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1FXY
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BU of 1fxy by Molmil
COAGULATION FACTOR XA-TRYPSIN CHIMERA INHIBITED WITH D-PHE-PRO-ARG-CHLOROMETHYLKETONE
Descriptor: COAGULATION FACTOR XA-TRYPSIN CHIMERA, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
Authors:Hopfner, K.P, Kopetzki, E, Kresse, G.-B, Huber, R, Bode, W, Engh, R.A.
Deposit date:1998-04-22
Release date:1998-06-17
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:New enzyme lineages by subdomain shuffling.
Proc.Natl.Acad.Sci.USA, 95, 1998
1F2U
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BU of 1f2u by Molmil
Crystal Structure of RAD50 ABC-ATPase
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RAD50 ABC-ATPASE
Authors:Hopfner, K.P, Karcher, A, Shin, D.S, Craig, L.
Deposit date:2000-05-29
Release date:2000-08-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily.
Cell(Cambridge,Mass.), 101, 2000
1F2T
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BU of 1f2t by Molmil
Crystal Structure of ATP-Free RAD50 ABC-ATPase
Descriptor: RAD50 ABC-ATPASE
Authors:Hopfner, K.P, Karcher, A, Shin, D.S, Craig, L.
Deposit date:2000-05-29
Release date:2000-08-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily.
Cell(Cambridge,Mass.), 101, 2000
1L8D
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BU of 1l8d by Molmil
Rad50 coiled-coil Zn hook
Descriptor: CITRIC ACID, DNA double-strand break repair rad50 ATPase, MERCURY (II) ION, ...
Authors:Hopfner, K.P, Tainer, J.A.
Deposit date:2002-03-20
Release date:2002-08-28
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair.
Nature, 418, 2002
2BA1
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BU of 2ba1 by Molmil
Archaeal exosome core
Descriptor: Archaeal exosome RNA binding protein CSL4, Archaeal exosome complex exonuclease RRP41, Archaeal exosome complex exonuclease RRP42, ...
Authors:Hopfner, K.P, Buttner, K, Wenig, K.
Deposit date:2005-10-13
Release date:2005-11-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural framework for the mechanism of archaeal exosomes in RNA processing.
Mol.Cell, 20, 2005
1S8E
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BU of 1s8e by Molmil
Crystal structure of Mre11-3
Descriptor: MANGANESE (II) ION, exonuclease putative
Authors:Hopfner, K.P.
Deposit date:2004-02-02
Release date:2004-08-10
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional analysis of Mre11-3
Nucleic Acids Res., 32, 2004
3RA7
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BU of 3ra7 by Molmil
Bispecific digoxigenin binding antibodies for targeted payload delivery
Descriptor: DIGOXIGENIN, Fab fragment, heavy chain, ...
Authors:Hopfner, K.P, Lammens, A.
Deposit date:2011-03-27
Release date:2011-07-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:Bispecific digoxigenin-binding antibodies for targeted payload delivery
Proc.Natl.Acad.Sci.USA, 108, 2011
4LEO
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BU of 4leo by Molmil
Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human Her3 (ERBB3)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RG7116 Fab heavy chain, ...
Authors:Schiller, C.B, Hopfner, K.P.
Deposit date:2013-06-26
Release date:2013-07-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation.
Cancer Res., 73, 2013
2XGP
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BU of 2xgp by Molmil
Yeast DNA polymerase eta in complex with C8-2-acetylaminofluorene containing DNA
Descriptor: 5'-D(*CP*8FG*CP*TP*CP*AP*TP*CP*CP*AP*C)-3', 5'-D(*GP*TP*GP*GP*AP*TP*GP*AP*G)-3', CALCIUM ION, ...
Authors:Scheider, S, Lammens, K, Schorr, S, Hopfner, K.P, Carell, T.
Deposit date:2010-06-07
Release date:2010-11-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of Replication Blocking and Bypass of Y-Family Polymerase Eta by Bulky Acetylaminofluorene DNA Adducts.
Proc.Natl.Acad.Sci.USA, 107, 2010
5M1X
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BU of 5m1x by Molmil
Crystal structure of S. cerevisiae Rfa1 N-OB domain mutant (K45E)
Descriptor: Replication factor A protein 1
Authors:Seeber, A, Hegnauer, A.M, Hustedt, N, Deshpande, I, Poli, J, Eglinger, J, Pasero, P, Gut, H, Shinohara, M, Hopfner, K.P, Shimada, K, Gasser, S.M.
Deposit date:2016-10-11
Release date:2016-12-07
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together.
Mol. Cell, 64, 2016
3C1Y
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BU of 3c1y by Molmil
Structure of bacterial DNA damage sensor protein with co-purified and co-crystallized ligand
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, DNA integrity scanning protein disA
Authors:Witte, G, Hartung, S, Buttner, K, Hopfner, K.P.
Deposit date:2008-01-24
Release date:2008-05-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates
Mol.Cell, 30, 2008
3C21
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BU of 3c21 by Molmil
Structure of a bacterial DNA damage sensor protein with reaction product
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, DNA integrity scanning protein disA
Authors:Witte, G, Hartung, S, Buttner, K, Hopfner, K.P.
Deposit date:2008-01-24
Release date:2008-05-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates
Mol.Cell, 30, 2008
2BA0
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BU of 2ba0 by Molmil
Archaeal exosome core
Descriptor: Archaeal exosome RNA binding protein RRP4, Archaeal exosome RNA binding protein RRP41, Archaeal exosome RNA binding protein RRP42
Authors:Buttner, K, Wenig, K, Hopfner, K.P.
