PDB: 322 resultsInfo pagesStatus searchChemie searchBIRD

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8PBI	Mutant R1617Q of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoroorotate Descriptor: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... Authors: del Cano-Ochoa, F, Ramon-Maiques, S. Deposit date: 2023-06-09 Release date: 2023-11-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBJ	Mutant R1722W of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate Descriptor: CAD protein, FORMIC ACID, GLYCEROL, ... Authors: del Cano-Ochoa, F, Ramon-Maiques, S. Deposit date: 2023-06-09 Release date: 2023-11-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBH	Mutant R1617Q of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate Descriptor: CAD protein, FORMIC ACID, N-CARBAMOYL-L-ASPARTATE, ... Authors: del Cano-Ochoa, F, Ramon-Maiques, S. Deposit date: 2023-06-09 Release date: 2023-11-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
1GKP	D-Hydantoinase (Dihydropyrimidinase) from Thermus sp. in space group C2221 Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HYDANTOINASE, SULFATE ION, ... Authors: Abendroth, J, Niefind, K, Schomburg, D. Deposit date: 2001-08-20 Release date: 2002-06-27 Last modified: 2019-07-24 Method: X-RAY DIFFRACTION (1.295 Å) Cite: X-Ray Structure of a Dihydropyrimidinase from Thermus Sp. At 1.3 A Resolution J.Mol.Biol., 320, 2002
1GKR	L-Hydantoinase (Dihydropyrimidinase) from Arthrobacter aurescens Descriptor: NON-ATP DEPENDENT L-SELECTIVE HYDANTOINASE, ZINC ION Authors: Abendroth, J, Niefind, K, Schomburg, D. Deposit date: 2001-08-20 Release date: 2002-07-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The structure of L-hydantoinase from Arthobacter aurescens leads to an understanding of dihydropyrimidinase substrate and enantio specificity. Biochemistry, 41, 2002
1GKQ	D-Hydantoinase (Dihydropyrimidinase) from Thermus sp. in space group P212121 Descriptor: HYDANTOINASE, ZINC ION Authors: Abendroth, J, Niefind, K, Schomburg, D. Deposit date: 2001-08-20 Release date: 2002-06-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: X-Ray Structure of a Dihydropyrimidinase from Thermus Sp. At 1.3 A Resolution J.Mol.Biol., 320, 2002
1J79	Molecular Structure of Dihydroorotase: A Paradigm for Catalysis Through the Use of a Binuclear Metal Center Descriptor: N-CARBAMOYL-L-ASPARTATE, OROTIC ACID, ZINC ION, ... Authors: Thoden, J.B, Phillips Jr, G.N, Neal, T.M, Raushel, F.M, Holden, H.M. Deposit date: 2001-05-16 Release date: 2001-06-20 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center. Biochemistry, 40, 2001
1J6P	Crystal structure of Metal-dependent hydrolase of cytosinedemaniase/chlorohydrolase family (TM0936) from Thermotoga maritima at 1.9 A resolution Descriptor: METAL-DEPENDENT HYDROLASE OF CYTOSINEDEMANIASE/CHLOROHYDROLASE FAMILY, NICKEL (II) ION Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2002-07-09 Release date: 2002-10-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of Metal-dependent hydrolase of cytosinedemaniase/chlorohydrolase family (TM0936) from Thermotoga maritima at 1.9 A resolution To be published
6GDD	DIHYDROOROTASE FROM AQUIFEX AEOLICUS UNDER 1200 BAR OF HYDROSTATIC PRESSURE Descriptor: Dihydroorotase, SULFATE ION, ZINC ION Authors: Prange, T, Girard, E, Herve, G, Evans, D.R. Deposit date: 2018-04-23 Release date: 2019-01-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Pressure-induced activation of latent dihydroorotase from Aquifex aeolicus as revealed by high pressure protein crystallography. Febs J., 286, 2019
6FV4	The structure of N-acetyl-D-glucosamine-6-phosphate deacetylase D267A mutant from Mycobacterium smegmatis in complex with N-acetyl-D-glucosamine-6-phosphate Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-acetamido-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, CADMIUM ION, ... Authors: Ahangar, M.S, Furze, C.M, Guy, C.S, Cooper, C, Maskew, K.S, Graham, B, Cameron, A.D, Fullam, E. Deposit date: 2018-03-01 Release date: 2018-05-16 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.974 Å) Cite: Structural and functional determination of homologs of theMycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA). J. Biol. Chem., 293, 2018
6GDF	DIHYDROOROTASE FROM AQUIFEX AEOLICUS UNDER 600 BAR OF HYDROSTATIC PRESSURE Descriptor: Dihydroorotase, SULFATE ION, ZINC ION Authors: Prange, T, Girard, E, Herve, G, Evans, D.R. Deposit date: 2018-04-23 Release date: 2019-01-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Pressure-induced activation of latent dihydroorotase from Aquifex aeolicus as revealed by high pressure protein crystallography. Febs J., 286, 2019
