5CGD
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![BU of 5cgd by Molmil](/molmil-images/mine/5cgd) | Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242) | Descriptor: | 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile, Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, OLEIC ACID | Authors: | Christopher, J.A, Aves, S.J, Bennett, K.A, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Okrasa, K, Serrano-Vega, M.J, Tehan, B.G, Wiggin, G.R, Congreve, M. | Deposit date: | 2015-07-09 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.603 Å) | Cite: | Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). J.Med.Chem., 58, 2015
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3AWU
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2X3V
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![BU of 2x3v by Molmil](/molmil-images/mine/2x3v) | Structure of The F-BAR Domain of Mouse Syndapin I | Descriptor: | PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1 | Authors: | Ma, Q, Rao, Y, Vahedi-Faridi, A, Saenger, W, Haucke, V. | Deposit date: | 2010-01-27 | Release date: | 2010-04-07 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Molecular Basis for SH3 Domain Regulation of F-Bar-Mediated Membrane Deformation. Proc.Natl.Acad.Sci.USA, 107, 2010
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4MT8
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7L1R
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![BU of 7l1r by Molmil](/molmil-images/mine/7l1r) | PS3 F1-ATPase Hydrolysis Dwell | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase gamma chain, ... | Authors: | Sobti, M, Ueno, H, Noji, H, Stewart, A.G. | Deposit date: | 2020-12-15 | Release date: | 2021-07-21 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | The six steps of the complete F 1 -ATPase rotary catalytic cycle. Nat Commun, 12, 2021
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5G6S
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![BU of 5g6s by Molmil](/molmil-images/mine/5g6s) | Imine reductase from Aspergillus oryzae in complex with NADP(H) and (R)-rasagiline | Descriptor: | IMINE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, RASAGILINE | Authors: | Man, H, Aleku, G, Turner, N.J, Grogan, G. | Deposit date: | 2016-06-23 | Release date: | 2017-05-31 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A reductive aminase from Aspergillus oryzae. Nat Chem, 9, 2017
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4MKT
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![BU of 4mkt by Molmil](/molmil-images/mine/4mkt) | Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue and 4-(4-benzylphenyl)thiazol-2-amine | Descriptor: | 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, 4-(4-benzylphenyl)-1,3-thiazol-2-amine, ACETIC ACID, ... | Authors: | Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z. | Deposit date: | 2013-09-05 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.618 Å) | Cite: | Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc.Natl.Acad.Sci.USA, 111, 2014
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3AWX
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1PDF
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![BU of 1pdf by Molmil](/molmil-images/mine/1pdf) | Fitting of gp11 crystal structure into 3D cryo-EM reconstruction of bacteriophage T4 baseplate-tail tube complex | Descriptor: | Baseplate structural protein Gp11 | Authors: | Kostyuchenko, V.A, Leiman, P.G, Chipman, P.R, Kanamaru, S, van Raaij, M.J, Arisaka, F, Mesyanzhinov, V.V, Rossmann, M.G. | Deposit date: | 2003-05-19 | Release date: | 2003-09-09 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (12 Å) | Cite: | Three-dimensional structure of bacteriophage T4 baseplate Nat.Struct.Biol., 10, 2003
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7QRV
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![BU of 7qrv by Molmil](/molmil-images/mine/7qrv) | Crystal structure of NHL domain of TRIM2 (full C-terminal) | Descriptor: | 1,2-ETHANEDIOL, Tripartite motif-containing protein 2 | Authors: | Chaikuad, A, Zhubi, R, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2022-01-12 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Comparative structural analyses of the NHL domains from the human E3 ligase TRIM-NHL family. Iucrj, 9, 2022
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4MU4
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![BU of 4mu4 by Molmil](/molmil-images/mine/4mu4) | The form B structure of an E21Q catalytic mutant of A. thaliana IGPD2 in complex with Mn2+ and its substrate, 2R3S-IGP, to 1.41 A resolution | Descriptor: | (2R,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate, 1,2-ETHANEDIOL, Imidazoleglycerol-phosphate dehydratase 2, ... | Authors: | Bisson, C, Britton, K.L, Sedelnikova, S.E, Baker, P.J, Rice, D.W. | Deposit date: | 2013-09-20 | Release date: | 2014-09-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination. Structure, 23, 2015
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4MUJ
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2WU2
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![BU of 2wu2 by Molmil](/molmil-images/mine/2wu2) | Crystal structure of the E. coli succinate:quinone oxidoreductase (SQR) SdhC His84Met mutant | Descriptor: | 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE, FE2/S2 (INORGANIC) CLUSTER, FE3-S4 CLUSTER, ... | Authors: | Ruprecht, J, Yankovskaya, V, Maklashina, E, Iwata, S, Cecchini, G. | Deposit date: | 2009-09-28 | Release date: | 2010-08-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of the E. Coli Succinate:Quinone Oxidoreductase (Sqr) Sdhc His84met Mutant To be Published
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5C7E
