Crystal structure of the tetramerisation domain of human CtIP
Descriptor: RBBP8, SULFATE ION
Authors:Davies, O.R, Sun, M, Pellegrini, L.
Deposit date:2014-05-09
Release date:2015-01-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ctip Tetramer Assembly is Required for DNA-End Resection and Repair.
Nat.Struct.Mol.Biol., 22, 2015
3LGB
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BU of 3lgb by Molmil
Crystal Structure of the Fe-S Domain of the yeast DNA primase
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA primase large subunit, GLYCEROL, ...
Authors:Sauguet, L, Pellegrini, L.
Deposit date:2010-01-20
Release date:2010-04-21
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Shared Active Site Architecture between the Large Subunit of Eukaryotic Primase and DNA Photolyase
PLOS ONE, 5, 2010
5HOG
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BU of 5hog by Molmil
Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Dna2.
Descriptor: DNA polymerase alpha-binding protein, Dna2p
Authors:Simon, A.C, Pellegrini, L.
Deposit date:2016-01-19
Release date:2016-06-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.092 Å)
Cite:Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase.
Mol.Cell, 63, 2016
5HOI
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BU of 5hoi by Molmil
Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Tof2.
Descriptor: DNA polymerase alpha-binding protein, Topoisomerase 1-associated factor 2
Authors:Simon, A.C, Pellegrini, L.
Deposit date:2016-01-19
Release date:2016-06-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase.
Mol.Cell, 63, 2016
4WWM
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BU of 4wwm by Molmil
X-ray crystal structure of Sulfolobus solfataricus Urm1
Descriptor: SULFATE ION, Uncharacterized protein
Authors:Bray, S.M, Anjum, S.R, Blackwood, J.K, Kilkenny, M.L, Coelho, M.A, Foster, B.M, Pellegrini, L, Robinson, N.P.
Deposit date:2014-11-11
Release date:2015-09-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Involvement of a eukaryotic-like ubiquitin-related modifier in the proteasome pathway of the archaeon Sulfolobus acidocaldarius.
Nat Commun, 6, 2015
7OPL
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BU of 7opl by Molmil
CryoEM structure of DNA Polymerase alpha - primase bound to SARS CoV nsp1
Descriptor: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ...
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2021-06-01
Release date:2021-11-10
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.12 Å)
Cite:Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase alpha-primase.
Protein Sci., 31, 2022
7BGF
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BU of 7bgf by Molmil
CRYSTAL STRUCTURE OF THE N-TERMINAL DIMERIC COILED COIL OF THE HUMAN CTIP PROTEIN
Descriptor: DNA endonuclease RBBP8,CtIP/RBBP8
Authors:Morton, C.R, Pellegrini, L.
Deposit date:2021-01-07
Release date:2021-06-30
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structural basis for the coiled-coil architecture of human CtIP.
Open Biology, 11, 2021
1IK9
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BU of 1ik9 by Molmil
CRYSTAL STRUCTURE OF A XRCC4-DNA LIGASE IV COMPLEX
Descriptor: DNA LIGASE IV, DNA REPAIR PROTEIN XRCC4
Authors:Sibanda, B.L, Critchlow, S.E, Begun, J, Pei, X.Y, Jackson, S.P, Blundell, T.L, Pellegrini, L.
Deposit date:2001-05-03
Release date:2001-11-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of an Xrcc4-DNA ligase IV complex.
Nat.Struct.Biol., 8, 2001
8RCD
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BU of 8rcd by Molmil
RAD51 nucleoprotein filament on abasic single-stranded DNA
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*GP*GP*(3DR)P*AP*TP*(3DR)P*CP*AP*(3DR)P*TP*GP*(3DR)P*TP*AP*(3DR)P*AP*CP*(3DR)P*TP*GP*(3DR)P*GP*C)-3'), ...
Authors:Appleby, R, Pellegrini, L.
Deposit date:2023-12-06
Release date:2024-09-04
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:RAD51 protects abasic sites to prevent replication fork breakage.
Mol.Cell, 84, 2024
8RCF
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BU of 8rcf by Molmil
RAD51 nucleoprotein filament on double-stranded abasic DNA
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*CP*AP*CP*CP*AP*CP*CP*AP*CP*CP*AP*CP*CP*AP*CP*CP*AP*CP*CP*AP*CP*CP*A)-3'), ...
Authors:Appleby, R, Pellegrini, L.
Deposit date:2023-12-06
Release date:2024-09-04
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:RAD51 protects abasic sites to prevent replication fork breakage.
Mol.Cell, 84, 2024
3FLO
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BU of 3flo by Molmil
Crystal structure of the carboxyl-terminal domain of yeast DNA polymerase alpha in complex with its B subunit
Descriptor: DNA polymerase alpha catalytic subunit A, DNA polymerase alpha subunit B, SULFATE ION, ...
Authors:Klinge, S.N, Pellegrini, L.
Deposit date:2008-12-19
Release date:2009-06-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:3D architecture of DNA Pol alpha reveals the functional core of multi-subunit replicative polymerases
Embo J., 28, 2009
5NXQ
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BU of 5nxq by Molmil
Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to a stapled Sld5 CIP
Descriptor: DNA polymerase alpha-binding protein, GLYCEROL, MET-ASP-ILE-UA1-ILE-ASP-ASP-ILE-LEU-UA2-GLU-LEU-ASP-LYS-GLU
Authors:Wu, Y, Pellegrini, L.
Deposit date:2017-05-10
Release date:2017-08-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.413 Å)
Cite:Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.
Angew. Chem. Int. Ed. Engl., 56, 2017
8BSC
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BU of 8bsc by Molmil
CryoEM structure of the RAD51 nucleoprotein filament in the presence of ADP and Ca2+
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, DNA repair protein RAD51 homolog 1
Authors:Appleby, R, Bollschweiler, D, Pellegrini, L.
Deposit date:2022-11-24
Release date:2023-05-03
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A metal ion-dependent mechanism of RAD51 nucleoprotein filament disassembly.
Iscience, 26, 2023
8BQ2
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BU of 8bq2 by Molmil
CryoEM structure of the pre-synaptic RAD51 nucleoprotein filament in the presence of ATP and Ca2+
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ...
Authors:Appleby, R, Bollschweiler, D, Pellegrini, L.
Deposit date:2022-11-18
Release date:2023-05-03
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:A metal ion-dependent mechanism of RAD51 nucleoprotein filament disassembly.
Iscience, 26, 2023
8BR2
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BU of 8br2 by Molmil
CryoEM structure of the post-synaptic RAD51 nucleoprotein filament in the presence of ATP and Ca2+
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*GP*CP*GP*AP*GP*CP*TP*CP*GP*AP*TP*GP*CP*AP*CP*CP*TP*CP*CP*A)-3'), ...
Authors:Appleby, R, Bollschweiler, D, Pellegrini, L.
Deposit date:2022-11-22
Release date:2023-05-03
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:A metal ion-dependent mechanism of RAD51 nucleoprotein filament disassembly.
Iscience, 26, 2023
2YGK
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BU of 2ygk by Molmil
Crystal structure of the NurA nuclease from Sulfolobus solfataricus
Descriptor: MANGANESE (II) ION, NURA
Authors:Rzechorzek, N.J, Blackwood, J.K, Abrams, A.S, Maman, J.D, Robinson, N.P, Pellegrini, L.
Deposit date:2011-04-18
Release date:2011-12-14
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Insights Into DNA-End Processing by the Archaeal Hera Helicase-Nura Nuclease Complex.
Nucleic Acids Res., 40, 2012

 

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