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6JWR	Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with Pteroate Descriptor: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWU	Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with STZ-DHP Descriptor: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.65 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6KCL	Crystal structure of Plasmodium falciparum HPPK-DHPS A437G/K540E with pterin and p-hydroxybenzoate Descriptor: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-06-28 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWV	Crystal structure of Plasmodium falciparum HPPK-DHPS A437G with STZ-DHP Descriptor: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
6JWW	Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with STZ-DHP Descriptor: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.75 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
2CG8	The bifunctional dihydroneopterin aldolase 6-hydroxymethyl-7,8- dihydropterin synthase from Streptococcus pneumoniae Descriptor: DIHYDRONEOPTERIN ALDOLASE 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN SYNTHASE Authors: Garcon, A, Levy, C, Derrick, J.P. Deposit date: 2006-02-28 Release date: 2006-06-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal Structure of the Bifunctional Dihydroneopterin Aldolase/6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase from Streptococcus Pneumoniae. J.Mol.Biol., 360, 2006
5Z79	Crystal Structure Analysis of the HPPK-DHPS in complex with substrates Descriptor: 4-AMINOBENZOIC ACID, 5'-DEOXYADENOSINE, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, ... Authors: Manickam, Y, Karl, H, Sharma, A. Deposit date: 2018-01-27 Release date: 2018-08-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance J. Biol. Chem., 293, 2018
6JWZ	Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613S triple mutant with SDX-DHP Descriptor: 4-[(2-azanyl-4-oxidanylidene-7,8-dihydro-3~{H}-pteridin-6-yl)methylamino]-~{N}-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, ... Authors: Chitnumsub, P, Jaruwat, A, Yuthavong, Y. Deposit date: 2019-04-21 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.95 Å) Cite: The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
2F65	Solution structure of HPPK in complex with inhibitor analog AMPCPP Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Authors: Yan, H, Li, G. Deposit date: 2005-11-28 Release date: 2006-01-17 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Solution structure of HPPK in complex with inhibitor analog AMPCPP to be published
2F63	Solution structure of HPPK in complex with inhibitor analogs AMPCPP and HP-1 Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Authors: Yan, H, Li, G. Deposit date: 2005-11-28 Release date: 2006-01-17 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Solution structure of HPPK in complex with inhibitor analogs AMPCPP and HP-1 To be Published
1EQ0	SOLUTION STRUCTURE OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE COMPLEXED WITH MGAMPPCP Descriptor: 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE Authors: Shi, G, Yan, H. Deposit date: 2000-03-30 Release date: 2001-11-07 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Unusual conformational changes in 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase as revealed by X-ray crystallography and NMR. J.Biol.Chem., 276, 2001

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