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4WA6
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BU of 4wa6 by Molmil
Structure of yeast SAGA DUBm with Sgf73 N59D mutant at 2.36 angstroms resolution
Descriptor: SAGA-associated factor 11, SAGA-associated factor 73, Transcription and mRNA export factor SUS1, ...
Authors:Wolberger, C, Yan, M.
Deposit date:2014-08-28
Release date:2015-03-04
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structure of yeast SAGA DUBm with Sgf73 N59D mutant at 2.36 angstroms resolution
To Be Published
1APL
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BU of 1apl by Molmil
CRYSTAL STRUCTURE OF A MAT-ALPHA2 HOMEODOMAIN-OPERATOR COMPLEX SUGGESTS A GENERAL MODEL FOR HOMEODOMAIN-DNA INTERACTIONS
Descriptor: DNA (5'-D(*AP*CP*AP*TP*GP*TP*AP*AP*TP*TP*CP*AP*TP*TP*TP*AP*C P*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*GP*TP*AP*AP*AP*TP*GP*AP*AP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MAT-ALPHA2 HOMEODOMAIN)
Authors:Wolberger, C, Vershon, A.K, Liu, B, Johnson, A.D, Pabo, C.O.
Deposit date:1993-10-04
Release date:1993-10-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions.
Cell(Cambridge,Mass.), 67, 1991
3PDH
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BU of 3pdh by Molmil
Structure of Sir2Tm bound to a propionylated peptide
Descriptor: Cellular tumor antigen p53 18-residue peptide, NAD-dependent deacetylase, ZINC ION
Authors:Wolberger, C, Bheda, P.
Deposit date:2010-10-22
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Sir2Tm bound to a propionylated peptide.
Protein Sci., 20, 2011
4W4U
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BU of 4w4u by Molmil
Structure of yeast SAGA DUBm with Sgf73 Y57A mutant at 2.8 angstroms resolution
Descriptor: SAGA-associated factor 11, SAGA-associated factor 73, Transcription and mRNA export factor SUS1, ...
Authors:Wolberger, C, Yan, M.
Deposit date:2014-08-15
Release date:2015-07-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity.
J.Mol.Biol., 427, 2015
5H84
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BU of 5h84 by Molmil
Human Gcn5 bound to propionyl-CoA
Descriptor: 1,2-ETHANEDIOL, Histone acetyltransferase KAT2A, ISOPROPYL ALCOHOL, ...
Authors:Wolberger, C, Ringel, A.E.
Deposit date:2015-12-23
Release date:2016-03-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for acyl-group discrimination by human Gcn5L2.
Acta Crystallogr D Struct Biol, 72, 2016
5H86
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BU of 5h86 by Molmil
Human Gcn5 bound to butyryl-CoA
Descriptor: 1,2-ETHANEDIOL, Butyryl Coenzyme A, Histone acetyltransferase KAT2A
Authors:Wolberger, C, Ringel, A.E.
Deposit date:2015-12-23
Release date:2016-03-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural basis for acyl-group discrimination by human Gcn5L2.
Acta Crystallogr D Struct Biol, 72, 2016
2GMI
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BU of 2gmi by Molmil
Mms2/Ubc13~Ubiquitin
Descriptor: Ubiquitin, Ubiquitin-conjugating enzyme E2 13, Ubiquitin-conjugating enzyme variant MMS2
Authors:Wolberger, C, Eddins, M.J, Carlile, C.M, Gomez, K.G, Pickart, C.M.
Deposit date:2006-04-06
Release date:2006-09-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation.
Nat.Struct.Mol.Biol., 13, 2006
8DU4
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BU of 8du4 by Molmil
Complex between RbBP5-WDR5 and an H2B-ubiquitinated nucleosome
Descriptor: 601 DNA (146-MER), Histone H2A, Histone H2B 1.1, ...
Authors:Niklas, H.A, Rahman, S, Worden, E.J, Wolberger, C.
