PDB: 250 件ウェブページステータス検索Chemie searchBIRD

---

6I8L	Crystal structure of Spindlin1 in complex with the inhibitor TD001851a 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 5'-(cyclopropylmethoxy)-6'-[3-(1,3-dihydroisoindol-2-yl)propoxy]spiro[cyclopentane-1,3'-indole]-2'-amine, ... 著者 Johansson, C, Fagan, V, Brennan, P.E, Sorrell, F.J, Krojer, T, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. 登録日 2018-11-20 公開日 2018-12-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62, 2019
5YVX	Crystal structure of SDG8 CW domain in complex with H3K4me1 peptide 分子名称: H3K4me1, Histone-lysine N-methyltransferase ASHH2, ZINC ION 著者 Liu, Y, Huang, Y. 登録日 2017-11-27 公開日 2018-03-14 最終更新日 2018-05-09 実験手法 X-RAY DIFFRACTION (1.591 Å) 主引用文献 Uncovering the mechanistic basis for specific recognition of monomethylated H3K4 by the CW domain ofArabidopsishistone methyltransferase SDG8. J. Biol. Chem., 293, 2018
5Y53	Crystal structure of AL2 PAL domain in complex with AtBMI1b binding site 分子名称: AtBMI1b binding site, PHD finger protein ALFIN-LIKE 2 著者 Peng, L, Wang, L.L, Huang, Y. 登録日 2017-08-07 公開日 2018-08-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.598 Å) 主引用文献 Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch J. Mol. Biol., 430, 2018
6QPL	Crystal structure of Spindlin1 in complex with the inhibitor MS31 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Johansson, C, Krojer, T, Xiong, Y, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. 登録日 2019-02-14 公開日 2019-07-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). J.Med.Chem., 62, 2019
3QLA	Hexagonal complex structure of ATRX ADD bound to H3K9me3 peptide 分子名称: POTASSIUM ION, Transcriptional regulator ATRX, ZINC ION, ... 著者 Xiang, B, Li, H. 登録日 2011-02-02 公開日 2011-06-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome Nat.Struct.Mol.Biol., 18, 2011
5C0M	Crystal structure of SGF29 tandem tudor domain in complex with a Carba containing peptide 分子名称: Carba-containing peptide, GLYCEROL, SAGA-associated factor 29 homolog, ... 著者 Dong, A, Xu, C, Tempel, W, Cerovina, T, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2015-06-12 公開日 2015-07-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins. Nat Commun, 6, 2015
7CNA	Crystal structure of Spindlin1/C11orf84 complex bound to histone H3K4me3K9me3 peptide 分子名称: ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-GLY, ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-THR, BENZAMIDINE, ... 著者 Qian, C.M. 登録日 2020-07-30 公開日 2021-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural mechanism of bivalent histone H3K4me3K9me3 recognition by the Spindlin1/C11orf84 complex in rRNA transcription activation. Nat Commun, 12, 2021
7CFP	Crystal structure of WDR5 in complex with a H3Q5ser peptide 分子名称: H3Q5ser peptide, SEROTONIN, WD repeat-containing protein 5 著者 Zhao, J, Zhang, X, Zang, J. 登録日 2020-06-27 公開日 2021-07-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021
7CFQ	Crystal structure of WDR5 in complex with H3K4me3Q5ser peptide 分子名称: 1,2-ETHANEDIOL, GLYCEROL, H3K4me3Q5ser peptide, ... 著者 Zhao, J, Zhang, X, Zang, J. 登録日 2020-06-27 公開日 2021-07-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021
4LK9	Crystal Structure of MOZ double PHD finger histone H3 tail complex 分子名称: Histone H3.1, Histone acetyltransferase KAT6A, ZINC ION 著者 Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. 登録日 2013-07-07 公開日 2013-10-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res., 42, 2014
4LKA	Crystal Structure of MOZ double PHD finger histone H3K9ac complex 分子名称: Histone H3.1, Histone acetyltransferase KAT6A, ZINC ION 著者 Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. 登録日 2013-07-07 公開日 2013-10-16 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res., 42, 2014
5XVL	Crystal structure of AL2 PAL domain 分子名称: PHD finger protein ALFIN-LIKE 2, SULFATE ION 著者 Peng, L, Wang, L.L, Huang, Y. 登録日 2017-06-28 公開日 2018-07-04 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.629 Å) 主引用文献 Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch J. Mol. Biol., 430, 2018
4PLI	Structure of the chromodomain of MRG2 in complex with H3K36me3 分子名称: At1g02740, H3K36me3 著者 Liu, Y, Huang, Y. 登録日 2014-05-18 公開日 2015-07-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.651 Å) 主引用文献 Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. Plos Genet., 10, 2014
