8T9A
| CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3 | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, Melanoma-associated antigen 3 | Authors: | Duda, D, Righetto, G, Li, Y, Loppnau, P, Seitova, A, Santhakumar, V, Halabelian, L, Yin, Y. | Deposit date: | 2023-06-23 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3 To Be Published
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8T99
| Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with Scyllo-L-1,4-[PP]2-(2,3)IP2, Mg, and Fluoride ion | Descriptor: | (1R,2S,3S,4R,5S,6S)-2,3-dihydroxy-5,6-bis(phosphonooxy)cyclohexane-1,4-diyl bis[trihydrogen (diphosphate)], CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T98
| Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with Scyllo-3-PP-(1,2,4,5)IP4, Mg, and Fluoride ion | Descriptor: | (1r,2R,3S,4r,5R,6S)-4-hydroxy-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T97
| Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ADP and scyllo-IP6 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, D-chiro inositol hexakisphosphate, Kinase, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T96
| Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ADP and scyllo-IP5 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinase, MAGNESIUM ION, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T95
| Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ADP and scyllo-(1,2,4,5)-IP4 | Descriptor: | (1S,3R,4R,6S)-1,3,4,6-TETRAPKISPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, Kinase, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T94
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8T93
| Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ADP and scyllo-L-(1,2,3,4)-IP4 | Descriptor: | (1R,2S,3S,4R,5S,6S)-5,6-dihydroxycyclohexane-1,2,3,4-tetrayl tetrakis[dihydrogen (phosphate)], ADENOSINE-5'-DIPHOSPHATE, Kinase, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T92
| Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ADP and scyllo-D-(1,2,3,4)-IP4 | Descriptor: | (1S,2R,3R,4S,5R,6R)-5,6-dihydroxycyclohexane-1,2,3,4-tetrayl tetrakis[dihydrogen (phosphate)], ADENOSINE-5'-DIPHOSPHATE, Kinase, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T91
| Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ADP and myo-IP6 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Kinase, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T90
| Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ADP and myo-(3OH)IP5 | Descriptor: | (1R,2R,3R,4S,5R,6R)-6-hydroxycyclohexane-1,2,3,4,5-pentayl pentakis[dihydrogen (phosphate)], ADENOSINE-5'-DIPHOSPHATE, Kinase, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T8Z
| Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ADP and myo-(1OH)IP5 | Descriptor: | (1S,2R,3S,4S,5S,6S)-6-hydroxycyclohexane-1,2,3,4,5-pentayl pentakis[dihydrogen (phosphate)], ADENOSINE-5'-DIPHOSPHATE, Kinase, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T8Y
| Crystal structure of Terrestrivirus inositol pyrophosphate kinase in complex with ADP and 1,4,5-InsP3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Kinase, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T8X
| Crystal structure of Terrestrivirus inositol pyrophosphate kinase in complex with AMP-PNP | Descriptor: | CADMIUM ION, Kinase, PHOSPHATE ION, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T8W
| Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CADMIUM ION, Kinase, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T8V
| Crystal structure of Terrestrivirus inositol pyrophosphate kinase in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinase, MAGNESIUM ION, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T8U
| Crystal structure of Terrestrivirus full-length Inositol pyrophosphate kinase in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinase, MAGNESIUM ION, ... | Authors: | Zong, G, Wang, H, Shears, S.B. | Deposit date: | 2023-06-23 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
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8T8S
| Sortilin-PGRN peptide complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Paragranulin peptide, ... | Authors: | Srivastava, D.B, Srivastava, A, Cherf, G.M, Low, L.Y, Kannan, G. | Deposit date: | 2023-06-23 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Structural studies of Sortilin-PGRN peptide complex To Be Published
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8T8R
| Sortilin-PGRN peptide complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Paragranulin peptide, Sortilin, ... | Authors: | Srivastava, D.B, Srivastava, A, Cherf, G.M, Low, L.Y, Kannan, G. | Deposit date: | 2023-06-23 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Structural studies of Sortilin-PGRN peptide complex To Be Published
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8T8Q
| Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors | Descriptor: | 1-[(3P)-3-(3-chloro-2-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Tang, Y, Nguyen, V, Wilbur, J.D. | Deposit date: | 2023-06-23 | Release date: | 2023-10-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors. J.Med.Chem., 66, 2023
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8T8P
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8T8O
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8T8N
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8T8M
| Quis-bound intermediate mGlu5 | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 5, Nb43 | Authors: | Krishna Kumar, K, Wang, H, Kobilka, B.K. | Deposit date: | 2023-06-22 | Release date: | 2023-10-11 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Stepwise activation of a metabotropic glutamate receptor. Nature, 629, 2024
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8T8L
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