PDB: 69 resultsInfo pagesStatus searchChemie searchBIRD

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2ZLG	The Structual Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase Descriptor: (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL, Ribonucleoside-diphosphate reductase large chain 1 Authors: Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C. Deposit date: 2008-04-09 Release date: 2008-08-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.52 Å) Cite: The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore J.Med.Chem., 51, 2008
2EUD	Structures of Yeast Ribonucleotide Reductase I complexed with Ligands and Subunit Peptides Descriptor: GEMCITABINE DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Dealwis, C, Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J. Deposit date: 2005-10-28 Release date: 2006-03-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly. Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVU	Structures of Yeast Ribonucleotide Reductase I Descriptor: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. Deposit date: 2005-06-14 Release date: 2006-03-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVS	Structures of Yeast Ribonucleotide Reductase I Descriptor: Ribonucleoside-diphosphate reductase large chain 1 Authors: Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. Deposit date: 2005-06-14 Release date: 2006-03-07 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVT	Structures of Yeast Ribonucleotide Reductase I Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribonucleoside-diphosphate reductase large chain 1 Authors: Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. Deposit date: 2005-06-14 Release date: 2006-03-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVX	Structures of Yeast Ribonucleotide Reductase I Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. Deposit date: 2005-06-14 Release date: 2006-03-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVV	Structures of Yeast Ribonucleotide Reductase I Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribonucleoside-diphosphate reductase large chain 1, ... Authors: Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. Deposit date: 2005-06-14 Release date: 2006-03-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVW	Structures of Yeast Ribonucleotide Reductase I Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1, ... Authors: Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. Deposit date: 2005-06-14 Release date: 2006-03-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVY	Structures of Yeast Ribonucleotide Reductase I Descriptor: 9-per peptide from Ribonucleoside-diphosphate reductase small chain 1, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1, ... Authors: Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. Deposit date: 2005-06-14 Release date: 2006-03-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
1ZYZ	Structures of Yeast Ribonucloetide Reductase I Descriptor: GLYCINE, Ribonucleoside-diphosphate reductase large chain 1 Authors: Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. Deposit date: 2005-06-13 Release date: 2006-03-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
1ZZD	Structures of Yeast Ribonucleotide Reductase I Descriptor: Ribonucleoside-diphosphate reductase large chain 1, Ribonucleoside-diphosphate reductase small chain 2 Authors: Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. Deposit date: 2005-06-13 Release date: 2006-03-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
5R1R	RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN Authors: Eriksson, M, Eklund, H. Deposit date: 1997-09-17 Release date: 1998-03-18 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3.1 Å) Cite: A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997
7R1R	RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN Authors: Eriksson, M, Eklund, H. Deposit date: 1997-09-17 Release date: 1998-03-18 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3.1 Å) Cite: A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997
6R1R	RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN Authors: Eriksson, M, Eklund, H. Deposit date: 1997-09-17 Release date: 1998-03-18 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3.1 Å) Cite: A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997
4R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI Descriptor: GUANOSINE-5'-DIPHOSPHATE, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, ... Authors: Eriksson, M, Eklund, H. Deposit date: 1997-07-22 Release date: 1998-01-28 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
2R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, THYMIDINE-5'-TRIPHOSPHATE Authors: Eriksson, M, Eklund, H. Deposit date: 1997-07-21 Release date: 1998-01-28 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
3R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI Descriptor: ADENOSINE-5'-TRIPHOSPHATE, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN Authors: Eriksson, M, Eklund, H. Deposit date: 1997-07-21 Release date: 1998-01-28 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
1R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN Authors: Eriksson, M, Eklund, H. Deposit date: 1997-07-15 Release date: 1998-01-28 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
1RLR	STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1 Descriptor: RIBONUCLEOTIDE REDUCTASE PROTEIN R1 Authors: Uhlin, U, Eklund, H. Deposit date: 1994-08-12 Release date: 1996-12-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of ribonucleotide reductase protein R1. Nature, 370, 1994

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