3O7A	Crystal structure of PHF13 in complex with H3K4me3 分子名称: GLYCEROL, H3K4ME3 HISTONE 11MER-PEPTIDE, PHD finger protein 13 variant, ... 著者 Bian, C.B, Lam, R, Xu, C, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2010-07-30 公開日 2010-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3. Elife, 5, 2016
4PL6	Structure of the chromodomain of MRG2 in complex with H3K4me3 分子名称: At1g02740, H3K4me3 著者 Liu, Y.C, Huang, Y. 登録日 2014-05-16 公開日 2015-07-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.681 Å) 主引用文献 Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. Plos Genet., 10, 2014
4MZG	Crystal structure of human Spindlin1 bound to histone H3K4me3 peptide 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... 著者 Su, X, Ding, X, Li, H. 登録日 2013-09-30 公開日 2014-03-26 実験手法 X-RAY DIFFRACTION (1.698 Å) 主引用文献 Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1 Genes Dev., 28, 2014
5XMY	Crystal structure of TAF3 PHD finger bound to H3K4me3Q5ser 分子名称: Histone peptide H3(1-15)K4me3Q5ser, Transcription initiation factor TFIID subunit 3, ZINC ION 著者 Zhao, S, Zhang, B, Li, H. 登録日 2017-05-16 公開日 2018-11-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Crystal structure of TAF3 PHD finger bound to H3K4me3Q5ser to be published
5TDW	Set3 PHD finger in complex with histone H3K4me3 分子名称: SET domain-containing protein 3, SODIUM ION, ZINC ION, ... 著者 Andrews, F.H, Ali, M, Kutateladze, T.G. 登録日 2016-09-19 公開日 2016-10-19 最終更新日 2017-06-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Insight into Recognition of Methylated Histone H3K4 by Set3. J. Mol. Biol., 429, 2017
5WXG	Structure of TAF PHD finger domain binds to H3(1-15)K4ac 分子名称: Histone H3K4ac, MAGNESIUM ION, Transcription initiation factor TFIID subunit 3, ... 著者 Zhao, S, Li, H. 登録日 2017-01-07 公開日 2017-08-16 最終更新日 2017-09-13 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3LQH	Crystal structure of MLL1 PHD3-Bromo in the free form 分子名称: Histone-lysine N-methyltransferase MLL, ZINC ION 著者 Wang, Z, Patel, D.J. 登録日 2010-02-09 公開日 2010-07-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell(Cambridge,Mass.), 141, 2010
3C6W	Crystal structure of the ING5 PHD finger in complex with H3K4me3 peptide 分子名称: H3K4me3 histone peptide, Inhibitor of growth protein 5, ZINC ION 著者 Champagne, K.S, Pena, P.V, Johnson, K, Kutateladze, T.G. 登録日 2008-02-05 公開日 2008-06-03 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide. Proteins, 72, 2008
6I8B	Crystal structure of Spindlin1 in complex with the inhibitor VinSpinIn 分子名称: 2-[4-[2-[[2-[3-[2-azanyl-5-(cyclopropylmethoxy)-3,3-dimethyl-indol-6-yl]oxypropyl]-1,3-dihydroisoindol-5-yl]oxy]ethyl]-1,2,3-triazol-1-yl]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone, DIMETHYL SULFOXIDE, GLYCINE, ... 著者 Johansson, C, Fagan, V, Brennan, P.E, Sorrell, F.J, Krojer, T, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. 登録日 2018-11-19 公開日 2018-12-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62, 2019
2VNF	MOLECULAR BASIS OF HISTONE H3K4ME3 RECOGNITION BY ING4 分子名称: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, HISTONE H3, ... 著者 Palacios, A, Munoz, I.G, Pantoja-Uceda, D, Marcaida, M.J, Torres, D, Martin-Garcia, J.M, Luque, I, Montoya, G, Blanco, F.J. 登録日 2008-02-04 公開日 2008-04-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Molecular Basis of Histone H3K4Me3 Recognition by Ing4 J.Biol.Chem., 283, 2008
5Y21	Crystal structure of AL2 PAL domain in complex with AtRing1a proximal site 分子名称: AtRing1a proximal binding site peptide, PHD finger protein ALFIN-LIKE 2 著者 Peng, L, Wang, L.L, Huang, Y. 登録日 2017-07-22 公開日 2018-07-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.769 Å) 主引用文献 Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch J. Mol. Biol., 430, 2018
4UF0	Crystal structure of JmjC domain of human histone demethylase UTY in complex with epitherapuetic compound 2-(((2-((2-(dimethylamino)ethyl) (ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid. 分子名称: 1,2-ETHANEDIOL, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, FE (II) ION, ... 著者 Srikannathasan, V, Johansson, C, Gileadi, C, Tobias, K, Kopec, J, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U. 登録日 2014-12-22 公開日 2015-01-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016

<12345678910>