6HFD	Human dihydroorotase mutant F1563L apo structure Descriptor: CAD protein, FORMIC ACID, ZINC ION Authors: Ramon-Maiques, S, Grande Garcia, A. Deposit date: 2018-08-21 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.869968 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HFK	Human dihydroorotase mutant F1563L co-crystallized with carbamoyl aspartate at pH 6.5 Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... Authors: Ramon-Maiques, S, Grande Garcia, A. Deposit date: 2018-08-21 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.459144 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HFL	Human dihydroorotase mutant F1563L co-crystallized with carbamoyl aspartate at pH 7.0 Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... Authors: Ramon-Maiques, S, Grande Garcia, A. Deposit date: 2018-08-21 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HG1	Hybrid dihydroorotase domain of human CAD with E. coli flexible loop in apo state Descriptor: CAD protein,Dihydroorotase,CAD protein, FORMIC ACID, ZINC ION Authors: Ramon-Maiques, S, Del Cano-Ochoa, F. Deposit date: 2018-08-22 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HFF	Human dihydroorotase mutant F1563Y apo structure Descriptor: CAD protein, FORMIC ACID, ZINC ION Authors: Ramon-Maiques, S, Grande Garcia, A. Deposit date: 2018-08-21 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.51000106 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HFQ	Human dihydroorotase mutant F1563T co-crystallized with carbamoyl aspartate at pH 7.5 Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... Authors: Ramon-Maiques, S, Grande Garcia, A. Deposit date: 2018-08-21 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.1454246 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HFE	Human dihydroorotase mutant F1563T apo structure Descriptor: CAD protein, FORMIC ACID, ZINC ION Authors: Ramon-Maiques, S, Grande Garcia, A. Deposit date: 2018-08-21 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.47997439 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HFU	Human dihydroorotase mutant F1563Y co-crystallized with carbamoyl aspartate at pH 7.5 Descriptor: CAD protein, FORMIC ACID, N-CARBAMOYL-L-ASPARTATE, ... Authors: Ramon-Maiques, S, Grande Garcia, A. Deposit date: 2018-08-21 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.3997103 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HFN	Human dihydroorotase mutant F1563L co-crystallized with carbamoyl aspartate at pH 7.5 Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... Authors: Ramon-Maiques, S, Grande Garcia, A. Deposit date: 2018-08-21 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.44965148 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HFP	Human dihydroorotase mutant F1563T co-crystallized with carbamoyl aspartate at pH 7.0 Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... Authors: Ramon-Maiques, S, Grande Garcia, A. Deposit date: 2018-08-21 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.1982286 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HG3	Hybrid dihydroorotase domain of human CAD with E. coli flexible loop, bound to dihydroorotate Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... Authors: Ramon-Maiques, S, Del Cano-Ochoa, F. Deposit date: 2018-08-22 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HFH	Human dihydroorotase mutant F1563A co-crystallized with carbamoyl aspartate at pH 7.0 Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... Authors: Ramon-Maiques, S, Grande Garcia, A. Deposit date: 2018-08-21 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.44871271 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HFR	Human dihydroorotase mutant F1563Y co-crystallized with carbamoyl aspartate at pH 7.0 Descriptor: CAD protein, FORMIC ACID, N-CARBAMOYL-L-ASPARTATE, ... Authors: Ramon-Maiques, S, Grande Garcia, A. Deposit date: 2018-08-21 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.29949379 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018
6HG2	Hybrid dihydroorotase domain of human CAD with E. coli flexible loop, bound to fluoroorotate Descriptor: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... Authors: Ramon-Maiques, S, Del Cano-Ochoa, F. Deposit date: 2018-08-22 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018

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