4EKI
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![BU of 4eki by Molmil](/molmil-images/mine/4eki) | Crystal Structure of DOT1L in complex with EPZ004777 | Descriptor: | 7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... | Authors: | Jin, L. | Deposit date: | 2012-04-09 | Release date: | 2012-10-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. Chem.Biol.Drug Des., 80, 2012
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4EKG
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![BU of 4ekg by Molmil](/molmil-images/mine/4ekg) | Crystal Structure of DOT1L in Complex with EPZ003696 | Descriptor: | 5'-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(methyl)amino]-5'-deoxyadenosine, Histone-lysine N-methyltransferase, H3 lysine-79 specific | Authors: | Jin, L. | Deposit date: | 2012-04-09 | Release date: | 2012-10-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. Chem.Biol.Drug Des., 80, 2012
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4EK9
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![BU of 4ek9 by Molmil](/molmil-images/mine/4ek9) | Crystal structure of DOT1L in complex with EPZ000004 | Descriptor: | 5'-deoxy-5'-(dimethylamino)adenosine, GLYCEROL, Histone-lysine N-methyltransferase, ... | Authors: | Jin, L. | Deposit date: | 2012-04-09 | Release date: | 2012-10-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. Chem.Biol.Drug Des., 80, 2012
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