Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6NZR
DownloadVisualize
BU of 6nzr by Molmil
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_12 AKA 4-[(2-methanesulfonylphenyl)amino]-N-(H3)methyl-6-[(pyridin-2- yl)amino]pyridazine-3-carboxamide
Descriptor: N-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2, SULFATE ION
Authors:Khan, J.A.
Deposit date:2019-02-14
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
J.Med.Chem., 62, 2019
6RPU
DownloadVisualize
BU of 6rpu by Molmil
Structure of the ternary complex of the IMPDH enzyme from Ashbya gossypii bound to the dinucleoside polyphosphate Ap5G and GDP
Descriptor: ACETATE ION, GUANOSINE-5'-DIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, ...
Authors:Buey, R.M, Fernandez-Justel, D, Revuelta, J.L.
Deposit date:2019-05-14
Release date:2019-08-28
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates.
J.Biol.Chem., 294, 2019
7NMS
DownloadVisualize
BU of 7nms by Molmil
InlB392_T332E: T332E variant of Listeria monocytogenes InlB (internalin B) residues 36-392
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Internalin B, ...
Authors:Geerds, C, Niemann, H.H.
Deposit date:2021-02-23
Release date:2022-01-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A recurring packing contact in crystals of InlB pinpoints functional binding sites in the internalin domain and the B repeat.
Acta Crystallogr D Struct Biol, 78, 2022
6SD0
DownloadVisualize
BU of 6sd0 by Molmil
Structure of beta-galactosidase from Thermotoga maritima.
Descriptor: Beta-galactosidase, MAGNESIUM ION
Authors:Jimenez-Ortega, E, Ramirez-Escudero, M, Sanz-Aparicio, J.
Deposit date:2019-07-26
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:The cryo-EM Structure ofThermotoga maritimabeta-Galactosidase: Quaternary Structure Guides Protein Engineering.
Acs Chem.Biol., 15, 2020
3MQ2
DownloadVisualize
BU of 3mq2 by Molmil
Crystal Structure of 16S rRNA Methyltranferase KamB
Descriptor: 16S rRNA methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Macmaster, R.A.
Deposit date:2010-04-27
Release date:2010-12-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria.
Nucleic Acids Res., 38, 2010
1Z7N
DownloadVisualize
BU of 1z7n by Molmil
ATP Phosphoribosyl transferase (HisZG ATP-PRTase) from Lactococcus lactis with bound PRPP substrate
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, ATP phosphoribosyltransferase, ATP phosphoribosyltransferase regulatory subunit, ...
Authors:Champagne, K.S, Sissler, M, Larrabee, Y, Doublie, S, Francklyn, C.S.
Deposit date:2005-03-25
Release date:2005-08-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog.
J.Biol.Chem., 280, 2005
8ARH
DownloadVisualize
BU of 8arh by Molmil
In situ subtomogram average of Vaccinia virus (WR) D13 lattice, on immature virions
Descriptor: Scaffold protein D13
Authors:Calcraft, T, Hernandez-Gonzalez, M, Nans, A, Rosenthal, P.B, Way, M.
Deposit date:2022-08-16
Release date:2023-02-01
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (19.200001 Å)
Cite:A succession of two viral lattices drives vaccinia virus assembly.
Plos Biol., 21, 2023
6T7O
DownloadVisualize
BU of 6t7o by Molmil
X-ray structure of the C-terminal domain of S. aureus Hibernating Promoting Factor (CTD-SaHPF)
Descriptor: Ribosome hibernation promotion factor
Authors:Fatkhullin, B.F, Khusainov, I.S, Ayupov, R.K, Gabdulkhakov, A.G, Tishchenko, S.V, Validov, S.Z, Yusupov, M.M.
Deposit date:2019-10-22
Release date:2019-12-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.60003626 Å)
Cite:Dimerization of long hibernation promoting factor from Staphylococcus aureus: Structural analysis and biochemical characterization.
J.Struct.Biol., 209, 2020
1Z7M
DownloadVisualize
BU of 1z7m by Molmil
ATP Phosphoribosyl transferase (HisZG ATP-PRTase) from Lactococcus lactis
Descriptor: ATP phosphoribosyltransferase, ATP phosphoribosyltransferase regulatory subunit, PHOSPHATE ION, ...
Authors:Champagne, K.S, Sissler, M, Larrabee, Y, Doublie, S, Francklyn, C.S.
Deposit date:2005-03-25
Release date:2005-08-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog.
J.Biol.Chem., 280, 2005
2PWY
DownloadVisualize
BU of 2pwy by Molmil
Crystal Structure of a m1A58 tRNA methyltransferase
Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, tRNA (adenine-N(1)-)-methyltransferase
Authors:Barraud, P, Golinelli-Pimpaneau, B, Tisne, C.
Deposit date:2007-05-14
Release date:2008-02-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Thermus thermophilus tRNA m(1)A(58) Methyltransferase and Biophysical Characterization of Its Interaction with tRNA.
J.Mol.Biol., 377, 2008
1TC5
DownloadVisualize
BU of 1tc5 by Molmil
Structural Analysis of a probable eukaryotic D-amino acid tRNA deacylase
Descriptor: Probable eukaryotic D-amino acid tRNA deacylase, LMAJ005534AAA
Authors:Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-05-20
Release date:2004-06-08
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural analysis of LMAJ005534AAA, a probable eukaryotic D-amino acid tRNA deacylase from Leishmania major
To be Published
7OO5
DownloadVisualize
BU of 7oo5 by Molmil
Crystal structure of the lignin peroxidase (ApeLiP) from Agrocybe pediades
Descriptor: CALCIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ZINC ION, ...
Authors:Romero, A, Ruiz-Duenas, F.J.
Deposit date:2021-05-26