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![BU of 5c7e by Molmil](/molmil-images/mine/5c7e) | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal domain (1-209) in complex with Arabidopsis IAA10 peptide | Descriptor: | ASPR2 protein, Auxin-responsive protein IAA10, ZINC ION | Authors: | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | Deposit date: | 2015-06-24 | Release date: | 2015-08-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors. Sci Adv, 1, 2015
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5CGZ
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![BU of 5cgz by Molmil](/molmil-images/mine/5cgz) | Crystal structure of GalB, the 4-carboxy-2-hydroxymuconate hydratase, from Pseuodomonas putida KT2440 | Descriptor: | 4-oxalmesaconate hydratase, GLYCEROL, ZINC ION | Authors: | Mazurkewich, S, Brott, A.S, Kimber, M.S, Seah, S.Y.K. | Deposit date: | 2015-07-09 | Release date: | 2016-02-17 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | Structural and Kinetic Characterization of the 4-Carboxy-2-hydroxymuconate Hydratase from the Gallate and Protocatechuate 4,5-Cleavage Pathways of Pseudomonas putida KT2440. J.Biol.Chem., 291, 2016
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8UCS
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3AYV
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![BU of 3ayv by Molmil](/molmil-images/mine/3ayv) | TTHB071 protein from Thermus thermophilus HB8 soaking with ZnCl2 | Descriptor: | Putative uncharacterized protein TTHB071, ZINC ION | Authors: | Nakane, S, Wakamatsu, T, Fukui, K, Nakagawa, N, Masui, R, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2011-05-17 | Release date: | 2011-10-19 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | In vivo, in vitro, and x-ray crystallographic analyses suggest the involvement of an uncharacterized triose-phosphate isomerase (TIM) barrel protein in protection against oxidative stress J.Biol.Chem., 286, 2011
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8V3K
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![BU of 8v3k by Molmil](/molmil-images/mine/8v3k) | F95S-F198S epi-Isozizaene Synthase: complex with 3 Mg2+, inorganic pyrophosphate, and benzyl triethyl ammonium cation | Descriptor: | DIPHOSPHATE, Epi-isozizaene synthase, GLYCEROL, ... | Authors: | Christianson, D.W, Eaton, S.A. | Deposit date: | 2023-11-28 | Release date: | 2024-01-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of epi -Isozizaene Synthase into alpha-Bisabolol Synthase. Biochemistry, 63, 2024
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8UHE
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![BU of 8uhe by Molmil](/molmil-images/mine/8uhe) | Structure of the far-red light-absorbing allophycocyanin core expressed during FaRLiP | Descriptor: | ApcB2, ApcC, ApcD2, ... | Authors: | Gisriel, C.J, Bryant, D.A, Brudvig, G.W, Shen, G. | Deposit date: | 2023-10-09 | Release date: | 2024-01-03 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | Structure of the antenna complex expressed during far-red light photoacclimation in Synechococcus sp. PCC 7335. J.Biol.Chem., 300, 2023
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4MV7
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![BU of 4mv7 by Molmil](/molmil-images/mine/4mv7) | Crystal Structure of Biotin Carboxylase form Haemophilus influenzae in Complex with Phosphonoformate | Descriptor: | 1,2-ETHANEDIOL, Biotin carboxylase, PHOSPHONOFORMIC ACID | Authors: | Broussard, T.C, Pakhomova, S, Neau, D.B, Champion, T.S, Bonnot, R.J, Waldrop, G.L. | Deposit date: | 2013-09-23 | Release date: | 2015-01-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structural Analysis of Substrate, Reaction Intermediate, and Product Binding in Haemophilus influenzae Biotin Carboxylase. Biochemistry, 54, 2015
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4I5D
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![BU of 4i5d by Molmil](/molmil-images/mine/4i5d) | Crystal structure of Ralstonia sp. alcohol dehydrogenase in its apo form | Descriptor: | Alclohol dehydrogenase/short-chain dehydrogenase, SULFATE ION | Authors: | Jarasch, A, Lerchner, A, Meining, W, Schiefner, A, Skerra, A. | Deposit date: | 2012-11-28 | Release date: | 2013-06-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystallographic analysis and structure-guided engineering of NADPH-dependent Ralstonia sp. Alcohol dehydrogenase toward NADH cosubstrate specificity. Biotechnol.Bioeng., 110, 2013
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1PEV
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![BU of 1pev by Molmil](/molmil-images/mine/1pev) | Crystal Structure of the Actin Interacting Protein from Caenorhabditis Elegans | Descriptor: | Actin interacting protein 1 | Authors: | Vorobiev, S, Mohri, K, Fedorov, A.A, Ono, S, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2003-05-22 | Release date: | 2003-07-01 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments. J.Biol.Chem., 279, 2004
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5CHK
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![BU of 5chk by Molmil](/molmil-images/mine/5chk) | Crystal structure of avidin - HABA complex (hexagonal crystal form) | Descriptor: | 2-[2-(4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]benzoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Avidin | Authors: | Strzelczyk, P, Bujacz, A, Bujacz, G. | Deposit date: | 2015-07-10 | Release date: | 2016-03-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure and ligand affinity of avidin in the complex with 4-hydroxyazobenzene-2-carboxylic acid J.Mol.Struct., 1109, 2016
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8UFC
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7L5W
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![BU of 7l5w by Molmil](/molmil-images/mine/7l5w) | p97-R155H mutant dodecamer I | Descriptor: | Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L. | Deposit date: | 2020-12-23 | Release date: | 2021-08-04 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.34 Å) | Cite: | Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes. Int J Mol Sci, 22, 2021
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