PDB: 507 件ウェブページステータス検索Chemie searchBIRD

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4EU1	Structure of a mitochondrial aspartate aminotransferase from Trypanosoma brucei 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Mitochondrial aspartate aminotransferase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-04-25 公開日 2012-05-16 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia. Acta Crystallogr F Struct Biol Commun, 71, 2015
2QB3	Structural Studies Reveal the Inactivation of E. coli L-Aspartate Aminotransferase by (s)-4,5-dihydro-2-thiophenecarboxylic acid (SADTA) via Two Mechanisms (at pH 7.5) 分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, Aspartate aminotransferase, ... 著者 Liu, D, Pozharski, E, Lepore, B, Fu, M, Silverman, R.B, Petsko, G.A, Ringe, D. 登録日 2007-06-15 公開日 2007-12-04 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms". Biochemistry, 46, 2007
4F5J	Rational Design and Directed Evolution for Conversion of Substrate Specificity from E.coli Aspartate Aminotransferase to Tyrosine Aminotransferase: Mutant P5. 分子名称: Aspartate aminotransferase 著者 Addington, T.A, Fisher, A.J, Toney, M.D. 登録日 2012-05-13 公開日 2013-02-13 最終更新日 2013-04-24 実験手法 X-RAY DIFFRACTION (1.954 Å) 主引用文献 Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J.Mol.Biol., 425, 2013
4F5F	Structure of Aspartate Aminotransferase Conversion to Tyrosine Aminotransferase: Chimera P1. 分子名称: Aspartate aminotransferase 著者 Addington, T.A, Fisher, A.J, Toney, M.D. 登録日 2012-05-13 公開日 2013-02-13 最終更新日 2013-04-24 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J.Mol.Biol., 425, 2013
4F5M	Wild-Type E. coli Aspartate Aminotransferase: A Template For The Interconversion of Substrate Specificity and Activity To Tyrosine Aminotransferase By The JANUS Algorithm. 分子名称: 1,2-ETHANEDIOL, Aspartate aminotransferase 著者 Addington, T.A, Fisher, A.J, Toney, M.D. 登録日 2012-05-13 公開日 2013-02-13 最終更新日 2013-04-24 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J.Mol.Biol., 425, 2013
2QBT	Structural Studies Reveal The Inactivation of E. coli L-aspartate aminotransferase by (S)-4,5-amino-dihydro-2-thiophenecarboxylic acid (SADTA) via Two Mechanisms (at pH 8.0) 分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, Aspartate aminotransferase, ... 著者 Liu, D, Pozharski, E, Lepore, B, Fu, M, Silverman, R.B, Petsko, G.A, Ringe, D. 登録日 2007-06-18 公開日 2007-09-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Inactivation of Escherichia coli l-Aspartate Aminotransferase by (S)-4-Amino-4,5-dihydro-2-thiophenecarboxylic Acid Reveals "A Tale of Two Mechanisms". Biochemistry, 46, 2007
4F5I	Substrate Specificity Conversion of E. coli Pyridoxal-5'-Phosphate Dependent Aspartate Aminotransferase to Tyrosine Aminotransferase: Chimera P4. 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Aspartate aminotransferase 著者 Addington, T.A, Fisher, A.J, Toney, M.D. 登録日 2012-05-13 公開日 2013-02-13 最終更新日 2013-04-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J.Mol.Biol., 425, 2013
1QIS	ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI, C191F MUTATION, WITH BOUND MALEATE 分子名称: ASPARTATE AMINOTRANSFERASE, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE 著者 Jeffery, C.J, Gloss, L.M, Petsko, G.A, Ringe, D. 登録日 1999-06-15 公開日 2000-06-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Role of Residues Outside the Active Site in Catalysis: Structural Basis for Function of C191 Mutants of E. Coli Aspartate Aminotransferase Protein Eng., 13, 2000
4F5H	Intercoversion of Substrate Specificity: E. coli Aspatate Aminotransferase to Tyrosine Aminotransferase: Chimera P3. 分子名称: Aspartate aminotransferase 著者 Addington, T.A, Fisher, A.J, Toney, M.D. 登録日 2012-05-13 公開日 2013-02-13 最終更新日 2013-04-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J.Mol.Biol., 425, 2013
4F5L	A Theoretical Optimized Mutant for the Conversion of Substrate Specificity and Activity of Aspartate Aminotransferase to Tyrosine Aminotransferase: Chimera P7. 分子名称: 1,2-ETHANEDIOL, Aspartate aminotransferase 著者 Addington, T.A, Fisher, A.J, Toney, M.D. 登録日 2012-05-13 公開日 2013-05-15 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Janus: an algorithm for ranking functional importance of residues from protein sequence alignments. To be Published
8E9N	Crystal structure of E. coli aspartate aminotransferase mutant VFIY in the ligand-free form at 278 K 分子名称: Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
8E9M	Crystal structure of E. coli aspartate aminotransferase mutant VFIT bound to maleic acid at 278 K 分子名称: Aspartate aminotransferase, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
1QIT	ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI, C191W MUTATION, WITH BOUND MALEATE 分子名称: ASPARTATE AMINOTRANSFERASE, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE 著者 Jeffery, C.J, Gloss, L.M, Petsko, G.A, Ringe, D. 登録日 1999-06-15 公開日 2000-06-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Role of Residues Outside the Active Site in Catalysis: Structural Basis for Function of C191 Mutants of E. Coli Aspartate Aminotransferase Protein Eng., 13, 2000
8E9R	Crystal structure of E. coli aspartate aminotransferase mutant VFCS in the ligand-free form at 278 K 分子名称: Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
8E9L	Crystal structure of E. coli aspartate aminotransferase mutant VFIT in the ligand-free form at 278 K 分子名称: Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
8E9O	Crystal structure of E. coli aspartate aminotransferase mutant VFIY bound to maleic acid at 278 K 分子名称: Aspartate aminotransferase, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
8E9K	Crystal structure of wild-type E. coli aspartate aminotransferase bound to maleate at 278 K 分子名称: Aspartate aminotransferase, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
8E9T	Crystal structure of wild-type E. coli aspartate aminotransferase in the ligand-free form at 303 K 分子名称: Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
8E9Q	Crystal structure of E. coli aspartate aminotransferase mutant HEX bound to maleic acid at 278 K 分子名称: Aspartate aminotransferase, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
8E9S	Crystal structure of E. coli aspartate aminotransferase mutant VFCS bound to maleic acid at 278 K 分子名称: Aspartate aminotransferase, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
8E9V	Crystal structure of E. coli aspartate aminotransferase mutant VFIT in the ligand-free form at 303 K 分子名称: Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
8E9P	Crystal structure of wild-type E. coli aspartate aminotransferase in the ligand-free form at 278 K 分子名称: Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-11-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
8E9J	Crystal structure of E. coli aspartate aminotransferase mutant HEX in the ligand-free form at 278 K 分子名称: Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-11-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
8E9D	Crystal structure of E. coli aspartate aminotransferase mutant AIFS bound to maleic acid at 100 K 分子名称: Aspartate aminotransferase, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-11-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023
8E9C	Crystal structure of E. coli aspartate aminotransferase mutant AIFS in the ligand-free form at 100 K 分子名称: Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION 著者 Chica, R.A, St-Jacques, A.D, Rodriguez, J.M, Thompson, M.C. 登録日 2022-08-26 公開日 2022-11-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity. Nat Commun, 14, 2023

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