6W4Z
| Galectin-8N terminal domain in complex with Methyl 3-O-[3-O-benzyloxy]-malonyl-beta-D-galactopyranoside | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Galectin-8, ... | Authors: | Patel, B, Kishor, C, Blanchard, H. | Deposit date: | 2020-03-12 | Release date: | 2020-09-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Rational Design and Synthesis of Methyl-beta-d-galactomalonyl Phenyl Esters as Potent Galectin-8 N Antagonists. J.Med.Chem., 63, 2020
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1ZX9
| Crystal Structure of Tn501 MerA | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Mercuric reductase | Authors: | Dong, A, Ledwidge, R, Patel, B, Fiedler, D, Falkowski, M, Zelikova, J, Summers, A.O, Pai, E.F, Miller, S.M. | Deposit date: | 2005-06-07 | Release date: | 2005-07-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | NmerA, the Metal Binding Domain of Mercuric Ion Reductase, Removes Hg(2+) from Proteins, Delivers It to the Catalytic Core, and Protects Cells under Glutathione-Depleted Conditions Biochemistry, 44, 2005
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2B0H
| Solution structure of VBS3 fragment of talin | Descriptor: | Talin-1 | Authors: | Gingras, A.R, Vogel, K.P, Steinhoff, H.J, Ziegler, W.H, Patel, B, Emsley, J, Critchley, D.R, Roberts, G.C, Barsukov, I.L. | Deposit date: | 2005-09-14 | Release date: | 2006-01-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural and Dynamic Characterization of a Vinculin Binding Site in the Talin Rod Biochemistry, 45, 2006
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1ZK7
| Crystal Structure of Tn501 MerA | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Mercuric reductase, ... | Authors: | Dong, A, Ledwidge, R, Patel, B, Fiedler, D, Falkowski, M, Zelikova, J, Summers, A.O, Pai, E.F, Miller, S.M. | Deposit date: | 2005-05-02 | Release date: | 2005-07-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | NmerA, the Metal Binding Domain of Mercuric Ion Reductase, Removes Hg(2+) from Proteins, Delivers It to the Catalytic Core, and Protects Cells under Glutathione-Depleted Conditions Biochemistry, 44, 2005
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1U89
| Solution structure of VBS2 fragment of talin | Descriptor: | Talin 1 | Authors: | Fillingham, I, Gingras, A.R, Papagrigoriou, E, Patel, B, Emsley, J, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. | Deposit date: | 2004-08-05 | Release date: | 2005-01-18 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head. Structure, 13, 2005
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1U6H
| Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879) | Descriptor: | Talin, Vinculin | Authors: | Fillingham, I, Gingras, A.R, Papagrigoriou, E, Patel, B, Emsley, J, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. | Deposit date: | 2004-07-30 | Release date: | 2005-01-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head. Structure, 13, 2005
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2KC1
| NMR structure of the F0 domain (residues 0-85) of the talin ferm domain | Descriptor: | MKIAA1027 protein | Authors: | Goult, B.T, Elliott, P.R, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. | Deposit date: | 2008-12-13 | Release date: | 2010-01-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. Embo J., 29, 2010
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2KMA
| NMR structure of the F0F1 double domain (residues 1-202) of the talin ferm domain | Descriptor: | Talin 1 | Authors: | Goult, B.T, Elliott, P.R, Bate, N, Roberts, G.C, Critchley, D.R, Barsukov, I.L. | Deposit date: | 2009-07-25 | Release date: | 2010-03-02 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. Embo J., 2010
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2KT2
| Structure of NmerA, the N-terminal HMA domain of Tn501 Mercuric Reductase | Descriptor: | Mercuric reductase | Authors: | Ledwidge, R, Danacea, F, Dotsch, V, Miller, S.M. | Deposit date: | 2010-01-17 | Release date: | 2010-09-22 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | NmerA of Tn501 mercuric ion reductase: structural modulation of the pKa values of the metal binding cysteine thiols. Biochemistry, 49, 2010
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2KT3
| Structure of Hg-NmerA, Hg(II) complex of the N-terminal domain of Tn501 Mercuric Reductase | Descriptor: | MERCURY (II) ION, Mercuric reductase | Authors: | Miller, S.M, Ledwidge, R, Danacea, F, Dotsch, V. | Deposit date: | 2010-01-17 | Release date: | 2010-09-22 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | NmerA of Tn501 mercuric ion reductase: structural modulation of the pKa values of the metal binding cysteine thiols. Biochemistry, 49, 2010
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3ZH8
