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PDB: 1 results
5W8V
HUMAN HGPRT in complex with [(2-[(guanin-9-yl)methyl]propane-1,3-diyl)bis(oxy)]bis(methylene)diphosphonic acid
Descriptor:
Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, {[(2R)-2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-3-(2-phosphonoethoxy)propoxy]methyl}phosphonic acid
Authors:
Guddat, L.W
,
Keough, D.T.
Deposit date:
2017-06-22
Release date:
2017-08-30
Last modified:
2024-03-13
Method:
X-RAY DIFFRACTION (2.346 Å)
Cite:
Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.
J. Med. Chem., 60, 2017
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数据于2024-05-22公开中