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6U2N	PCSK9 in complex with compound 4 Descriptor: 4-{[(1R)-6-methoxy-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid, Proprotein convertase subtilisin/kexin type 9 Authors: Lu, J, Soisson, S. Deposit date: 2019-08-20 Release date: 2019-11-06 Last modified: 2020-01-29 Method: X-RAY DIFFRACTION (2.15 Å) Cite: From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol, 27, 2020
6U3I	Design of organo-peptides as bipartite PCSK9 antagonists Descriptor: 7G7 heavy chain, 7G7 light chain, CALCIUM ION, ... Authors: Ultsch, M.H, Kirchhofer, D. Deposit date: 2019-08-21 Release date: 2020-02-05 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Design of Organo-Peptides As Bipartite PCSK9 Antagonists. Acs Chem.Biol., 15, 2020
6U2F	PCSK9-Fab 7G7 complex bound to cis-1-amino-4-phenylcyclohexaneacyl-WNLK(hR)IGLLR - NH2 Descriptor: 7G7 heavy chain, 7G7 light chain, CALCIUM ION, ... Authors: Ultsch, M.H, Kirchhofer, D. Deposit date: 2019-08-19 Release date: 2020-02-05 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.94 Å) Cite: Design of Organo-Peptides As Bipartite PCSK9 Antagonists. Acs Chem.Biol., 15, 2020
6U36	PCSK9 in complex with a Fab and compound 14 Descriptor: 2-fluoro-4-{[(1R)-6-(2-{4-[1-(4-methoxyphenyl)-5-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-1H-1,2,3-triazol-1-yl}ethoxy)-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid, Fab Heavy Chain, Fab Light Chain, ... Authors: Lu, J, Soisson, S. Deposit date: 2019-08-21 Release date: 2019-11-06 Last modified: 2020-01-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol, 27, 2020
6U3X	PCSK9 in complex with compound 2 Descriptor: 2-[(1R)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]-N-(1,3-thiazol-2-yl)acetamide, Proprotein convertase subtilisin/kexin type 9 Authors: Lu, J, Soisson, S. Deposit date: 2019-08-22 Release date: 2019-11-06 Last modified: 2020-01-29 Method: X-RAY DIFFRACTION (2.64 Å) Cite: From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol, 27, 2020
6U26	PCSK9 in complex with compound 16 Descriptor: 4'-{[(1R)-6-{2-[2-({N~5~-[N,N'-bis(tert-butoxycarbonyl)carbamimidoyl]-N~2~-(tert-butoxycarbonyl)-L-ornithyl}amino)ethoxy]ethoxy}-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}-2'-fluoro[1,1'-biphenyl]-4-carboxylic acid, Proprotein convertase subtilisin/kexin type 9 Authors: Orth, P. Deposit date: 2019-08-19 Release date: 2019-11-06 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.53 Å) Cite: From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol, 27, 2020
6U2P	PCSK9 in complex with compound 5 Descriptor: 1,2-ETHANEDIOL, 2-fluoro-4-{[(1R)-6-methoxy-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid, Proprotein convertase subtilisin/kexin type 9 Authors: Lu, J, Soisson, S. Deposit date: 2019-08-20 Release date: 2019-11-06 Last modified: 2020-01-29 Method: X-RAY DIFFRACTION (2.04 Å) Cite: From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol, 27, 2020

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