9B6D
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![BU of 9b6d by Molmil](/molmil-images/mine/9b6d) | Cryo-EM structure of the mouse TRPM8 channel in the ligand-free desensitized state | Descriptor: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9B6I
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![BU of 9b6i by Molmil](/molmil-images/mine/9b6i) | Cryo-EM structure of the avian great tit TRPM8 channel in complex with the antagonist TC-I 2014 | Descriptor: | 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9B6E
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![BU of 9b6e by Molmil](/molmil-images/mine/9b6e) | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 | Descriptor: | 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9B6F
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![BU of 9b6f by Molmil](/molmil-images/mine/9b6f) | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMG2850 | Descriptor: | (8R)-8-[4-(trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-5,8-dihydro-1,7-naphthyridine-7(6H)-carboxamide, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9B6G
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![BU of 9b6g by Molmil](/molmil-images/mine/9b6g) | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMTB | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide, ... | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9B6K
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![BU of 9b6k by Molmil](/molmil-images/mine/9b6k) | Cryo-EM structure of the mouse TRPM8 channel in complex with Ca2+ in the absence of PI(4,5)P2 | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (4.13 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9B6H
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![BU of 9b6h by Molmil](/molmil-images/mine/9b6h) | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 and the cooling agonist C3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9B6J
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![BU of 9b6j by Molmil](/molmil-images/mine/9b6j) | Cryo-EM structure of the mouse TRPM8 channel in complex with PI(4,5)P2 and Ca2+ | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | Deposit date: | 2024-03-25 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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