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7CBX
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BU of 7cbx by Molmil
Crystal structure of MAP2K7 complexed with a covalent inhibitor 12
Descriptor: 3-(1H-indazol-3-yl)-5-(prop-2-enoylamino)-N-prop-2-ynyl-benzamide, Dual specificity mitogen-activated protein kinase kinase 7, GLYCEROL
Authors:Kinoshita, T, Murakawa, Y.
Deposit date:2020-06-15
Release date:2020-09-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.061 Å)
Cite:Structural basis for producing selective MAP2K7 inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
2ZDU
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BU of 2zdu by Molmil
Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor
Descriptor: 4-[(4-{[6-bromo-3-(methoxycarbonyl)-1-oxo-4-phenylisoquinolin-2(1H)-yl]methyl}phenyl)amino]-4-oxobutanoic acid, Mitogen-activated protein kinase 10
Authors:Sogabe, S, Ohra, T, Itoh, F, Habuka, N, Fujishima, A.
Deposit date:2007-11-27
Release date:2008-09-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1)
Bioorg.Med.Chem., 16, 2008
2ZV6
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BU of 2zv6 by Molmil
Crystal structure of human squamous cell carcinoma antigen 1
Descriptor: Serpin B3
Authors:Zheng, B, Matoba, Y, Katagiri, C, Hibino, T, Sugiyama, M.
Deposit date:2008-11-01
Release date:2009-02-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of SCCA1 and insight about the interaction with JNK1
Biochem.Biophys.Res.Commun., 380, 2009
7D9M
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BU of 7d9m by Molmil
grass carp interleukin-2
Descriptor: Interleukin
Authors:Junya, w, Jun, z.
Deposit date:2020-10-13
Release date:2020-10-28
Last modified:2020-11-11
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural insights into the co-evolution of IL-2 and its private receptor in fish.
Dev.Comp.Immunol., 115, 2020
1BZW
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BU of 1bzw by Molmil
PEANUT LECTIN COMPLEXED WITH C-LACTOSE
Descriptor: CALCIUM ION, MANGANESE (II) ION, PROTEIN (PEANUT LECTIN), ...
Authors:Ravishankar, R, Surolia, A, Vijayan, M, Lim, S, Kishi, Y.
Deposit date:1998-11-05
Release date:1998-11-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Preferred Conformation of C-Lactose at the Free and Peanut Lectin Bound States
J.Am.Chem.Soc., 120, 1998
4E73
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BU of 4e73 by Molmil
Crystal structure of JNK1beta-JIP in complex with an azaquinolone inhbitor
Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, methyl 3-(4-{[(1R,2S,3S,5S,7s)-5-aminotricyclo[3.3.1.1~3,7~]dec-2-yl]carbamoyl}benzyl)-4-oxo-1-phenyl-1,4-dihydro-1,8-naphthyridine-2-carboxylate
Authors:Lukacs, C.M, Janson, C.A.
Deposit date:2012-03-16
Release date:2013-05-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor.
ACS Med Chem Lett, 3, 2012
3O17
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BU of 3o17 by Molmil
Crystal Structure of JNK1-alpha1 isoform
Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, JIP1, 10MER PEPTIDE, ...
Authors:Abad-Zapatero, C.
Deposit date:2010-07-20
Release date:2011-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of JNK1-alpha1 isoform
TO BE PUBLISHED
3E7O
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BU of 3e7o by Molmil
Crystal Structure of JNK2
Descriptor: Mitogen-activated protein kinase 9, N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide
Authors:Kuglstatter, A, Villasenor, A.G.
Deposit date:2008-08-18
Release date:2008-09-09
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity.
J.Mol.Biol., 383, 2008
3FAU
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BU of 3fau by Molmil
Crystal Structure of human small-MutS related domain
Descriptor: NEDD4-binding protein 2
Authors:Kim, T.G, Kwon, T.H, Ryu, E.K, Min, K, Heo, S.-D, Song, K.M, Jun, W.J, Jung, E.
Deposit date:2008-11-18
Release date:2009-12-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Strcutral Dynamincs of the Endonuclease Small-MutS Related Domains of BCL3 binding protein
To be Published
7UCD
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BU of 7ucd by Molmil
Transcription factor FosB/JunD bZIP domain covalently modified with the cysteine-targeting alpha-haloketone compound Z2159931480
Descriptor: 7-acetyl-4-methoxy-1-benzofuran-3(2H)-one, CHLORIDE ION, Protein fosB, ...
Authors:Kumar, A, Machius, M.C, Rudenko, G.
Deposit date:2022-03-16
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Chemically targeting the redox switch in AP1 transcription factor Delta FOSB.
Nucleic Acids Res., 50, 2022
8G2O
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BU of 8g2o by Molmil
Fab structure - Anti-ApoE-7C11 antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, anti-ApoE-7C11 heavy chain, anti-ApoE-7C11 light chain
Authors:Marino, C, Arboleda-Velasquez, J.F.
Deposit date:2023-02-06
Release date:2023-10-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation.
Alzheimers Dement, 20, 2024
6EJN
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BU of 6ejn by Molmil
The KLC2 TPR domain bound to the JIP3 leucine zipper domain
Descriptor: C-Jun-amino-terminal kinase-interacting protein 3, Kinesin light chain 2
Authors:Cockburn, J, Hesketh, S.J, Way, M.
Deposit date:2017-09-22
Release date:2018-09-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3.
Structure, 26, 2018
4PXJ
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BU of 4pxj by Molmil
Crystallographic structure of the LZII fragment (anti-parallel orientation) from JIP3
Descriptor: 1,2-ETHANEDIOL, C-Jun-amino-terminal kinase-interacting protein 3, GUANIDINE, ...
Authors:Llinas, P, Menetrey, J.
Deposit date:2014-03-24
Release date:2015-06-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structure of a truncated form of leucine zipper II of JIP3 reveals an unexpected antiparallel coiled-coil arrangement.
Acta Crystallogr F Struct Biol Commun, 72, 2016
6FUZ
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BU of 6fuz by Molmil
Crystal structure of the TPR domain of KLC1 in complex with the C-terminal peptide of JIP1
Descriptor: GLYCEROL, Kinesin light chain 1,Kinesin light chain 1,C-Jun-amino-terminal kinase-interacting protein 1, nanobody
Authors:Pernigo, S, Dodding, M.P, Steiner, R.A.
Deposit date:2018-02-28
Release date:2018-05-02
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors.
Elife, 7, 2018
3V6R
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BU of 3v6r by Molmil
Discovery of potent and selective covalent inhibitors of JNK
Descriptor: 4-{[4-(dimethylamino)butanoyl]amino}-N-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide, Mitogen-activated protein kinase 10
Authors:Park, H, LoGrasso, P.V, Laughlin, J.D.
Deposit date:2011-12-20
Release date:2012-02-01
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of potent and selective covalent inhibitors of JNK.
Chem.Biol., 19, 2012
3V6S
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BU of 3v6s by Molmil
Discovery of potent and selective covalent inhibitors of JNK
Descriptor: 3-{[4-(dimethylamino)butanoyl]amino}-N-(4-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide, Mitogen-activated protein kinase 10
Authors:Park, H, Laughlin, J.D, LoGrasso, P.V.
Deposit date:2011-12-20
Release date:2012-02-01
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Discovery of potent and selective covalent inhibitors of JNK.
Chem.Biol., 19, 2012
8PTK
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BU of 8ptk by Molmil
Composite structure of Dynein-Dynactin-JIP3-LIS1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ...
Authors:Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P.
Deposit date:2023-07-14
Release date:2024-03-27
Last modified:2024-04-10
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Science, 383, 2024
8PR4
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BU of 8pr4 by Molmil
Dynactin pointed end bound to JIP3
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Arp11, C-Jun-amino-terminal kinase-interacting protein 3, ...
Authors:Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P.
Deposit date:2023-07-12
Release date:2024-03-27
Last modified:2024-04-10
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Science, 383, 2024
8PR2
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BU of 8pr2 by Molmil
Cytoplasmic dynein-1 heavy chain bound to JIP3-LZI
Descriptor: C-Jun-amino-terminal kinase-interacting protein 3, Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, ...
Authors:Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P.
Deposit date:2023-07-12
Release date:2024-03-27
Last modified:2024-04-10
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Science, 383, 2024
8PR3
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BU of 8pr3 by Molmil
Cytoplasmic dynein-1 heavy chain bound to JIP3-RH1
Descriptor: C-Jun-amino-terminal kinase-interacting protein 3, Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, ...
Authors:Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P.
Deposit date:2023-07-12
Release date:2024-03-27
Last modified:2024-04-10
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Science, 383, 2024
4G1W
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BU of 4g1w by Molmil
Crystal structure of JNK1 in complex with JIP1 peptide and 7-Fluoro-3-[4-(2-hydroxy-ethanesulfonyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester
Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, methyl 7-fluoro-3-{4-[(2-hydroxyethyl)sulfonyl]benzyl}-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylate
Authors:Kuglstatter, A, Shao, A.
Deposit date:2012-07-11
Release date:2013-07-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of JNK1 in complex with JIP1 peptide and inhibitor
To be Published
4H36
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BU of 4h36 by Molmil
Crystal Structure of JNK3 in Complex with ATF2 Peptide
Descriptor: Cyclic AMP-dependent transcription factor ATF-2, Mitogen-activated protein kinase 10
Authors:Nwachukwu, J.C, Laughlin, J.D, Figuera-Losada, M, Cherry, L, Nettles, K.W, LoGrasso, P.V.
Deposit date:2012-09-13
Release date:2012-11-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases.
Structure, 20, 2012
4H3B
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BU of 4h3b by Molmil
Crystal Structure of JNK3 in Complex with SAB Peptide
Descriptor: Mitogen-activated protein kinase 10, SH3 domain-binding protein 5
Authors:Nwachukwu, J.C, Laughlin, J.D, Figuera-Losada, M, Cherry, L, Nettles, K.W, LoGrasso, P.V.
Deposit date:2012-09-13
Release date:2012-11-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases.
Structure, 20, 2012
5K4C
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BU of 5k4c by Molmil
Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 2
Descriptor: Eukaryotic translation initiation factor 3 subunit D, GLYCEROL
Authors:Kranzusch, P.J, Lee, A.S.Y, Doudna, J.A, Cate, J.H.D.
Deposit date:2016-05-20
Release date:2016-07-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature, 536, 2016
5K4B
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BU of 5k4b by Molmil
Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 1
Descriptor: CHLORIDE ION, Eukaryotic translation initiation factor 3 subunit D
Authors:Kranzusch, P.J, Lee, A.S.Y, Doudna, J.A, Cate, J.H.D.
Deposit date:2016-05-20
Release date:2016-07-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature, 536, 2016

221051

數據於2024-06-12公開中

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