Deposit date:2005-10-13
Release date:2005-11-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural framework for the mechanism of archaeal exosomes in RNA processing.
Mol.Cell, 20, 2005
2P6R
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BU of 2p6r by Molmil
Crystal structure of superfamily 2 helicase Hel308 in complex with unwound DNA
Descriptor: 25-MER, 5'-D(*CP*TP*AP*GP*AP*GP*AP*CP*TP*AP*TP*CP*GP*AP*T)-3', afUHEL308 HELICASE
Authors:Buettner, K, Nehring, S, Hopfner, K.P.
Deposit date:2007-03-19
Release date:2007-06-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for DNA duplex separation by a superfamily-2 helicase.
Nat.Struct.Mol.Biol., 14, 2007
2P6U
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BU of 2p6u by Molmil
Apo structure of the Hel308 superfamily 2 helicase
Descriptor: PHOSPHATE ION, afuHEL308 HELICASE
Authors:Buettner, K, Nehring, S, Hopfner, K.P.
Deposit date:2007-03-19
Release date:2007-06-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Structural basis for DNA duplex separation by a superfamily-2 helicase.
Nat.Struct.Mol.Biol., 14, 2007
2QFD
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BU of 2qfd by Molmil
Crystal structure of the regulatory domain of human RIG-I with bound Hg
Descriptor: MERCURY (II) ION, Probable ATP-dependent RNA helicase DDX58
Authors:Cui, S, Lammens, A, Lammens, K, Hopfner, K.P.
Deposit date:2007-06-27
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I.
Mol.Cell, 29, 2008
4ON9
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BU of 4on9 by Molmil
DECH box helicase domain
Descriptor: CHLORIDE ION, Probable ATP-dependent RNA helicase DDX58, SULFATE ION
Authors:Deimling, T, Witte, G, Hopfner, K.P.
Deposit date:2014-01-28
Release date:2014-07-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal and solution structure of the human RIG-I SF2 domain
Acta Crystallogr.,Sect.F, 70, 2014
7A08
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BU of 7a08 by Molmil
CryoEM Structure of cGAS Nucleosome complex
Descriptor: Cyclic GMP-AMP synthase, Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, ...
Authors:Michalski, S, de Oliveira Mann, C.C, Witte, G, Bartho, J, Lammens, K, Hopfner, K.P.
Deposit date:2020-08-07
Release date:2020-09-23
Last modified:2021-02-10
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Structural basis for sequestration and autoinhibition of cGAS by chromatin.
Nature, 587, 2020
2W4R
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BU of 2w4r by Molmil
Crystal structure of the regulatory domain of human LGP2
Descriptor: MERCURY (II) ION, PROBABLE ATP-DEPENDENT RNA HELICASE DHX58, SULFATE ION
Authors:Pippig, D.A, Hellmuth, J.C, Cui, S, Kirchhofer, A, Lammens, K, Lammens, A, Schmidt, A, Rothenfusser, S, Hopfner, K.P.
Deposit date:2008-12-01
Release date:2009-02-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Regulatory Domain of the Rig-I Family ATPase Lgp2 Senses Double-Stranded RNA.
Nucleic Acids Res., 37, 2009
2QFB
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BU of 2qfb by Molmil
Crystal structure of the regulatory domain of human RIG-I with bound Zn
Descriptor: Probable ATP-dependent RNA helicase DDX58, ZINC ION
Authors:Cui, S, Lammens, A, Lammens, K, Hopfner, K.P.
Deposit date:2007-06-27
Release date:2008-02-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I.
Mol.Cell, 29, 2008
3KTA
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BU of 3kta by Molmil
Structural Basis for Adenylate Kinase Activity in ABC ATPases
Descriptor: BIS(ADENOSINE)-5'-PENTAPHOSPHATE, Chromosome segregation protein smc, MAGNESIUM ION
Authors:Lammens, A, Hopfner, K.P.
Deposit date:2009-11-24
Release date:2010-06-30
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.627 Å)
Cite:Structural Basis for Adenylate Kinase Activity in ABC ATPases.
J.Mol.Biol., 401, 2010
1US8
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BU of 1us8 by Molmil
The Rad50 signature motif: essential to ATP binding and biological function
Descriptor: DNA DOUBLE-STRAND BREAK REPAIR RAD50 ATPASE
Authors:Moncalian, G, Lengsfeld, B, Bhaskara, V, Hopfner, K.P, Karcher, A, Alden, E, Tainer, J.A, Paull, T.T.
Deposit date:2003-11-20
Release date:2003-11-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Rad50 Signature Motif: Essential to ATP Binding and Biological Function
J.Mol.Biol., 335, 2004
6SKY
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BU of 6sky by Molmil
FAT and kinase domain of CtTel1
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1
Authors:Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P.
Deposit date:2019-08-16
Release date:2019-10-30
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
Structure, 28, 2020
6SL0
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BU of 6sl0 by Molmil
Complete CtTel1 dimer with C2 symmetry
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1
Authors:Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P.
Deposit date:2019-08-16
Release date:2019-10-30
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
Structure, 28, 2020
5NBL
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BU of 5nbl by Molmil
Crystal structure of the Arp4-N-actin(APO-state) heterodimer bound by a nanobody
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, Actin-related protein 4, ...
Authors:Knoll, K.R, Eustermann, S, Hopfner, K.P.
Deposit date:2017-03-02
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling.
Nat. Struct. Mol. Biol., 25, 2018

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PDB entries from 2024-09-18

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