6PUD
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![BU of 6pud by Molmil](/molmil-images/mine/6pud) | Structure of human MAIT A-F7 TCR in complex with human MR1-5'OH-Pentyl-5-OP-U | Descriptor: | 6-[(5-hydroxypentyl)amino]-5-[(E)-propylideneamino]pyrimidine-2,4(1H,3H)-dione, Beta-2-microglobulin, Human TCR alpha chain, ... | Authors: | Awad, W, Rossjohn, J. | Deposit date: | 2019-07-18 | Release date: | 2020-02-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat.Immunol., 21, 2020
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2H26
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![BU of 2h26 by Molmil](/molmil-images/mine/2h26) | human CD1b in complex with endogenous phosphatidylcholine and spacer | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Garcia-Alles, L.F, Maveyraud, L, Vallina, A.T, Guillet, V, Mourey, L. | Deposit date: | 2006-05-18 | Release date: | 2006-07-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b. Embo J., 25, 2006
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1DQQ
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![BU of 1dqq by Molmil](/molmil-images/mine/1dqq) | CRYSTAL STRUCTURE OF ANTI-LYSOZYME ANTIBODY HYHEL-63 | Descriptor: | ANTI-LYSOZYME ANTIBODY HYHEL-63 (HEAVY CHAIN), ANTI-LYSOZYME ANTIBODY HYHEL-63 (LIGHT CHAIN) | Authors: | Li, H, Mariuzza, R.A. | Deposit date: | 2000-01-04 | Release date: | 2000-01-19 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Three-dimensional structures of the free and antigen-bound Fab from monoclonal antilysozyme antibody HyHEL-63(,). Biochemistry, 39, 2000
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3O3A
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![BU of 3o3a by Molmil](/molmil-images/mine/3o3a) | Human Class I MHC HLA-A2 in complex with the Peptidomimetic ELA-1 | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | Authors: | Borbulevych, O.Y, Baker, B.M. | Deposit date: | 2010-07-23 | Release date: | 2010-12-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of HLA-A*0201 complexed with Melan-A/MART-1(26(27L)-35) peptidomimetics reveal conformational heterogeneity and highlight degeneracy of T cell recognition. J.Med.Chem., 53, 2010
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6PUG
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![BU of 6pug by Molmil](/molmil-images/mine/6pug) | Structure of human MAIT A-F7 TCR in complex with human MR1-2`OH-Ethyl-5-OP-U | Descriptor: | 6-[(2-hydroxyethyl)amino]-5-[(E)-(2-oxopropylidene)amino]pyrimidine-2,4(1H,3H)-dione, Beta-2-microglobulin, CHLORIDE ION, ... | Authors: | Awad, W, Rossjohn, J. | Deposit date: | 2019-07-18 | Release date: | 2020-02-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat.Immunol., 21, 2020
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2WY3
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![BU of 2wy3 by Molmil](/molmil-images/mine/2wy3) | Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligands | Descriptor: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | Authors: | Mueller, S, Zocher, G, Steinle, A, Stehle, T. | Deposit date: | 2009-11-11 | Release date: | 2010-02-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of the Hcmv Ul16-Micb Complex Elucidates Select Binding of a Viral Immunoevasin to Diverse Nkg2D Ligands. Plos Pathog., 6, 2010
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5EFI
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![BU of 5efi by Molmil](/molmil-images/mine/5efi) | Crystal structure of mouse CD1d in complex with the p99p lipopeptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | Authors: | Girardi, E, Wang, J, Zajonc, D.M. | Deposit date: | 2015-10-23 | Release date: | 2016-03-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of an alpha-Helical Peptide and Lipopeptide Bound to the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule CD1d. J.Biol.Chem., 291, 2016
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1FZO
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![BU of 1fzo by Molmil](/molmil-images/mine/1fzo) | MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND SENDAI VIRUS NUCLEOPROTEIN | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Rudolph, M.G, Speir, J.A, Brunmark, A, Mattsson, N, Jackson, M.R, Peterson, P.A, Teyton, L, Wilson, I.A. | Deposit date: | 2000-10-03 | Release date: | 2001-03-28 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity. Immunity, 14, 2001
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2AXF
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![BU of 2axf by Molmil](/molmil-images/mine/2axf) | The Immunogenicity of a Viral Cytotoxic T Cell Epitope is controlled by its MHC-bound Conformation | Descriptor: | 10-mer peptide from BZLF1 trans-activator protein, ACETIC ACID, Beta-2-microglobulin, ... | Authors: | Tynan, F.E, Elhassen, D, Purcell, A.W, Burrows, J.M, Borg, N.A, Miles, J.J, Williamson, N.A, Green, K.J, Tellam, J, Kjer-Nielsen, L, McCluskey, J, Rossjohn, J, Burrows, S.R. | Deposit date: | 2005-09-05 | Release date: | 2005-11-29 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation J.Exp.Med., 202, 2005
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3BP7
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![BU of 3bp7 by Molmil](/molmil-images/mine/3bp7) | The high resolution crystal structure of HLA-B*2709 in complex with a Cathepsin A signal sequence peptide, pCatA | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | Authors: | Kumar, P, Vahedi-Faridi, A, Saenger, W, Uchanska-Ziegler, B, Ziegler, A. | Deposit date: | 2007-12-18 | Release date: | 2008-12-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens J.Biol.Chem., 284, 2009
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1JGU
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![BU of 1jgu by Molmil](/molmil-images/mine/1jgu) | STRUCTURAL BASIS FOR DISFAVORED ELIMINATION REACTION IN CATALYTIC ANTIBODY 1D4 | Descriptor: | (2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONE, Antibody Heavy Chain, Antibody Light Chain, ... | Authors: | Larsen, N.A, Heine, A, Crane, L, Cravatt, B.F, Lerner, R.A, Wilson, I.A. | Deposit date: | 2001-06-26 | Release date: | 2001-12-05 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for a disfavored elimination reaction in catalytic antibody 1D4. J.Mol.Biol., 314, 2001
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3BO8
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![BU of 3bo8 by Molmil](/molmil-images/mine/3bo8) | The High Resolution Crystal Structure of HLA-A1 Complexed with the MAGE-A1 Peptide | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | Authors: | Kumar, P, Vahedi-Faridi, A, Saenger, W, Ziegler, A, Uchanska-Ziegler, B. | Deposit date: | 2007-12-17 | Release date: | 2008-12-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity Protein Sci., 18, 2009
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8SBK
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![BU of 8sbk by Molmil](/molmil-images/mine/8sbk) | Structure of HLA-A*24:02 in complex with peptide, LYLPVRVLI (ATG2A). | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, LEU-TYR-LEU-PRO-VAL-ARG-VAL-LEU-ILE, ... | Authors: | Mallik, L, Young, M.C, Sgourakis, N.G. | Deposit date: | 2023-04-03 | Release date: | 2023-12-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion. Sci Immunol, 8, 2023
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3C5J
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![BU of 3c5j by Molmil](/molmil-images/mine/3c5j) | Crystal structure of HLA DR52c | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Elongation factor 1-alpha 2, HLA class II histocompatibility antigen, ... | Authors: | Dai, S, Kappler, J.W. | Deposit date: | 2008-01-31 | Release date: | 2008-08-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles. Proc.Natl.Acad.Sci.USA, 105, 2008
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3X13
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![BU of 3x13 by Molmil](/molmil-images/mine/3x13) | Crystal structure of HLA-B*0801.N80I | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-8 alpha chain, ... | Authors: | Vivian, J.P, Rossjohn, J. | Deposit date: | 2014-10-24 | Release date: | 2014-12-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The interaction of KIR3DL1*001 with HLA class I molecules is dependent upon molecular microarchitecture within the Bw4 epitope J.Immunol., 194, 2015
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5W38
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![BU of 5w38 by Molmil](/molmil-images/mine/5w38) | 1.80A resolution structure of human IgG3 Fc (N392K) | Descriptor: | CITRATE ANION, Immunoglobulin heavy constant gamma 3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Lovell, S, Mehzabeen, N, Battaile, K.P, Shah, I, Tolbert, T.J. | Deposit date: | 2017-06-07 | Release date: | 2017-10-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural characterization of the Man5 glycoform of human IgG3 Fc. Mol. Immunol., 92, 2017
