1FXY

COAGULATION FACTOR XA-TRYPSIN CHIMERA INHIBITED WITH D-PHE-PRO-ARG-CHLOROMETHYLKETONE

Summary for 1FXY

Entry DOI	10.2210/pdb1fxy/pdb
Related PRD ID	PRD_000020
Descriptor	COAGULATION FACTOR XA-TRYPSIN CHIMERA, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide (3 entities in total)
Functional Keywords	chimera, protease, chloromethylketone, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space: P07477
Total number of polymer chains	1
Total formula weight	25122.80
Authors	Hopfner, K.P.,Kopetzki, E.,Kresse, G.-B.,Huber, R.,Bode, W.,Engh, R.A. (deposition date: 1998-04-22, release date: 1998-06-17, Last modification date: 2013-02-27)
Primary citation	Hopfner, K.P.,Kopetzki, E.,Kresse, G.B.,Bode, W.,Huber, R.,Engh, R.A. New enzyme lineages by subdomain shuffling. Proc.Natl.Acad.Sci.USA, 95:9813-9818, 1998 Cited by PubMed: 9707558 DOI: 10.1073/pnas.95.17.9813 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation