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1L09	CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Dao-Pin, S, Bell, J, Alber, T, Matthews, B.W. Deposit date: 1988-02-05 Release date: 1988-04-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature, 330, 1987
1L26	REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY Descriptor: BETA-MERCAPTOETHANOL, T4 LYSOZYME Authors: Bell, J.A, Dao-Pin, S, Matthews, B.W. Deposit date: 1989-05-01 Release date: 1990-01-15 Last modified: 2022-11-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability. Science, 239, 1988
1L44	CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY Descriptor: T4 LYSOZYME Authors: Daopin, S, Matthews, B.W. Deposit date: 1991-01-28 Release date: 1991-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. J.Mol.Biol., 221, 1991
1L58	ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, T4 LYSOZYME Authors: Nicholson, H, Matthews, B.W. Deposit date: 1991-05-06 Release date: 1991-10-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.65 Å) Cite: To be Published
1CX7	T4 LYSOZYME METHIONINE CORE MUTANT Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Baase, W.A, Lindstrom, J, Lu, J, Matthews, B.W. Deposit date: 1999-08-28 Release date: 1999-11-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Use of differentially substituted selenomethionine proteins in X-ray structure determination. Acta Crystallogr.,Sect.D, 55, 1999
1L64	TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Heinz, D, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence. Proc.Natl.Acad.Sci.USA, 89, 1992
1L71	MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Zhang, X, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992
1L76	TOLERANCE OF T4 LYSOZYME TO PROLINE SUBSTITUTIONS WITHIN THE LONG INTERDOMAIN ALPHA-HELIX ILLUSTRATES THE ADAPTABILITY OF PROTEINS TO POTENTIALLY DESTABILIZING LESIONS Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Sauer, U, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions. J.Biol.Chem., 267, 1992
1L91	SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Eriksson, A.E, Matthews, B.W. Deposit date: 1992-01-21 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J.Mol.Biol., 229, 1993
1L96	STRUCTURE OF A HINGE-BENDING BACTERIOPHAGE T4 LYSOZYME MUTANT, ILE3-> PRO Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Dixon, M, Shewchuk, L, Matthews, B.W. Deposit date: 1992-02-11 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of a hinge-bending bacteriophage T4 lysozyme mutant, Ile3-->Pro. J.Mol.Biol., 227, 1992
1LGW	T4 Lysozyme Mutant L99A/M102Q Bound by 2-fluoroaniline Descriptor: 2-FLUOROANILINE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... Authors: Wei, B.Q, Baase, W.A, Weaver, L.H, Matthews, B.W, Shoichet, B.K. Deposit date: 2002-04-16 Release date: 2002-05-08 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.85 Å) Cite: A Model Binding Site for Testing Scoring Functions in Molecular Docking J.Mol.Biol., 322, 2002
1L87	SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Eriksson, A.E, Matthews, B.W. Deposit date: 1992-01-21 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J.Mol.Biol., 229, 1993
1CU6	T4 LYSOZYME MUTANT L91A Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Baase, W.A, Lindstrom, J.D, Lu, J, Matthews, B.W. Deposit date: 1999-08-20 Release date: 1999-11-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding. Biochemistry, 38, 1999
1CV3	T4 LYSOZYME MUTANT L121M Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Baase, W.A, Lindstrom, J, Lu, J, Matthews, B.W. Deposit date: 1999-08-22 Release date: 1999-08-24 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding. Biochemistry, 38, 1999
1L30	REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY Descriptor: T4 LYSOZYME Authors: Bell, J.A, Dao-Pin, S, Matthews, B.W. Deposit date: 1989-05-01 Release date: 1990-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability. Science, 239, 1988
1L36	TOWARD A SIMPLIFICATION OF THE PROTEIN FOLDING PROBLEM: A STABILIZING POLYALANINE ALPHA-HELIX ENGINEERED IN T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Zhang, X.-J, Baase, W.A, Matthews, B.W. Deposit date: 1990-12-26 Release date: 1991-10-15 Last modified: 2022-11-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in T4 lysozyme. Biochemistry, 30, 1991
1L63	ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Nicholson, H, Matthews, B.W. Deposit date: 1991-05-06 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme. Biochemistry, 30, 1991
1L52	STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Daopin, S, Matthews, B.W. Deposit date: 1991-01-28 Release date: 1991-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme. J.Mol.Biol., 221, 1991
1L80	DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Hurley, J.H, Matthews, B.W. Deposit date: 1991-11-12 Release date: 1993-04-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme. J.Mol.Biol., 224, 1992
1L89	SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Eriksson, A.E, Matthews, B.W. Deposit date: 1992-01-21 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J.Mol.Biol., 229, 1993
1L77	DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Hurley, J.H, Matthews, B.W. Deposit date: 1991-11-12 Release date: 1993-04-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme. J.Mol.Biol., 224, 1992
1L92	SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Eriksson, A.E, Matthews, B.W. Deposit date: 1992-01-21 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J.Mol.Biol., 229, 1993
1L97	STRUCTURE OF A HINGE-BENDING BACTERIOPHAGE T4 LYSOZYME MUTANT, ILE3-> PRO Descriptor: T4 LYSOZYME Authors: Dixon, M, Shewchuk, L, Matthews, B.W. Deposit date: 1992-02-11 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of a hinge-bending bacteriophage T4 lysozyme mutant, Ile3-->Pro. J.Mol.Biol., 227, 1992
1C6N	T4 LYSOZYME MUTANT C54T/C97A/L99A/F153A IN THE PRESENCE OF 8 ATM XENON Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, PROTEIN (LYSOZYME), ... Authors: Quillin, M.L, Matthews, B.W. Deposit date: 1999-12-21 Release date: 2000-10-04 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme. J.Mol.Biol., 302, 2000
1C66	T4 LYSOZYME MUTANT C54T/C97A/L121A/L133A IN THE PRESENCE OF 8 ATM ARGON Descriptor: ARGON, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... Authors: Quillin, M.L, Matthews, B.W. Deposit date: 1999-12-21 Release date: 2000-10-04 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme. J.Mol.Biol., 302, 2000

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