9B6I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b6i by Molmil](/molmil-images/mine/9b6i) | Cryo-EM structure of the avian great tit TRPM8 channel in complex with the antagonist TC-I 2014 | Descriptor: | 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
|
|
9B6H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b6h by Molmil](/molmil-images/mine/9b6h) | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 and the cooling agonist C3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
|
|
9B6G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b6g by Molmil](/molmil-images/mine/9b6g) | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMTB | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide, ... | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
|
|
9B6F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b6f by Molmil](/molmil-images/mine/9b6f) | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMG2850 | Descriptor: | (8R)-8-[4-(trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-5,8-dihydro-1,7-naphthyridine-7(6H)-carboxamide, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
|
|
9B6E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b6e by Molmil](/molmil-images/mine/9b6e) | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 | Descriptor: | 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
|
|
9B6D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b6d by Molmil](/molmil-images/mine/9b6d) | Cryo-EM structure of the mouse TRPM8 channel in the ligand-free desensitized state | Descriptor: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
|
|
9B6A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b6a by Molmil](/molmil-images/mine/9b6a) | |
9B69
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b69 by Molmil](/molmil-images/mine/9b69) | GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of NTD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Flip of Glutamate receptor 2, ... | Authors: | Nakagawa, T, Greger, I.H. | Deposit date: | 2024-03-23 | Release date: | 2024-07-31 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
|
|
9B68
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b68 by Molmil](/molmil-images/mine/9b68) | GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of NTD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Flip of Glutamate receptor 2, ... | Authors: | Nakagawa, T, Greger, I.H. | Deposit date: | 2024-03-23 | Release date: | 2024-07-31 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
|
|
9B67
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b67 by Molmil](/molmil-images/mine/9b67) | |
9B64
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b64 by Molmil](/molmil-images/mine/9b64) | |
9B63
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b63 by Molmil](/molmil-images/mine/9b63) | |
9B61
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b61 by Molmil](/molmil-images/mine/9b61) | |
9B60
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b60 by Molmil](/molmil-images/mine/9b60) | |
9B5Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b5z by Molmil](/molmil-images/mine/9b5z) | |
9B5X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b5x by Molmil](/molmil-images/mine/9b5x) | |
9B5W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b5w by Molmil](/molmil-images/mine/9b5w) | |
9B5V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b5v by Molmil](/molmil-images/mine/9b5v) | |
9B5U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b5u by Molmil](/molmil-images/mine/9b5u) | |
9B5T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b5t by Molmil](/molmil-images/mine/9b5t) | |
9B5S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b5s by Molmil](/molmil-images/mine/9b5s) | |
9B5R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b5r by Molmil](/molmil-images/mine/9b5r) | |
9B5Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b5q by Molmil](/molmil-images/mine/9b5q) | |
9B5P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b5p by Molmil](/molmil-images/mine/9b5p) | |
9B5O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9b5o by Molmil](/molmil-images/mine/9b5o) | |