| A novel small molecule aPKC inhibitor | Descriptor: | (2S)-3-phenyl-N~1~-[2-(pyridin-4-yl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl]propane-1,2-diamine, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Kjaer, S, Purkiss, A.G, Kostelecky, B, Knowles, P.P, Soriano, E, Murray-Rust, J, McDonald, N.Q. | Deposit date: | 2012-12-20 | Release date: | 2013-02-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.739 Å) | Cite: | Adenosine-Binding Motif Mimicry and Cellular Effects of a Thieno[2,3-D]Pyrimidine-Based Chemical Inhibitor of Atypical Protein Kinase C Isozymes. Biochem.J., 451, 2013
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7UFV
| Crystal structure of the WDR domain of human DCAF1 in complex with OICR-6766 | Descriptor: | (3P)-N-[(1S)-3-amino-1-(3-chlorophenyl)-3-oxopropyl]-3-(2-fluorophenyl)-1H-pyrazole-4-carboxamide, DDB1- and CUL4-associated factor 1, UNKNOWN ATOM OR ION | Authors: | Kimani, S, Li, A, Li, Y, Dong, A, Hutchinson, A, Seitova, A, Wilson, B, Al-Awar, R, Vedadi, M, Brown, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | Deposit date: | 2022-03-23 | Release date: | 2022-05-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of Nanomolar DCAF1 Small Molecule Ligands. J.Med.Chem., 66, 2023
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1XWJ
| Vinculin head (1-258) in complex with the talin vinculin binding site 3 (1945-1969) | Descriptor: | Talin, Vinculin | Authors: | Gingras, A.R, Papagrigoriou, E, Barsukov, I.L, Critchley, D.R, Emsley, J. | Deposit date: | 2004-11-01 | Release date: | 2005-10-11 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and Dynamic Characterization of a Vinculin Binding Site in the Talin Rod Biochemistry, 45, 2006
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1T01
| Vinculin complexed with the VBS1 helix from talin | Descriptor: | Talin 1, unnamed protein product | Authors: | Papagrigoriou, E, Gingras, A.R, Barsukov, I.L, Critchley, D.R, Emsley, J. | Deposit date: | 2004-04-07 | Release date: | 2004-08-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle Embo J., 23, 2004
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1SJ7
| Crystal Structure of Talin Rod 482-655 | Descriptor: | PLATINUM (II) ION, Talin 1 | Authors: | Papagrigoriou, E, Gingras, A.R, Barsukov, I.L, Critchley, D.R, Emsley, J. | Deposit date: | 2004-03-03 | Release date: | 2004-08-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle EMBO J., 23, 2004
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1SJ8
| Solution Structure of the R1R2 Domains of Talin | Descriptor: | Talin 1 | Authors: | Papagrigoriou, E, Gingras, A.R, Barsukov, I.L, Critchley, D.R, Emsley, J. | Deposit date: | 2004-03-03 | Release date: | 2004-08-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle EMBO J., 23, 2004
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2KBB
| Solution Structure of the R9 Domain of Talin | Descriptor: | Talin-1 | Authors: | Goult, B.T, Gingras, A.R, Bate, N, Critchley, D.R, Barsukov, I.L. | Deposit date: | 2008-11-24 | Release date: | 2009-03-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The structure of an interdomain complex that regulates talin activity. J.Biol.Chem., 284, 2009
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2KC2
| NMR structure of the F1 domain (residues 86-202) of the talin | Descriptor: | Talin-1 | Authors: | Goult, B.T, Elliott, P.R, Roberts, G.C.K, Critchely, D.R, Barsukov, I.L. | Deposit date: | 2008-12-13 | Release date: | 2010-01-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. Embo J., 29, 2010
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2KGX
| HADDOCK structure of the talin F3 domain in complex with talin 1655-1822 | Descriptor: | MKIAA1027 protein, Talin-1 | Authors: | Goult, B.T, Gingras, A.R, Bate, N, Critchley, D.R, Barsukov, I.L. | Deposit date: | 2009-03-23 | Release date: | 2009-03-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The structure of an interdomain complex that regulates talin activity. J.Biol.Chem., 284, 2009
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2KMC
| Solution Structure of the N-terminal domain of kindlin-1 | Descriptor: | Fermitin family homolog 1 | Authors: | Goult, B.T, Bate, N, Roberts, G.C, Barsukov, I.L, Critchley, D.R. | Deposit date: | 2009-07-27 | Release date: | 2009-10-06 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The Structure of the N-Terminus of Kindlin-1: A Domain Important for alphaIIbbeta3 Integrin Activation J.Mol.Biol., 394, 2009
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2X0C
| Crystal Structure of the R7R8 domains of Talin | Descriptor: | TALIN-1 | Authors: | Gingras, A.R, Goult, B.T, Bate, N, Barsukov, I.L, Emsley, J, Critchely, D.R. | Deposit date: | 2009-12-08 | Release date: | 2010-07-07 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Central Region of Talin Has a Unique Fold that Binds Vinculin and Actin. J.Biol.Chem., 285, 2010
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3DYJ
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