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1R2Q
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BU of 1r2q by Molmil
Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution
Descriptor: GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Terzyan, S, Zhu, G, Li, G, Zhang, X.C.
Deposit date:2003-09-29
Release date:2003-12-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution.
Acta Crystallogr.,Sect.D, 60, 2004
1IOZ
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BU of 1ioz by Molmil
Crystal Structure of the C-HA-RAS Protein Prepared by the Cell-Free Synthesis
Descriptor: GUANOSINE-5'-DIPHOSPHATE, TRANSFORMING PROTEIN P21/H-RAS-1
Authors:Kigawa, T, Yamaguchi-Nunokawa, E, Kodama, K, Matsuda, T, Yabuki, T, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2001-04-18
Release date:2001-10-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selenomethionine incorporation into a protein by cell-free synthesis
J.STRUCT.FUNCT.GENOM., 2, 2001
1P2V
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BU of 1p2v by Molmil
H-RAS 166 in 60 % 1,6 hexanediol
Descriptor: HEXANE-1,6-DIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Buhrman, G.K, de Serrano, V, Mattos, C.
Deposit date:2003-04-16
Release date:2003-08-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Organic solvents order the dynamic switch II in Ras crystals
Structure, 11, 2003
1RVD
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BU of 1rvd by Molmil
H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP
Descriptor: 3-AMINOBENZOPHENONE-4-YL-AMINOHYDROXYPHOSPHINYLAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, TRANSFORMING PROTEIN P21/H-RAS-1
Authors:Ahmadian, M.R, Zor, T, Vogt, D, Kabsch, W, Selinger, Z, Wittinghofer, A, Scheffzek, K.
Deposit date:1999-05-03
Release date:1999-05-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Proc.Natl.Acad.Sci.USA, 96, 1999
4L8G
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BU of 4l8g by Molmil
Crystal Structure of K-Ras G12C, GDP-bound
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M.
Deposit date:2013-06-17
Release date:2013-11-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.521 Å)
Cite:K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
Nature, 503, 2013
5B2Z
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BU of 5b2z by Molmil
H-Ras WT in complex with GppNHp (state 2*) before structural transition by humidity control
Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
Authors:Kumasaka, T, Miyano, N, Baba, S, Matsumoto, S, Kataoka, T, Shima, F.
Deposit date:2016-02-07
Release date:2016-06-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Molecular Mechanism for Conformational Dynamics of Ras-GTP Elucidated from In-Situ Structural Transition in Crystal
Sci Rep, 6, 2016
5A0F
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BU of 5a0f by Molmil
Crystal structure of Yersinia Afp18-modified RhoA
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Jank, T, Schimpl, M, van Aalten, D.M.
Deposit date:2015-04-20
Release date:2015-07-22
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos.
Nat Commun, 6, 2015
521P
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BU of 521p by Molmil
THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, H-RAS P21 PROTEIN, MAGNESIUM ION
Authors:Schlichting, I, Krengel, U, Kabsch, W, Wittinghofer, A, Pai, E.F.
Deposit date:1991-06-06
Release date:1994-01-31
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
5B30
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BU of 5b30 by Molmil
H-Ras WT in complex with GppNHp (state 1) after structural transition by humidity control
Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
Authors:Kumasaka, T, Miyano, N, Baba, S, Matsumoto, S, Kataoka, T, Shima, F.
Deposit date:2016-02-08
Release date:2016-06-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular Mechanism for Conformational Dynamics of Ras-GTP Elucidated from In-Situ Structural Transition in Crystal
Sci Rep, 6, 2016
5C1T
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BU of 5c1t by Molmil
Crystal structure of the GTP-bound wild type EhRabX3 from Entamoeba histolytica
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Small GTPase EhRabX3
Authors:Srivastava, V.K, Chandra, M, Datta, S.
Deposit date:2015-06-15
Release date:2016-04-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Crystal Structure Analysis of Wild Type and Fast Hydrolyzing Mutant of EhRabX3, a Tandem Ras Superfamily GTPase from Entamoeba histolytica.
J.Mol.Biol., 428, 2016
5C4M
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BU of 5c4m by Molmil
RhoA GDP with novel switch II conformation
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA
Authors:Pellegrini, E, Bowler, M.W.
Deposit date:2015-06-18
Release date:2016-06-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:RhoA GDP with novel switch II conformation
To Be Published
5CIW
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BU of 5ciw by Molmil
Ran GDP Y39A mutant monoclinic crystal form
Descriptor: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Vetter, I.R, Brucker, S.
Deposit date:2015-07-13
Release date:2015-09-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy.
J.Biol.Chem., 290, 2015
5CIQ
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BU of 5ciq by Molmil
