8G4U
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6WC7
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8I4Z
| CalA3 with hydrolysis product | 分子名称: | 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, Beta-ketoacyl-acyl-carrier-protein synthase I | 著者 | Wang, J, Wang, Z. | 登録日 | 2023-01-21 | 公開日 | 2023-02-22 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | 主引用文献 | C-N bond formation by a polyketide synthase. Nat Commun, 14, 2023
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8I4Y
| CalA3 complex structure with amidation product | 分子名称: | 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, 3-HYDROXYANTHRANILIC ACID, Beta-ketoacyl-acyl-carrier-protein synthase I | 著者 | Wang, J, Wang, Z. | 登録日 | 2023-01-21 | 公開日 | 2023-02-22 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | 主引用文献 | C-N bond formation by a polyketide synthase. Nat Commun, 14, 2023
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7WVZ
| CalA3_modular PKS_KS-AT-DH-KR | 分子名称: | Beta-ketoacyl-acyl-carrier-protein synthase I | 著者 | Wang, J, Wang, Z. | 登録日 | 2022-02-12 | 公開日 | 2023-02-22 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | C-N bond formation by a polyketide synthase. Nat Commun, 14, 2023
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7SZ9
| Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C16:1-crypto Acyl Carrier Protein, AcpP | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N~3~-{(2R)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-(2-{[(9Z)-hexadec-9-enoyl]amino}ethyl)-beta-alaninamide, ... | 著者 | Mindrebo, J.T, Chen, A, Noel, J.P, Burkart, M.D. | 登録日 | 2021-11-26 | 公開日 | 2022-11-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states. Acta Crystallogr D Struct Biol, 78, 2022
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7TUI
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7UK4
| KS-AT di-domain of mycobacterial Pks13 with endogenous KS ligand bound | 分子名称: | Polyketide synthase PKS13, UNKNOWN LIGAND | 著者 | Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. | 登録日 | 2022-03-31 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (1.94 Å) | 主引用文献 | Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
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7VEE
| The ligand-free structure of GfsA KSQ-AT didomain | 分子名称: | GLYCEROL, Polyketide synthase | 著者 | Chisuga, T, Miyanaga, A, Nagai, A, Kudo, F, Eguchi, T. | 登録日 | 2021-09-08 | 公開日 | 2022-01-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases. Acs Chem.Biol., 17, 2022
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7VEF
| The structure of GfsA KSQ-AT didomain in complex with a malonate substrate analog | 分子名称: | GLYCEROL, N-(2-acetamidoethyl)-2-nitro-ethanamide, Polyketide synthase | 著者 | Chisuga, T, Miyanaga, A, Nagai, A, Kudo, F, Eguchi, T. | 登録日 | 2021-09-08 | 公開日 | 2022-01-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases. Acs Chem.Biol., 17, 2022
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7UWR
| KSQ+AT from first module of the pikromycin synthase | 分子名称: | Narbonolide/10-deoxymethynolide synthase PikA1, modules 1 and 2 | 著者 | Keatinge-Clay, A.T, Dickinson, M.S, Miyazawa, T, McCool, R.S. | 登録日 | 2022-05-03 | 公開日 | 2022-06-08 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry. Structure, 30, 2022
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7ZMC
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7ZMD
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7ZM9
| Ketosynthase domain 3 of Brevibacillus Brevis orphan BGC11 | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Putative polyketide synthase | 著者 | Tittes, Y.U, Herbst, D.A, Jakob, R.P, Maier, T. | 登録日 | 2022-04-19 | 公開日 | 2022-09-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | The structure of a polyketide synthase bimodule core. Sci Adv, 8, 2022
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7ZMA
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6KOG
| Ketosynthase domain in tenuazonic acid synthetase 1 (TAS1). | 分子名称: | GLYCEROL, Hybrid PKS-NRPS synthetase TAS1, SULFATE ION | 著者 | Yun, C.S, Nishimoto, K, Motoyama, T, Hino, T, Nagano, S, Osada, H. | 登録日 | 2019-08-10 | 公開日 | 2020-07-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Unique features of the ketosynthase domain in a nonribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1. J.Biol.Chem., 295, 2020
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6KXE
| The ishigamide ketosynthase/chain length factor | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Ketosynthase, ... | 著者 | Du, D, Katsuyama, Y, Horiuchi, M, Fushinobu, S, Chen, A, Davis, T, Burkart, M, Ohnishi, Y. | 登録日 | 2019-09-10 | 公開日 | 2020-05-06 | 最終更新日 | 2020-07-08 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structural basis for selectivity in a highly reducing type II polyketide synthase. Nat.Chem.Biol., 16, 2020
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6KXF
| The ishigamide ketosynthase/chain length factor | 分子名称: | ACP, Ketosynthase, [(3~{R})-2,2-dimethyl-4-[[3-[2-[[(~{E})-oct-2-enoyl]amino]ethylamino]-3-oxidanylidene-propyl]amino]-3-oxidanyl-4-oxidanylidene-butyl] dihydrogen phosphate | 著者 | Du, D, Katsuyama, Y, Horiuchi, M, Fushinobu, S, Chen, A, Davis, T, Burkart, M, Ohnishi, Y. | 登録日 | 2019-09-10 | 公開日 | 2020-05-06 | 最終更新日 | 2020-07-08 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structural basis for selectivity in a highly reducing type II polyketide synthase. Nat.Chem.Biol., 16, 2020
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6KXD
| The ishigamide ketosynthase/chain length factor | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Ketosynthase, ... | 著者 | Du, D, Katsuyama, Y, Horiuchi, M, Fushinobu, S, Chen, A, Davis, T, Burkart, M, Ohnishi, Y. | 登録日 | 2019-09-10 | 公開日 | 2020-05-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural basis for selectivity in a highly reducing type II polyketide synthase. Nat.Chem.Biol., 16, 2020
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7ZSK
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6MHK
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6MHL
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5BP1
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7PPS
| apo FabB from Pseudomonas aeruginosa with single point mutation C161A | 分子名称: | 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 1, CHLORIDE ION, ... | 著者 | Georgiou, C, Brenk, R, Yadrykhinsky, V. | 登録日 | 2021-09-15 | 公開日 | 2021-10-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics. F1000Res, 10, 2021
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7Q5S
| Protein community member fatty acid synthase complex from C. thermophilum | 分子名称: | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, 3-oxoacyl-[acyl-carrier-protein] reductase | 著者 | Chojnowski, G, Skalidis, I, Kyrilis, F.L, Tueting, C, Hamdi, F, Kastritis, P.L. | 登録日 | 2021-11-04 | 公開日 | 2022-02-02 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (4.47 Å) | 主引用文献 | Cryo-EM and artificial intelligence visualize endogenous protein community members. Structure, 30, 2022
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