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7LYK	South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the 2-RBD-up conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-07 Release date: 2021-03-31 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (3.65 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LYQ	South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the 1-RBD-up conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-07 Release date: 2021-03-31 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (3.34 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LWW	Triple mutant (K417N-E484K-N501Y) SARS-CoV-2 spike protein in the 1-RBD-up conformation (S-GSAS-D614G-K417N-E484K-N501Y) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-01 Release date: 2021-03-31 Last modified: 2021-08-18 Method: ELECTRON MICROSCOPY (3 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LWO	Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 1-RBD up conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-01 Release date: 2021-03-31 Last modified: 2021-08-18 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LYL	South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the RBD-down conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-07 Release date: 2021-03-31 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (3.72 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LYM	South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the RBD-down conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-07 Release date: 2021-03-31 Last modified: 2021-08-18 Method: ELECTRON MICROSCOPY (3.57 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LWK	Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 3-RBD down conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-01 Release date: 2021-03-31 Last modified: 2021-08-18 Method: ELECTRON MICROSCOPY (2.92 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LYO	South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the 1-RBD-up conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-07 Release date: 2021-03-31 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (3.32 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LWT	UK (B.1.1.7) SARS-CoV-2 spike protein variant (S-GSAS-B.1.1.7) in the 1-RBD-up conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-01 Release date: 2021-03-31 Last modified: 2021-08-18 Method: ELECTRON MICROSCOPY (3.19 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LWP	Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 2-RBD up conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-01 Release date: 2021-03-31 Last modified: 2021-08-18 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LYP	South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the 1-RBD-up conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-07 Release date: 2021-03-31 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (4.05 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LWU	UK (B.1.1.7) SARS-CoV-2 spike protein variant (S-GSAS-B.1.1.7) in the 1-RBD-up conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-01 Release date: 2021-03-31 Last modified: 2021-08-18 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LYN	South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the 1-RBD-up conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-07 Release date: 2021-03-31 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (3.32 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LWV	UK (B.1.1.7) SARS-CoV-2 spike protein variant (S-GSAS-B.1.1.7) in the 1-RBD-up conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-01 Release date: 2021-03-31 Last modified: 2021-08-18 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LWN	Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 1-RBD up conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-01 Release date: 2021-03-31 Last modified: 2021-08-18 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LWQ	Mink Cluster 5-associated SARS-CoV-2 spike protein(S-GSAS-D614G-delFV) missing the S1 subunit and SD2 subdomain of one protomer Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-01 Release date: 2021-03-31 Last modified: 2021-08-18 Method: ELECTRON MICROSCOPY (3.44 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7LWL	Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 3-RBD down conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Gobeil, S, Acharya, P. Deposit date: 2021-03-01 Release date: 2021-03-31 Last modified: 2021-08-18 Method: ELECTRON MICROSCOPY (2.84 Å) Cite: Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021
7KJP	Disulfide Stabilized Norovirus GI.1 VLP Shell Region Descriptor: Capsid protein VP1 Authors: Gorman, J, Kwong, P.D. Deposit date: 2020-10-26 Release date: 2020-12-02 Last modified: 2020-12-30 Method: ELECTRON MICROSCOPY (3.86 Å) Cite: Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes. NPJ Vaccines, 5, 2020
7K7A	Transmembrane structure of TNFR1 Descriptor: Tumor necrosis factor receptor superfamily member 1A Authors: Zhao, L, Chou, J. Deposit date: 2020-09-22 Release date: 2020-09-30 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: The Diversity and Similarity of Transmembrane Trimerization of TNF Receptors. Front Cell Dev Biol, 8, 2020
7KNI	Cryo-EM structure of Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 5.5 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L. Deposit date: 2020-11-04 Release date: 2020-12-16 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (3.91 Å) Cite: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
7KNE	Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 5.5 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L. Deposit date: 2020-11-04 Release date: 2020-12-16 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (3.85 Å) Cite: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
7KNB	Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 7.4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Gorman, J, Kwong, P.D, Shapiro, L. Deposit date: 2020-11-04 Release date: 2020-12-09 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (3.93 Å) Cite: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
7KMS	Cryo-EM structure of triple ACE2-bound SARS-CoV-2 trimer spike at pH 7.4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Gorman, J, Kwong, P.D, Shapiro, L. Deposit date: 2020-11-03 Release date: 2020-12-09 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (3.64 Å) Cite: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
7KMZ	Cryo-EM structure of double ACE2-bound SARS-CoV-2 trimer Spike at pH 7.4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Gorman, J, Kwong, P.D, Shapiro, L. Deposit date: 2020-11-03 Release date: 2020-12-09 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (3.62 Å) Cite: Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
7JRA	HUMAN TNF-ALPHA IN COMPLEX WITH 2-[5-(3-chloro-4-{[(1R)-1-(2-fluorophenyl)ethyl]amino}quinolin-6-yl)pyrimidin-2-yl]propan-2-ol Descriptor: 2-[5-(3-chloro-4-{[(1R)-1-(2-fluorophenyl)ethyl]amino}quinolin-6-yl)pyrimidin-2-yl]propan-2-ol, GLYCEROL, Tumor necrosis factor Authors: Sheriff, S. Deposit date: 2020-08-11 Release date: 2020-12-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNF alpha Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches. J.Med.Chem., 63, 2020

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