Ran GDP wild type tetragonal crystal form
Descriptor: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Vetter, I.R, Brucker, S.
Deposit date:2015-07-13
Release date:2015-09-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy.
J.Biol.Chem., 290, 2015
5CIT
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BU of 5cit by Molmil
Ran GDP wild type monoclinic crystal form
Descriptor: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Vetter, I.R, Brucker, S.
Deposit date:2015-07-13
Release date:2015-09-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy.
J.Biol.Chem., 290, 2015
5CJ2
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BU of 5cj2 by Molmil
Ran GDP Y39A mutant triclinic crystal form
Descriptor: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vetter, I.R, Brucker, S.
Deposit date:2015-07-13
Release date:2015-09-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy.
J.Biol.Chem., 290, 2015
5C1S
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BU of 5c1s by Molmil
Crystal structure of the GDP-bound fast hydrolyzing mutant (V71A/K73Q) of EhRabX3 from Entamoeba histolytica
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Small GTPase EhRabX3
Authors:Srivastava, V.K, Chandra, M, Datta, S.
Deposit date:2015-06-15
Release date:2016-04-27
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure Analysis of Wild Type and Fast Hydrolyzing Mutant of EhRabX3, a Tandem Ras Superfamily GTPase from Entamoeba histolytica.
J.Mol.Biol., 428, 2016
2L0X
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BU of 2l0x by Molmil
Solution structure of the 21 kDa GTPase RHEB bound to GDP
Descriptor: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Stoll, R, Heumann, R, Berghaus, C, Kock, G.
Deposit date:2010-07-19
Release date:2010-08-04
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.
J.Biol.Chem., 285, 2010
3KKQ
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BU of 3kkq by Molmil
Crystal structure of M-Ras P40D in complex with GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein M-Ras
Authors:Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T.
Deposit date:2009-11-06
Release date:2010-06-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural basis for conformational dynamics of GTP-bound Ras protein
J.Biol.Chem., 285, 2010
2RAP
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BU of 2rap by Molmil
THE SMALL G PROTEIN RAP2A IN COMPLEX WITH GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RAP2A
Authors:Cherfils, J, Menetrey, J, Lebras, G.
Deposit date:1998-05-06
Release date:1998-06-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.
EMBO J., 16, 1997
8PI0
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BU of 8pi0 by Molmil
NMR2 Structure of KRAS G12V (GMPPNP bound) in complex with 5-(1H-indol-2-l)piperazin-2-one
Descriptor: (5~{S})-5-(1~{H}-indol-2-yl)piperazin-2-one, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b
Authors:Buetikofer, M, Orts, J.
Deposit date:2023-06-20
Release date:2024-07-10
Last modified:2025-05-07
Method:SOLUTION NMR
Cite:NMR2-Based Drug Discovery Pipeline Presented on the Oncogenic Protein KRAS.
J.Am.Chem.Soc., 147, 2025
8PIY
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BU of 8piy by Molmil
NMR2 Structure of KRAS G12V (GMPPNP bound) in complex with (2E)-3-(1H-indol-2-yl)prop-2-enoic acid
Descriptor: (~{E})-3-(1~{H}-indol-3-yl)prop-2-enoic acid, RASK GTPase (Fragment)
Authors:Buetikofer, M, Orts, J.
Deposit date:2023-06-22
Release date:2024-07-10
Last modified:2025-05-07
Method:SOLUTION NMR
Cite:NMR2-Based Drug Discovery Pipeline Presented on the Oncogenic Protein KRAS.
J.Am.Chem.Soc., 147, 2025
3KKM
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BU of 3kkm by Molmil
Crystal structure of H-Ras T35S in complex with GppNHp
Descriptor: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T.
Deposit date:2009-11-06
Release date:2010-06-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for conformational dynamics of GTP-bound Ras protein
J.Biol.Chem., 285, 2010
3KKP
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BU of 3kkp by Molmil
Crystal structure of M-Ras P40D in complex with GppNHp
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein M-Ras
Authors:Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T.
Deposit date:2009-11-06
Release date:2010-06-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural basis for conformational dynamics of GTP-bound Ras protein
J.Biol.Chem., 285, 2010
2RGD
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BU of 2rgd by Molmil
Crystal structure of H-RasQ61L-GppNHp
Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
Authors:Buhrman, G, Wink, G, Mattos, C.
Deposit date:2007-10-03
Release date:2007-12-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf.
Structure, 15, 2007
1JAH
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BU of 1jah by Molmil
H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MAGNESIUM
Descriptor: C-HA-RAS, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
Authors:Schweins, T, Scheffzek, K, Assheuer, R, Wittinghofer, A.
Deposit date:1996-12-15
Release date:1997-07-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+.
J.Mol.Biol., 266, 1997

238895

數據於2025-07-16公開中

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