Deposit date:2022-07-26
Release date:2022-09-21
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome.
Proc.Natl.Acad.Sci.USA, 119, 2022
1AKH
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BU of 1akh by Molmil
MAT A1/ALPHA2/DNA TERNARY COMPLEX
Descriptor: DNA (5'-D(*TP*AP*CP*AP*TP*GP*TP*AP*AP*AP*AP*AP*TP*TP*TP*AP*C P*AP*TP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*GP*AP*TP*GP*TP*AP*AP*AP*TP*TP*TP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MATING-TYPE PROTEIN A-1), ...
Authors:Li, T, Jin, Y, Vershon, A.K, Wolberger, C.
Deposit date:1997-05-19
Release date:1998-05-20
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the MATa1/MATalpha2 homeodomain heterodimer in complex with DNA containing an A-tract.
Nucleic Acids Res., 26, 1998
7UD5
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BU of 7ud5 by Molmil
Complex between MLL1-WRAD and an H2B-ubiquitinated nucleosome
Descriptor: 601 DNA (146-MER), Histone H2A, Histone H2B 1.1, ...
Authors:Niklas, H.A, Rahman, S, Worden, E.J, Wolberger, C.
Deposit date:2022-03-18
Release date:2022-09-21
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome.
Proc.Natl.Acad.Sci.USA, 119, 2022
6VEN
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BU of 6ven by Molmil
Yeast COMPASS in complex with a ubiquitinated nucleosome
Descriptor: 601 DNA (146-MER), COMPASS component BRE2, COMPASS component SDC1, ...
Authors:Worden, E.J, Wolberger, C.
Deposit date:2020-01-02
Release date:2020-01-15
Last modified:2020-01-22
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome.
Elife, 9, 2020
4TWI
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BU of 4twi by Molmil
The structure of Sir2Af1 bound to a succinylated histone peptide
Descriptor: GLYCEROL, NAD-dependent protein deacylase 1, Succinylated H4 Peptide (aa8-20), ...
Authors:Ringel, A.E, Roman, C, Wolberger, C.
Deposit date:2014-06-30
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.
Protein Sci., 23, 2014
4TWJ
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BU of 4twj by Molmil
The structure of Sir2Af2 bound to a myristoylated histone peptide
Descriptor: ACETATE ION, GLYCEROL, Histone H4 peptide, ...
Authors:Ringel, A.E, Roman, C, Wolberger, C.
Deposit date:2014-06-30
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.
Protein Sci., 23, 2014
6AQR
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BU of 6aqr by Molmil
SAGA DUB module Ubp8(C146A)/Sgf11/Sus1/Sgf73 bound to monoubiquitin
Descriptor: Polyubiquitin-C, SAGA-associated factor 11, SAGA-associated factor 73, ...
Authors:Morrow, M.E, Morgan, M.T, Wolberger, C.
Deposit date:2017-08-21
Release date:2018-07-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.
EMBO Rep., 19, 2018
4LDT
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BU of 4ldt by Molmil
The structure of h/ceOTUB1-ubiquitin aldehyde-UBCH5B~Ub
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, Ubiquitin, ...
Authors:Wiener, R, DiBello, A.T, Lombardi, P.M, Guzzo, C.M, Zhang, X, Matunis, M.J, Wolberger, C.
Deposit date:2013-06-25
Release date:2013-08-14
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.
Nat.Struct.Mol.Biol., 20, 2013
4ZUX
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BU of 4zux by Molmil
SAGA DUB module Ubp8/Sgf11/Sus1/Sgf73 bound to ubiqitinated nucleosome
Descriptor: DNA (145-MER), Histone H2A type 1, Histone H2B 1.1, ...
Authors:Morgan, M, Wolberger, C.
Deposit date:2015-05-17
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (3.82 Å)
Cite:Structural basis for histone H2B deubiquitination by the SAGA DUB module.