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3FQT
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![BU of 3fqt by Molmil](/molmil-images/mine/3fqt) | |
1KCV
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![BU of 1kcv by Molmil](/molmil-images/mine/1kcv) | Crystal structure of antibody pc282 | Descriptor: | PC282 IMMUNOGLOBULIN | Authors: | Nair, D.T, Singh, K, Siddiqui, Z, Nayak, B.P, Rao, K.V, Salunke, D.M. | Deposit date: | 2001-11-11 | Release date: | 2002-05-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response. J.Immunol., 168, 2002
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1UM6
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![BU of 1um6 by Molmil](/molmil-images/mine/1um6) | catalytic antibody 21h3 | Descriptor: | antibody 21h3, H chain, L chain | Authors: | Beuscher IV, A.E, Reuter, J, Olson, A.J, Romesberg, F.E, Schultz, P.G, Wirsching, P, Janda, K.D, Lerner, R.A, Stevens, R.C. | Deposit date: | 2003-09-23 | Release date: | 2004-10-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Studies of an Efficient Catalytic Antibody Operating by Ping-Pong and Induced Fit Mechanisms To be Published
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1UVQ
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![BU of 1uvq by Molmil](/molmil-images/mine/1uvq) | Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, GLYCINE, ... | Authors: | Siebold, C, Hansen, B.E, Wyer, J.R, Harlos, K, Esnouf, R.E, Svejgaard, A, Bell, J.I, Strominger, J.L, Jones, E.Y, Fugger, L. | Deposit date: | 2004-01-22 | Release date: | 2004-02-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of Hla-Dq0602 that Protects Against Type 1 Diabetes and Confers Strong Susceptibility to Narcolepsy Proc.Natl.Acad.Sci.USA, 101, 2004
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5VUE
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![BU of 5vue by Molmil](/molmil-images/mine/5vue) | HLA-B*57:01 presenting LTVQVARVW | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-57 alpha chain, ... | Authors: | Pymm, P, Rossjohn, J, Vivian, J.P. | Deposit date: | 2017-05-19 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome. Nat Commun, 9, 2018
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2ZSV
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![BU of 2zsv by Molmil](/molmil-images/mine/2zsv) | Crystal structure of H-2Kb in complex with JHMV epitope S598 | Descriptor: | 8-mer peptide from spike glycoprotein, Beta-2-microglobulin, CYSTEINE, ... | Authors: | Theodossis, A, Dunstone, M.A, Rossjohn, J. | Deposit date: | 2008-09-18 | Release date: | 2008-11-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant. Plos Pathog., 4, 2008
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2Z9T
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![BU of 2z9t by Molmil](/molmil-images/mine/2z9t) | Crystal structure of the human beta-2 microglobulin mutant W60G | Descriptor: | Beta-2-microglobulin | Authors: | Ricagno, S, Bolognesi, M, Bellotti, V, Corazza, A, Rennella, E, Gural, D, Mimmi, M.C, Betto, E, Pucillo, C, Fogolari, F, Viglino, P, Raimondi, S, Giorgetti, S, Bolognesi, B, Merlini, G, Stoppini, M. | Deposit date: | 2007-09-26 | Release date: | 2008-04-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties J.Mol.Biol., 378, 2008
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1I7U
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![BU of 1i7u by Molmil](/molmil-images/mine/1i7u) | CRYSTAL STRUCTURE OF CLASS I MHC A2 IN COMPLEX WITH PEPTIDE P1049-6V | Descriptor: | 9 RESIDUE PEPTIDE, BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ... | Authors: | Busslep, J, Zhao, R, Loftus, D, Appella, E, Collins, E.J. | Deposit date: | 2001-03-10 | Release date: | 2001-10-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | T cell activity correlates with oligomeric peptide-major histocompatibility complex binding on T cell surface J.Biol.Chem., 276, 2001
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3L3D
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![BU of 3l3d by Molmil](/molmil-images/mine/3l3d) | Crystal structure of HLA-B*4402 in complex with the F3A mutant of a self-peptide derived from DPA*0201 | Descriptor: | ACETATE ION, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Theodossis, A, Ely, L.K, Rossjohn, J. | Deposit date: | 2009-12-16 | Release date: | 2010-03-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition Proc.Natl.Acad.Sci.USA, 107, 2010
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