Release date:2021-10-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Agaricales Mushroom Lignin Peroxidase: From Structure-Function to Degradative Capabilities.
Antioxidants, 10, 2021
7UO6
DownloadVisualize
BU of 7uo6 by Molmil
NMR structure of Pheromone-binding protein 2 in Ostrinia furnacalis
Descriptor: Pheromone binding protein 2
Authors:Ayyappan, S, Mohanty, S.
Deposit date:2022-04-12
Release date:2023-02-15
Method:SOLUTION NMR
Cite:Ostrinia furnacalis PBP2 solution NMR structure: Insight into ligand binding and release mechanisms.
Protein Sci., 31, 2022
5C8F
DownloadVisualize
BU of 5c8f by Molmil
Crystal structure of light-exposed full-length Thermus thermophilus CarH bound to cobalamin
Descriptor: CHLORIDE ION, COBALAMIN, GLYCEROL, ...
Authors:Jost, M, Drennan, C.L.
Deposit date:2015-06-25
Release date:2015-09-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis for gene regulation by a B12-dependent photoreceptor.
Nature, 526, 2015
5C8A
DownloadVisualize
BU of 5c8a by Molmil
Crystal structure of a truncated form of Thermus thermophilus CarH bound to adenosylcobalamin (dark state)
Descriptor: 5'-DEOXYADENOSINE, COBALAMIN, GLYCEROL, ...
Authors:Jost, M, Drennan, C.L.
Deposit date:2015-06-25
Release date:2015-09-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for gene regulation by a B12-dependent photoreceptor.
Nature, 526, 2015
8A53
DownloadVisualize
BU of 8a53 by Molmil
Crystal structure of AtMCA-IIf C147A (metacaspase 9) from Arabidopsis thaliana
Descriptor: Metacaspase-9, NITRATE ION
Authors:Sabljic, I, Stael, S, Stahlberg, J, Bozhkov, P.
Deposit date:2022-06-14
Release date:2023-05-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-function study of a Ca 2+ -independent metacaspase involved in lateral root emergence.
Proc.Natl.Acad.Sci.USA, 120, 2023
5C8D
DownloadVisualize
BU of 5c8d by Molmil
Crystal structure of full-length Thermus thermophilus CarH bound to adenosylcobalamin (dark state)
Descriptor: 5'-DEOXYADENOSINE, COBALAMIN, Light-dependent transcriptional regulator CarH
Authors:Jost, M, Drennan, C.L.
Deposit date:2015-06-25
Release date:2015-09-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for gene regulation by a B12-dependent photoreceptor.
Nature, 526, 2015
7K7Q
DownloadVisualize
BU of 7k7q by Molmil
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-N-methylpyridazine-3-carboxamide
Descriptor: 6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-N-methylpyridazine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2
Authors:Khan, J.A.
Deposit date:2020-09-23
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
J.Med.Chem., 64, 2021
4ZYP
DownloadVisualize
BU of 4zyp by Molmil
Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein
Descriptor: AM14 antibody Fab heavy chain, AM14 antibody light chain, Fusion glycoprotein F0,Fibritin, ...
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2015-05-21
Release date:2015-07-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein.
Plos Pathog., 11, 2015
7K7O
DownloadVisualize
BU of 7k7o by Molmil
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide
Descriptor: 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2
Authors:Khan, J.A.
Deposit date:2020-09-23
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
J.Med.Chem., 64, 2021
5C8E
DownloadVisualize
BU of 5c8e by Molmil
Crystal structure of Thermus thermophilus CarH bound to adenosylcobalamin and a 26-bp DNA segment
Descriptor: 26-mer DNA segment containing the CarH operator sequence (antisense strand), 26-mer DNA segment containing the CarH operator sequence (sense strand), 5'-DEOXYADENOSINE, ...
Authors:Jost, M, Drennan, C.L.
Deposit date:2015-06-25
Release date:2015-09-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.89 Å)
Cite:Structural basis for gene regulation by a B12-dependent photoreceptor.
Nature, 526, 2015
1G5H
DownloadVisualize
BU of 1g5h by Molmil
CRYSTAL STRUCTURE OF THE ACCESSORY SUBUNIT OF MURINE MITOCHONDRIAL POLYMERASE GAMMA
Descriptor: GLYCEROL, MITOCHONDRIAL DNA POLYMERASE ACCESSORY SUBUNIT, SODIUM ION
Authors:Carrodeguas, J.A, Theis, K, Bogenhagen, D.F, Kisker, C.
Deposit date:2000-11-01
Release date:2001-03-14
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer.
Mol.Cell, 7, 2001
1G5I
DownloadVisualize
BU of 1g5i by Molmil
CRYSTAL STRUCTURE OF THE ACCESSORY SUBUNIT OF MURINE MITOCHONDRIAL POLYMERASE GAMMA
Descriptor: GLYCEROL, MITOCHONDRIAL DNA POLYMERASE ACCESSORY SUBUNIT, SODIUM ION
Authors:Carrodeguas, J.A, Theis, K, Bogenhagen, D.F, Kisker, C.
Deposit date:2000-11-01
Release date:2001-03-14
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer.
Mol.Cell, 7, 2001
4ZYK
DownloadVisualize
BU of 4zyk by Molmil
Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, AM14 Fab heavy chain, ...
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2015-05-21
Release date:2015-07-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein.
Plos Pathog., 11, 2015
8BG1
DownloadVisualize
BU of 8bg1 by Molmil
Crystal structure of the SARS-CoV-2 S RBD in complex with pT1511 scFV
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Hansen, G, Ssebyatika, G.L, Krey, T.
Deposit date:2022-10-27
Release date:2023-11-08
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses?
To be published

222415

數據於2024-07-10公開中

PDB statisticsPDBj update infoContact PDBjnumon