8CDG
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![BU of 8cdg by Molmil](/molmil-images/mine/8cdg) | Crystal structure of human IL-17A cytokine in complex with macrocycle | Descriptor: | (9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid, Interleukin-17A | Authors: | Schulze, M.-S. | Deposit date: | 2023-01-30 | Release date: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism. Chem Sci, 14, 2023
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