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3ZH8

A novel small molecule aPKC inhibitor

Summary for 3ZH8
Entry DOI10.2210/pdb3zh8/pdb
DescriptorPROTEIN KINASE C IOTA TYPE, IODIDE ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywordstransferase, agc kinases, cell polarity, cell migration
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains3
Total formula weight124448.51
Authors
Kjaer, S.,Purkiss, A.G.,Kostelecky, B.,Knowles, P.P.,Soriano, E.,Murray-Rust, J.,McDonald, N.Q. (deposition date: 2012-12-20, release date: 2013-02-27, Last modification date: 2023-12-20)
Primary citationKjaer, S.,Linch, M.,Purkiss, A.,Kostelecky, B.,Knowles, P.P.,Rosse, C.,Riou, P.,Soudy, C.,Kaye, S.,Patel, B.,Soriano, E.,Murray-Rust, J.,Barton, C.,Dillon, C.,Roffey, J.,Parker, P.J.,Mcdonald, N.Q.
Adenosine-Binding Motif Mimicry and Cellular Effects of a Thieno[2,3-D]Pyrimidine-Based Chemical Inhibitor of Atypical Protein Kinase C Isozymes.
Biochem.J., 451:329-, 2013
Cited by
PubMed: 23418854
DOI: 10.1042/BJ20121871
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.739 Å)
Structure validation

217705

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