Science, 351, 2016
8T3T
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BU of 8t3t by Molmil
Structure of Bre1-nucleosome complex - state3
Descriptor: 601 DNA strand 1, 601 DNA strand 2, E3 ubiquitin-protein ligase BRE1, ...
Authors:Zhao, F, Hicks, C.W, Wolberger, C.
Deposit date:2023-06-07
Release date:2023-10-18
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Mechanism of histone H2B monoubiquitination by Bre1.
Nat.Struct.Mol.Biol., 30, 2023
8T3Y
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BU of 8t3y by Molmil
Structure of Bre1-nucleosome complex - state1
Descriptor: 601 DNA Strand 1, 601 DNA Strand 2, E3 ubiquitin-protein ligase BRE1, ...
Authors:Zhao, F, Hicks, C.W, Wolberger, C.
Deposit date:2023-06-08
Release date:2023-10-18
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Mechanism of histone H2B monoubiquitination by Bre1.
Nat.Struct.Mol.Biol., 30, 2023
8T3W
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BU of 8t3w by Molmil
Structure of Bre1-nucleosome complex - state2
Descriptor: 601 DNA strand 1, 601 DNA strand 2, E3 ubiquitin-protein ligase BRE1, ...
Authors:Zhao, F, Hicks, C.W, Wolberger, C.
Deposit date:2023-06-07
Release date:2023-10-18
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Mechanism of histone H2B monoubiquitination by Bre1.
Nat.Struct.Mol.Biol., 30, 2023
8G6G
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BU of 8g6g by Molmil
H2BK120ub+H3K79me2-modified nucleosome ubiquitin position 5
Descriptor: 601 DNA (185-MER), Histone H2A, Histone H2B 1.1, ...
Authors:Hicks, C.W, Wolberger, C.
Deposit date:2023-02-15
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:Ubiquitinated H2B as gatekeeper of the nucleosome acidic patch
To Be Published
8G6S
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BU of 8g6s by Molmil
H2AK119ub-modified nucleosome ubiquitin position 2
Descriptor: 601 DNA (145-MER), Histone H2A, Histone H2B 1.1, ...
Authors:Hicks, C.W, Wolberger, C.
Deposit date:2023-02-15
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Ubiquitinated H2B as gatekeeper of the nucleosome acidic patch
To Be Published
8G6Q
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BU of 8g6q by Molmil
H2AK119ub-modified nucleosome ubiquitin position 1
Descriptor: 601 DNA (145-MER), Histone H2A, Histone H2B 1.1, ...
Authors:Hicks, C.W, Wolberger, C.
Deposit date:2023-02-15
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Ubiquitinated H2B as gatekeeper of the nucleosome acidic patch
To Be Published
8G6H
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BU of 8g6h by Molmil
H2BK120ub+H3K79me2-modified nucleosome ubiquitin position 6
Descriptor: 601 DNA (185-MER), Histone H2A, Histone H2B 1.1, ...
Authors:Hicks, C.W, Wolberger, C.
Deposit date:2023-02-15
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Ubiquitinated H2B as gatekeeper of the nucleosome acidic patch
To Be Published
6NOG
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BU of 6nog by Molmil
Poised-state Dot1L bound to the H2B-Ubiquitinated nucleosome
Descriptor: 601 DNA Strand 1, 601 DNA Strand 2, Histone H2A type 1, ...
Authors:Worden, E.J, Hoffmann, N.A, Wolberger, C.
Deposit date:2019-01-16
Release date:2019-02-20
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.
Cell, 176, 2019
6NJ9
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BU of 6nj9 by Molmil
Active state Dot1L bound to the H2B-Ubiquitinated nucleosome, 2-to-1 complex
Descriptor: 601 DNA Strand 1, 601 DNA Strand 2, Histone H2A type 1, ...
Authors:Worden, E.J, Hoffmann, N.A, Wolberger, C.
Deposit date:2019-01-02
Release date:2019-02-20
Last modified:2021-06-16
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.
Cell, 176, 2019

 

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